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Inhibition of thioredoxin-1 enhances the toxicity of glycolysis inhibitor 2-deoxyglucose by downregulating SLC1A5 expression in colorectal cancer cells

212 views | Jan 17 2024

The study reveals that Trx-1 mediates resistance to 2-deoxyglucose in colorectal cancer cells by upregulating SLC1A5, suggesting that targeting Trx-1 or SLC1A5 alongside glycolysis inhibition could offer a promising strategy for improving treatment efficacy. [Read the Full Post]