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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

NLRP3

Splenic monocytes mediate inflammatory response and exacerbate myocardial ischemia/reperfusion injury in a mitochondrial cell-free DNA-TLR9-NLRP3-dependent fashion

76 views | Nov 26 2023

The study demonstrates that splenic NLRP3 inflammasome activation shortly after reperfusion onset, triggered by mitochondrial cell-free DNA and Toll-like receptor 9-dependent mechanisms, exacerbates myocardial ischemia/reperfusion injury. [Read the Full Post]

Dexamethasone and OLT1177 Cooperate in the Reduction of Melanoma Growth by Inhibiting STAT3 Functions

94 views | Oct 07 2023

The combination of OLT1177 and dexamethasone effectively reduces tumor growth by targeting both the nuclear and mitochondrial functions of STAT3, accompanied by downregulation of STAT3-dependent gene transcription and significant reductions in STAT3 phosphorylation. [Read the Full Post]

Delayed NLRP3 inflammasome inhibition ameliorates subacute stroke progression in mice

126 views | Jun 30 2023

The study found that inhibiting the NLRP3 inflammasome in the subacute phase of ischemic stroke reduced infarct size, improved functional outcomes, and mitigated local neuroinflammation, suggesting its potential as a pharmacological target for delayed treatment options. [Read the Full Post]

Non-Nucleoside Inhibitors Decrease Foot-and-Mouth Disease Virus Replication by Blocking the Viral 3Dpol

202 views | May 10 2023

The study used virtual screening and cell-based assays to identify potential inhibitors targeting the RNA-dependent RNA polymerase of Foot-and-mouth disease virus, and identified four compounds with antiviral activity. [Read the Full Post]

Membrane Attack Complex C5b-9 Promotes Renal Tubular Epithelial Cell Pyroptosis in Trichloroethylene-Sensitized Mice

178 views | Jun 06 2022

Feng Wang et al. found that complement C5b-9 played a central role in TCE-induced immune kidney damage, and the underlying mechanisms involved NLRP3-mediated pyroptosis. [Read the Full Post]

NLRP3-activated bone marrow dendritic cells play antileukemic roles via IL-1β/Th1/IFN-γ in acute myeloid leukemia

392 views | Jul 16 2021

Qinqin Liu et al. thought that NLRP3-activated BMDCs promoted the proliferation of IFN-γ-producing Th1 cells with antileukemic effects and might provide insight into the basis for leukemia immunotherapy in patients with AML. [Read the Full Post]