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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

TEAD

PPARα activation promotes liver progenitor cell-mediated liver regeneration by suppressing YAP signaling in zebrafish

128 views | Jan 22 2024

Activation of PPARα and subsequent suppression of YAP signaling promote liver progenitor cell differentiation into hepatocytes, offering potential therapeutic insights for chronic liver disease treatment. [Read the Full Post]

Novel Allosteric Effectors Targeting Human Transcription Factor TEAD

225 views | Oct 15 2023

Chemical modifications of inhibitors targeting the palmitate-binding pocket in TEAD1-4 proteins have led to the discovery of allosteric inhibitors that enhance communication between TEAD4 and YAP1 domains, offering potential therapeutic strategies for solid tumors. [Read the Full Post]

Pharmacological blockade of TEAD-YAP reveals its therapeutic limitation in cancer cells

132 views | Sep 28 2023

Targeting TEAD autopalmitoylation in YAP-dependent cancers shows promise as a therapeutic approach, but the transient cell cycle inhibition and the activation of the VGLL3-mediated SOX4/PI3K/AKT signaling axis present limitations that can be overcome through combination therapy with TEAD and AKT inhibitors. [Read the Full Post]

β-catenin ameliorates myocardial infarction by preventing YAP-associated apoptosis

352 views | Aug 18 2023

The study demonstrated that upregulation of β-catenin in myocardial infarction (MI) reduces cardiac tissue damage and cardiomyocyte apoptosis, and this effect is mediated, at least in part, through the reactivation of Yes-Associated Protein (YAP). [Read the Full Post]

Activation of skeletal muscle FAPs by LPA requires the Hippo signaling via the FAK pathway

250 views | Aug 11 2023

Lysophosphatidic acid (LPA) activates fibro/adipogenic progenitors (FAPs) in skeletal muscle by signaling through LPA1, promoting FAK phosphorylation and subsequent activation of the Hippo pathway. [Read the Full Post]

Hypoxia-induced YAP activation and focal adhesion turnover to promote cell migration in mesenchymal TNBC cells

390 views | Mar 08 2023

The study suggests that hypoxia-induced YAP activation is positively associated with mesenchymal TNBC cell migration and may be a novel factor responsible for promoting the aggressive behavior of TNBC cells under hypoxic conditions. [Read the Full Post]

Inhibitory Effect of Hemiscorpius lepturus Scorpion Venom Fractions on Tachyzoites of Toxoplasma gondii

168 views | Sep 02 2022

Lida Khaleghi Rostamkolaie et al. found that the scorpion venom-purified fractions possessed anti-parasitic activity against the tachyzoite of T. gondii and could be used in parasite-controlling studies. [Read the Full Post]

CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis

285 views | Sep 01 2022

Yuegui Guo et al. identified HHEX as a positive modulator of YAP/TEAD to promote colorectal tumorigenesis, providing a new therapeutic strategy for targeting YAP/TEAD in CRC. [Read the Full Post]

Design, Synthesis, and Antitumor Activity of Erlotinib Derivatives

634 views | May 08 2022

Long-Fei Mao et al. suggested that compound 3d suppressed cancer cell proliferation through the EGFR-TK pathway. [Read the Full Post]

Combination of Ocimum sanctum extract and Levetiracetam ameliorates cognitive dysfunction and hippocampal architecture in rat model of Alzheimer's disease

769 views | Jan 03 2022

H S Nandini et al. provided evidence for use of OSE, LEV and OSE+LEV against AD and epilepsy associated with AD in Aβ induced AD animal model. [Read the Full Post]