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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Serine Protease

Natto extract inhibits infection caused by the Aujeszky

65 views | Dec 05 2023

The discovery that Fraction No. 10 from natto, a traditional Japanese fermented food, can functionally impair Aujeszky's disease virus (ADV) infection through serine protease inhibition, providing a potential avenue for developing natural antiviral treatments in the swine industry, holds significant promise for mitigating economic losses and promoting animal welfare. [Read the Full Post]

Assessing the venous system: Correlation of mean systemic filling pressure with the venous excess ultrasound grading system in cardiac surgery

138 views | Nov 20 2023

The study demonstrates a strong positive correlation between the venous excess ultrasound (VExUS) grading system and mean systemic filling pressure (Pmsf) in the early postoperative period after cardiac surgery, highlighting the critical role of systemic venous congestion in patient outcomes. [Read the Full Post]

Doxorubicin-induced cardiotoxicity is mediated by neutrophils through release of neutrophil elastase

151 views | Oct 02 2023

This study demonstrates that increased infiltration of neutrophils and the release of neutrophil elastase play a significant role in Doxorubicin-induced cardiotoxicity, highlighting potential therapeutic interventions for this condition. [Read the Full Post]

Thalidomide derivatives as nanomolar human neutrophil elastase inhibitors: Rational design, synthesis, antiproliferative activity and mechanism of action

0 views | Oct 01 2023

In this study, rationally designed human neutrophil elastase inhibitors derived from thalidomide demonstrated strong inhibitory activity, competitive mode of action, and promising antiproliferative effects against cancer cells, with compound 4f showing comparable HNE inhibition to sivelestat and inducing cell cycle arrest and apoptosis in T47D breast carcinoma cells. [Read the Full Post]

Pancreas Preservation with a Neutrophil Elastase Inhibitor, Alvelestat, Contributes to Improvement of Porcine Islet Isolation and Transplantation

129 views | Sep 28 2023

The study demonstrated that pancreatic preservation with alvelestat, a neutrophil elastase inhibitor, improved the yield and function of porcine islets, suggesting its potential as a novel clinical strategy for enhancing the outcome of islet transplantation. [Read the Full Post]

Thalidomide derivatives as nanomolar human neutrophil elastase inhibitors: Rational design, synthesis, antiproliferative activity and mechanism of action

196 views | Sep 27 2023

Through rational design, a series of thalidomide-derived compounds were synthesized, and compound 4f demonstrated strong inhibition of human neutrophil elastase (HNE), comparable to sivelestat, and exhibited enhanced antiproliferative activity against various cancer cell lines, inducing cell cycle arrest and apoptosis in T47D breast carcinoma cells. [Read the Full Post]

Identification of Embryonic Chicken Proteases Activating Newcastle Disease Virus and Their Roles in the Pathogenicity of Virus Used as In Ovo Vaccine

89 views | Jun 05 2023

The study identified five trypsin-like proteases that activate NDV in chicken embryos and found that the F protein with a 3B-FCS was crucial for the attenuation of NDV, providing a potential target for the rational design of safe in ovo ND vaccines. [Read the Full Post]

BC-1215 inhibits ATP-induced IL-1β secretion via the FBXL2-mediated ubiquitination and degradation of not only NLRP3, but also pro-IL-1β in LPS-primed THP-1 cells

154 views | May 10 2023

BC-1215, an inhibitor of FBXO3, suppresses ATP-induced IL-1β secretion in LPS-primed THP-1 cells via the FBXL2-mediated ubiquitination and degradation of NLRP3 and pro-IL-1β, making FBXO3 a potential therapeutic target for inflammatory diseases. [Read the Full Post]

Concentration dependence of active potassium transport in the human red blood cell in the presence of inhibitors

411 views | Mar 09 2023

The passage describes the inhibition of active potassium influx in human red blood cells by several compounds, including strophanthidin, ethacrynic acid, and MK-870, and suggests a model for the behavior of the transport system in the presence of these compounds and potassium ions. [Read the Full Post]

Metabolic characterization and GAPDH dependent regulation of ENaC in hPheo1 wild-type and SDHB knockdown cells

289 views | Mar 08 2023

The study investigates the expression and activity of ENaC and ASIC ion channels in hPheo1 WT and SDHB KD cells, which may provide important insights into understanding and treating SDHB-related disease. [Read the Full Post]