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PIKfyve

Dysregulation of the Progranulin-driven Autophagy-lysosomal Pathway Mediates Secretion of the Nuclear Protein TDP-43

233 views | Dec 27 2023

Dysregulation of the progranulin-driven autophagy-lysosomal pathway promotes the secretion of TDP-43, potentially fueling its cell-to-cell spread in neurodegenerative diseases like amyotrophic lateral sclerosis and frontotemporal lobar degeneration. [Read the Full Post]

Inhibition of PIKFYVE kinase interferes ESCRT pathway to suppress RNA virus replication

120 views | Oct 13 2023

The inhibition of PIKFYVE kinase by YM201636 disrupts the ESCRT pathway and endosomal transport, leading to the repression of replication for various RNA viruses, offering potential antiviral therapy against RNA virus infections. [Read the Full Post]

Rational Design and Synthesis of D-galactosyl Lysophospholipids as Selective Substrates and non-ATP-competitive Inhibitors of Phosphatidylinositol Phosphate Kinases

160 views | Dec 16 2022

Mengxia Sun et al. thought that D-galactose-based phosphoinositide mimetics could be developed into artificial substrates and new inhibitors of PIPKs. [Read the Full Post]

Apilimod enhances specific productivity in recombinant CHO cells through cell cycle arrest and mediation of autophagy

166 views | Dec 15 2022

Jiang-Tao Lu et al. found the potential of apilimod for development as a novel enhancer for the production of recombinant proteins in CHO cell engineering. [Read the Full Post]