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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Blog of Signaling Pathways

Plasmodium falciparum formins are essential for invasion and sexual stage development

191 views | Feb 16 2024

"By elucidating the distinct roles of Plasmodium falciparum formins 1 and 2 (FRM1 and FRM2) in various stages of the malaria parasite's lifecycle and demonstrating the efficacy of the small molecule inhibitor SMIFH2 in blocking multiple stages of parasite development, this research presents promising avenues for targeted intervention and a deeper comprehension of malaria pathogenesis." [Read the Full Post]

Cholic Acid-Derived Gemini Amphiphile Can Eradicate Interkingdom Polymicrobial Biofilms and Wound Infections

137 views | Feb 16 2024

The bile acid-derived gemini amphiphile G21 exhibits broad-spectrum antimicrobial efficacy, disrupting microbial cell membranes and eradicating polymicrobial biofilms while curbing drug resistance, indicating its potential as a versatile agent for combatting chronic infections. [Read the Full Post]

[Mutational Signatures Analysis of Micropapillary Components and Exploration of ZNF469 Gene in Early-stage Lung Adenocarcinoma with Ground-glass Opacities]

139 views | Feb 16 2024

Your research illuminates the unique mutational signatures in micropapillary components of early-stage invasive lung adenocarcinomas, unveiling the potential of ZNF469 as a diagnostic and prognostic biomarker while hinting at tailored therapeutic approaches for improved patient outcomes. [Read the Full Post]

Development and Characterization of Thiolated Cyclodextrin-Based Nanoparticles for Topical Delivery of Minoxidil

167 views | Feb 16 2024

This study demonstrates the potential of thiolated β-CD-based nanoparticles loaded with Minoxidil as an effective and non-irritating drug delivery system for treating scalp diseases topically. [Read the Full Post]

Comparing the Reliability of the Glomerular Filtration Rate Estimated with 99m-Technetium Diethylene-Triamine-Pentaacetate versus the Effective Renal Plasma Flow Obtained with 99m-Technetium Ethylene Dicysteine: A Prospective Observational Study

144 views | Feb 16 2024

The study compared different methods of estimating glomerular filtration rate (GFR) in patients with varying renal function, concluding that in individuals with renal dysfunction, calculating GFR from effective renal plasma flow (ERPF) obtained via 99m-technetium ethylene dicysteine (99mTc-EC) was more accurate than other techniques, particularly in contrast to Gates' method using a gamma camera, which tended to overestimate GFR. [Read the Full Post]

Mitochondria-Targeted Lipid Nanoparticles Loaded with Rotenone as a New Approach for the Treatment of Oncological Diseases

125 views | Feb 15 2024

This research demonstrates that modifying liposomes to carry a mitochondrial poison selectively targets and diminishes the mitochondrial function of specific cancer cells, showcasing promising advancements in targeted anticancer therapy. [Read the Full Post]

ROCK Inhibitors as an Alternative Therapy for Corneal Grafting: A Systematic Review

920 views | Feb 15 2024

The review on ROCK inhibitors for corneal wound healing showcases their diverse therapeutic potential across various ocular conditions, offering promise as an effective alternative to human donor tissue for addressing the significant unmet medical need in corneal blindness. [Read the Full Post]

In silico design of novel bioactive molecules to treat breast cancer with chlorogenic acid derivatives: a computational and SAR approach

149 views | Feb 15 2024

The comprehensive computational analysis conducted on chlorogenic acid derivatives strongly indicates their potential as powerful inhibitors for the treatment of breast cancer, outperforming certain standard drugs in docking scores and demonstrating promising interactions and favorable ADME profiles. [Read the Full Post]

Multiplex Screening for Interacting Compounds in Paediatric Acute Myeloid Leukaemia

267 views | Feb 15 2024

The MuSICAL screening strategy efficiently identified a potentially effective triple combination therapy for paediatric AML using FDA-approved compounds, showcasing promising avenues for rapid clinical translation and therapeutic advancements. [Read the Full Post]

Proteomic and Phosphoproteomic Profiling Reveals the Oncogenic Role of Protein Kinase D Family Kinases in Cholangiocarcinoma

733 views | Feb 15 2024

The comprehensive analysis of protein and phosphorylation signatures in cholangiocarcinoma revealed the PRKD family's pivotal role, highlighting their potential as novel treatment targets validated by the inhibitory effects of 1-naphthyl PP1 on CCA cell proliferation, migration, and invasion. [Read the Full Post]

