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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

ERK

Chaetocin-mediated SUV39H1 inhibition targets stemness and oncogenic networks of diffuse midline gliomas and synergizes with ONC201

473 views | Jan 22 2024

Targeting the SUV39H1-H3K9me3 pathway in DIPG cells with chaetocin, and combining it with a DRD2 antagonist like ONC201, presents a promising strategy for effective treatment by exploiting vulnerabilities and overcoming resistance mechanisms. [Read the Full Post]

Outcomes and Safety of Suprapubic vs Urethral Catheterization Following Pelvic Fascia Sparing Robotic Prostatectomy

173 views | Jan 10 2024

Suprapubic catheters post Pelvic Fascia Sparing Robotic-Assisted Radical Prostatectomy (PFS-RARP) exhibit a notable advantage over urethral catheters by enabling earlier continence recovery and higher continence rates at catheter removal, potentially enhancing overall patient satisfaction without compromising quality of life. [Read the Full Post]

Inhibition of DNA methylation attenuates lung ischemia-reperfusion injury after lung transplantation

220 views | Dec 11 2023

"Inhibition of DNA methylation, particularly through azathioprine treatment, attenuates lung ischemia-reperfusion injury by suppressing inflammation, oxidative stress, and endothelial dysfunction, highlighting its therapeutic potential for improving outcomes in lung transplantation." [Read the Full Post]

Targeting GSTP1 as Therapeutic Strategy against Lung Adenocarcinoma Stemness and Resistance to Tyrosine Kinase Inhibitors

326 views | Nov 07 2023

The study reveals that upregulation of Glutathione S-transferase pi (GSTP1) in lung adenocarcinoma (LUAD) supports cancer stem cells, tumor self-renewal, metastasis, and resistance to targeted therapies, making it a promising therapeutic target for long-term control of LUAD. [Read the Full Post]

Comprehensive Analysis of the Expression, Prognostic Value, and Immune Infiltration Activities of GABRD in Colon Adenocarcinoma

213 views | Nov 03 2023

GABRD expression in colon adenocarcinoma is significantly elevated and correlated with advanced clinical stage, poor prognosis, immune cell infiltration patterns, and potential drug resistance. [Read the Full Post]

ERK inhibitor ASN007 effectively overcomes acquired resistance to EGFR inhibitor in non-small cell lung cancer

199 views | Sep 27 2023

The study demonstrates that targeting the ERK signaling pathway with the selective inhibitor ASN007 in combination with EGFR TKIs holds promise for overcoming acquired resistance and inhibiting tumor growth in EGFR-mutated non-small cell lung cancer (NSCLC) patients. [Read the Full Post]

Evaluation of KRASG12C inhibitor responses in novel murine KRASG12C lung cancer cell line models

444 views | Aug 30 2023

The generation of three novel murine KRASG12C-driven lung cancer cell lines provides valuable models for studying and improving therapeutic combination strategies with KRASG12C inhibitors. [Read the Full Post]

Results of an open-label phase 1b study of the ERK inhibitor MK-8353 plus the MEK inhibitor selumetinib in patients with advanced or metastatic solid tumors

166 views | Aug 21 2023

The combination of MK-8353 and selumetinib at 50/25 mg and 100/50 mg doses demonstrated acceptable safety and tolerability in patients with advanced solid tumors, while the 150/75 mg dose level was found to be intolerable with no observed objective responses. [Read the Full Post]

Caveolae-associated protein 3 promotes adipogenic differentiation of porcine preadipocytes by promoting extracellular signal-regulated kinase phosphorylation

161 views | Aug 10 2023

The study demonstrated that CAVIN3 promotes adipogenic differentiation of porcine preadipocytes by enhancing ERK phosphorylation, providing insights into the molecular mechanism of porcine fat deposition. [Read the Full Post]

Apoptotic cell death in disease-Current understanding of the NCCD 2023

553 views | Jul 09 2023

The Nomenclature Committee on Cell Death (NCCD) critically summarizes the extensive pre-clinical literature linking the core apoptotic apparatus to organismal homeostasis in various disease contexts, highlighting its role in both disease etiology and potential therapeutic interventions. [Read the Full Post]