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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Bcl-2

Isolinderalactone Induces Apoptosis, Autophagy, Cell Cycle Arrest and MAPK Activation through ROS-Mediated Signaling in Colorectal Cancer Cell Lines

447 views | Jan 23 2024

Isolinderalactone demonstrates significant potential as a therapeutic agent for colorectal cancer by inducing G2/M phase arrest, apoptosis, autophagy, and MAPK pathway activation via ROS-mediated signaling in human CRC cells. [Read the Full Post]

CYD0281, a Bcl-2 BH4 domain antagonist, inhibits tumor angiogenesis and breast cancer tumor growth

133 views | Jan 17 2024

CYD0281, a newly discovered Bcl-2-BH4 antagonist, demonstrates remarkable potential as an anti-angiogenic therapy for breast cancer by inducing a conformational shift in Bcl-2, converting it into a pro-apoptotic molecule and inhibiting tumor growth. [Read the Full Post]

Lactate Dehydrogenase Gene Family in Spirometra mansoni (Cestoda: Diphyllobothriidea)-Phylogenetic Patterns and Molecular Characteristics

233 views | Jan 16 2024

This study on Spirometra mansoni identified 19 novel LDH members, delineated their expression patterns across developmental stages, characterized their structural features, enzymatic properties, and inhibition, providing fundamental insights into the diverse roles of LDHs in this parasite and related taxa. [Read the Full Post]

Myo/Nog Cells: The Jekylls and Hydes of the Lens

180 views | Dec 26 2023

This comprehensive study unveils the versatile behavior of Myo/Nog cells from embryonic development to adulthood, elucidating their crucial roles in eye formation, lens structure, and potential therapeutic avenues for preventing fibrotic diseases in ocular tissues. [Read the Full Post]

MCL1 Inhibition Overcomes the Aggressiveness Features of Triple-Negative Breast Cancer MDA-MB-231 Cells

55 views | Dec 22 2023

Inhibiting MCL1 through A-1210477 in triple-negative breast cancer (TNBC) MDA-MB-231 cells induces anoikis, impedes focal adhesion-mediated survival signaling pathways, diminishes migratory and invasive capabilities, reverses epithelial-mesenchymal transition (EMT) features, and suppresses stemness markers, suggesting a critical role for MCL1 in regulating TNBC aggressiveness and metastatic potential. [Read the Full Post]

UMI-77 Modulates the Complement Cascade Pathway and Inhibits Inflammatory Factor Storm in Sepsis Based on TMT Proteomics and Inflammation Array Glass Chip

96 views | Dec 05 2023

UMI-77, administered at 7.0 mg/kg, significantly improves the survival rate of septic mice by suppressing inflammatory storm-related cytokines and modulating the complement cascade pathway, revealing its potential as a treatment for sepsis. [Read the Full Post]

Experimental and Theoretical Estimations of Atrazine's Adsorption in Mangosteen-Peel-Derived Nanoporous Carbons

176 views | Nov 06 2023

This study investigated the removal of atrazine using nanoporous carbons derived from mangosteen-peel chars, focusing on the role of nitrogen groups and surface chemistry, and elucidating the importance of micropores and mesopores in the adsorption process. [Read the Full Post]

Coordination-Driven Self-Assembly of Biomedicine to Enhance Photodynamic Therapy by Inhibiting Proteasome and Bcl-2

128 views | Oct 16 2023

BSC, a self-delivery biomedicine formed through the coordination-driven self-assembly of BTZ, Sab, and Ce6, combines proteasome and Bcl-2 inhibitions with photodynamic therapy, exhibiting superior efficacy in tumor treatment and controlled drug release in the acidic tumor microenvironment. [Read the Full Post]

Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells

194 views | Aug 30 2023

This study investigates the synergistic effects of combining BCL-2 family inhibitors, particularly BH3 mimetics, to eliminate senescent cells and overcome resistance within the population, potentially providing a more effective and less toxic approach to treating age-associated diseases. [Read the Full Post]

Design of rigid protein-protein interaction inhibitors enables targeting of undruggable Mcl-1

124 views | Aug 30 2023

This work demonstrates the successful design of highly rigid inhibitors that induce a deepening of the protein binding pocket, providing valuable insights for targeting protein-protein interactions (PPIs) and potentially enabling the development of therapies for hematological cancers. [Read the Full Post]