Exploration of a new class of monoamine oxidase B inhibitors by assembling benzyloxy pharmacophore on halogenated chalcones

128 views | Feb 14 2024

BB2 and BB4, derivatives of benzyloxy-derived halogenated chalcones, exhibit potent, selective, and reversible inhibition of MAO-B, marking them as promising drug candidates for treating neurodegenerative disorders like Parkinson's disease. [Read the Full Post]

Enhanced osteoblastic differentiation of parietal bone in a novel murine model of mucopolysaccharidosis type II

258 views | Feb 14 2024

The study's identification of a genomic modification in Ids-deficient mice underscores a possible connection between IDS deficiency and the augmented differentiation of calvarial bone, shedding light on the enlarged head circumference observed in individuals affected by MPS II. [Read the Full Post]

A Rare Case of Neurosyphilis with Calvaria Osteitis Presenting in Pregnancy

108 views | Feb 14 2024

Syphilitic osteitis and neuro, otic, or ocular syphilis during pregnancy, though rare and challenging to manage due to limited data, underscore the critical need for thorough screening, prompt recognition, and tailored treatment protocols to ensure optimal outcomes for both mother and fetus. [Read the Full Post]

Effects of Plant Regulators on the Seed Germination and Antioxidant Enzyme Activity of Cotton under Compound Salt Stress

127 views | Feb 14 2024

Soaking treatments employing compound sodium nitrophenolate (CSN) and 24-epibrassinolide (EBR) effectively enhance cotton germination under high-salt conditions by bolstering antioxidant enzyme activities, showcasing promising potential to improve cotton's salt tolerance. [Read the Full Post]

Protective Role of Ethanol Extract of Cibotium barometz (Cibotium Rhizome) against Dexamethasone-Induced Muscle Atrophy in C2C12 Myotubes

201 views | Feb 14 2024

This study demonstrates the potential of Cibotium Rhizome extract (ECR) in mitigating dexamethasone-induced muscle atrophy by modulating key proteins involved in muscle growth and atrophy pathways in C2C12 myotubes, offering a promising avenue for developing therapeutic agents against conditions like sarcopenia. [Read the Full Post]

Treatment of CHO cells with Taxol and reversine improves micronucleation and microcell-mediated chromosome transfer efficiency

155 views | Feb 13 2024

The synergistic combination of Taxol and reversine has revolutionized chromosomal transfer protocols, significantly enhancing efficiency across various cell lines and paving the way for accelerated advancements in genetic and regenerative medical research. [Read the Full Post]

Reduced Zn2+ promotes retinal ganglion cells survival and optic nerve regeneration after injury through inhibiting autophagy mediated by ROS/Nrf2

191 views | Feb 13 2024

Reduced mobile zinc (Zn2+) promotes retinal ganglion cell (RGC) survival and axonal regeneration post-optic nerve crush (ONC) injury by decreasing reactive oxygen species (ROS), activating Nrf2, and inhibiting autophagy, highlighting a potential therapeutic strategy via Zn2+ reduction using TPEN or conditional knockout of ZnT-3 in amacrine cells (ACs) for treating optic nerve damage. [Read the Full Post]

Hypoxia-activated glutamine antagonist prodrug combined with combretastatin A4 nanoparticles for tumor-selective metabolic blockade

255 views | Feb 13 2024

The development of HDON, a hypoxia-activated prodrug derived from DON, coupled with combretastatin A4 nanoparticles, demonstrates exceptional tumor selectivity and efficacy, achieving remarkable tumor suppression rates and cure rates in murine liver, colon, and breast cancer models. [Read the Full Post]

Natural Guanine Derivatives Exert PARP-Inhibitory and Cytoprotective Effects in a Model of Cardiomyocyte Damage under Oxidative Stress

153 views | Feb 13 2024

The compelling findings reveal the potential of guanine derivatives, particularly 7-methylguanine and 8-hydroxy-7-methylguanine, as potent inhibitors of PARP activation, offering promising avenues for therapeutic development in conditions associated with oxidative stress and inflammation. [Read the Full Post]

Effects of staged multiple phytohormones application on capillary-driven attached Chlorella sp. biofilm

287 views | Feb 13 2024

This study explores the synergistic effects of combining low concentrations of 6-benzylaminopurine and salicylic acid in microalgae cultivation for enhanced growth, antioxidative response, and efficient nutrient removal in wastewater treatment systems. [Read the Full Post]