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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Secretase

In vitro antineoplastic effects of MK0752 in HPV-positive head and neck squamous cell carcinoma

262 views | Dec 19 2023

The study demonstrates the potential therapeutic efficacy of the gamma-secretase inhibitor MK0752 in head and neck squamous cell carcinoma, particularly inducing apoptosis in human-papillomavirus-positive tumors, suggesting its viability as a targeted treatment option pending further validation and mechanistic exploration. [Read the Full Post]

Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin

231 views | Oct 06 2023

The study confirms that GPX4 acts as an oncogene, inhibits ferroptosis in cancer cells, and its inhibition enhances the anticancer effect of cisplatin. [Read the Full Post]

Timed Notch Inhibition Drives Photoreceptor Fate Specification in Human Retinal Organoids

373 views | Jul 12 2023

In this study, the researchers demonstrated that timing the inhibition of the Notch signaling pathway in human retinal organoids can enhance and synchronize the differentiation of photoreceptor cells, potentially leading to an enriched population of early cone or rod photoreceptors for transplantation therapies in vision loss disorders. [Read the Full Post]

Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors

187 views | Jul 12 2023

The phase 3 clinical trial showed that nirogacestat, an oral γ-secretase inhibitor, significantly improved progression-free survival, objective response rates, and patient-reported outcomes while presenting common but mostly low-grade adverse events in adults with progressing desmoid tumors. [Read the Full Post]

Astragaloside IV Alleviates Brain Injury Induced by Hypoxia via the Calpain-1 Signaling Pathway

259 views | Jun 07 2023

AS-IV can inhibit hypoxia-induced oxidative stress and apoptosis in hippocampal neurons by downregulating the calpain-1/HIF-1α/caspase-3 pathway. [Read the Full Post]

Towards personalized treatment with clozapine

383 views | Mar 30 2023

This study found that clozapine was more effective when used as a first- or second-line treatment, and identified factors associated with response to clozapine treatment and side effects, which could aid in the development of personalized treatment approaches for individuals with treatment-resistant schizophrenia. [Read the Full Post]

Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture

364 views | Mar 30 2023

The study suggests that targeting the Hedgehog signaling pathway and cancer stem cells using inhibitors like AY9944 and GANT61 can improve the sensitivity of anti-cancer drug treatment in colorectal tumor patient-derived ALI organoids and may be a useful combinational therapeutic strategy against metastatic colorectal cancer. [Read the Full Post]

LY450139 Inhibited Ti-Particle-Induced Bone Dissolution via Suppressing Notch and NF-κB Signaling Pathways

282 views | Feb 27 2023

The study found that LY450139 has the potential to prevent the failure of joint implants by inhibiting the formation of osteoclasts, which break down bone, through the inhibition of the NF-κB and Notch signaling pathways. [Read the Full Post]

Notch signaling-induced cyclin d1 in diabetes ameliorating effects of the isolated polysaccharide from Rosa canina: In vitro and in vivo studies

365 views | Nov 30 2022

Soraya Sajadimajd et al. thought that upregulation of Notch signaling-induced cyclin d1 could be proposed as the underlying diabetes-reducing effects of the isolated polysaccharide derivative. [Read the Full Post]

Down-regulated NEDD4L facilitates tumor progression through activating Notch signaling in lung adenocarcinoma

318 views | Aug 25 2022

Liping Lin et al. demonstrated that down-regulated NEDD4L facilitated LUAD progression by activating Notch signaling, and NEDD4L might be a promising target to treat LUAD. [Read the Full Post]