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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

PKD

Proteomic and Phosphoproteomic Profiling Reveals the Oncogenic Role of Protein Kinase D Family Kinases in Cholangiocarcinoma

735 views | Feb 15 2024

The comprehensive analysis of protein and phosphorylation signatures in cholangiocarcinoma revealed the PRKD family's pivotal role, highlighting their potential as novel treatment targets validated by the inhibitory effects of 1-naphthyl PP1 on CCA cell proliferation, migration, and invasion. [Read the Full Post]

Protein kinase D1 promotes the survival of random-pattern skin flaps in rats

278 views | May 28 2023

The study demonstrated that PKD1 improves skin flap survival by promoting angiogenesis, reducing oxidative stress, and inhibiting apoptosis and inflammation, suggesting it as a potential therapeutic target for flap failure treatment. [Read the Full Post]

A Protein Kinase D Inhibitor Suppresses AKT on T cells and Antagonizes Cancer Immunotherapy by Anti-PD-1

188 views | Oct 26 2022

Kazuhide Miyamoto et al. thought that PKD was fundamentally required for T-cell reactivation by anti-PD-1, therefore inhibition of PKD was not appropriate for combination therapy with anti-PD-1. [Read the Full Post]

Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation

456 views | Dec 01 2021

Diane Heiser et al. found thta PKD auto-phosphorylation could be triggered by a broad range of stimuli unrelated to NLRP3 inflammasome assembly. [Read the Full Post]

Protein Kinase D1, Reduced in Human Pancreatic Tumors, Increases Secretion of Small Extracellular Vesicles From Cancer Cells That Promote Metastasis to Lung in Mice

709 views | Dec 14 2020

Milena Armacki et al. found that human pancreatic ductal adenocarcinoma had reduced levels of PRKD1 compared with nontumor pancreatic tissues. [Read the Full Post]