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Autophagy
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Cell Cycle
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TGF-beta/Smad
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DNA Damage/DNA Repair
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Stem Cells & Wnt
- GSK-3
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- PKA
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Hippo
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Ubiquitin
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Neuronal Signaling
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NF-κB
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GPCR & G Protein
- Ras
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- PAFR
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- cAMP
- CXCR
- PKD
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- PKG
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- Imidazoline Receptor
- Bombesin Receptor
- RGS
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- Sigma Receptor
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- PAR
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- NPY receptor
- Parathyroid Hormone Receptor
- DOCK
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- GPCR19
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- GRK
- Leukotriene
- FPR
- Prostaglandin Receptor
Endocrinology & Hormones
- Adrenergic Receptor
- 5-alpha Reductase
- Estrogen/progestogen Receptor
- Androgen Receptor
- RAAS
- Opioid Receptor
- Aromatase
- GPR
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- SSTR
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- THR
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Transmembrane Transporters
- CD markers
- Calcium Channel
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- ATPase
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- GluR
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- CFTR
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- SGLT
- GLUT
- GlyT
- NMDAR
- OCT
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- Amino acid transporter
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- OAT
- NKCC
- BCRP
- NCX
- OATP
- TRP Channel
- VRAC
- Aquaporin
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- VDAC
- MTP
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Metabolism
- PPAR
- P450 (e.g. CYP17)
- HSP (HSP90)
- PDE
- Hydroxylase
- Factor Xa
- DHFR
- Aminopeptidase
- Dehydrogenase
- Procollagen C Proteinase
- Phospholipase (e.g. PLA)
- DPP
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- Phosphorylase
- Liver X Receptor
- FAAH
- Acyltransferase
- Retinoid Receptor
- Thioredoxin
- FXR
- Transferase
- Serine/threonin kinase
- CETP
- IDO/TDO
- phosphatase
- GLUT
- HMG-CoA Reductase
- Vitamin
- PKM
- Lipoxygenase
- FOX
- Lipase
- Fatty Acid Synthase
- LDL
- NAMPT
- Casein Kinase
- Decarboxylase
- Adenosine Deaminase
- Aldose Reductase
- CPSase
- Leukotriene
- Adenosine Kinase
- OXPHOS
- Glutathione
- Acetyl-CoA carboxylase
- Mitochondrial Metabolism
- Peroxidases
- SHIP
- PCSK9
- PGDS
- Mitochondrial pyruvate carrier
- PREP
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- Neprilysin
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- FTO
- AdipoR
- PAD
- SREBP
- SCD
- CPT
- AP-1
- LDH
- Carbohydrate Metabolism
- CAR
- PAI-1
- γGCS
- SSTR
- ATP-citrate lyase
- FAO
- FTase
- SOD
- 3-MST
- GTPCH
- SGK
- GOT
- Serine hydrolase
- Epoxide Hydrolase
- glucocerebrosidase
- FABP
- Catalase
- THR
- ACSS2
- ROR
- Glucosylceramide Synthase
- ACE
- Thioredoxin Reductase
- PDHK
- PARG
- Xanthine Oxidase
- Mannosidase
- PGC-1α
Proteases
- HDAC
- Proteasome
- Caspase
- Aminopeptidase
- HCV Protease
- DPP
- HIV Protease
- MMP
- Thrombin
- Acyltransferase
- MALT
- Glutaminase
- Tyrosinase
- Serine Protease
- Cysteine Protease
- Cathepsin B
- PGDS
- Neprilysin
- SGK
- PREP
- GOT
- 3C-Like Protease
- PAD
- PCSK9
- Secretase
Microbiology
- HCV Protease
- Integrase
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- HIV Protease
- Anti-infection
- Influenza Virus
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- SARS-CoV
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- Parasite
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- Antiviral
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- 3C-Like Protease
- Antibiotics
- Enterovirus
- COVID-19
Others
- ADC Cytotoxin
- ADC Linker
- Drug-Linker Conjugates for ADC
- Antineoplastic and Immunosuppressive Antibiotics
- Selection Antibiotics for Transfected Cell
- Antibiotics for Mammalian Cell Culture
- Antibiotics for Plant Cell Culture
- Hydrotropic Agents
- Dyes
- PROTAC
- PROTAC Linker
- E3 ligase Ligand
- Target Protein Ligand
- Others
- Antibody-Drug Conjugate

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The Functional Role and Regulatory Mechanism of FTO m6A RNA Demethylase in Human Uterine Leiomyosarcoma

344 views | Oct 08 2023

In summary, the study highlights the aberrant upregulation of FTO m6A RNA demethylase in uterine leiomyosarcoma tissues and demonstrates that inhibiting FTO with Dac51 can significantly decrease uLMS cell proliferation, modulate key pathways, and potentially offer a novel therapeutic strategy for this aggressive uterine cancer. [Read the Full Post]

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The upregulation of the m6A mRNA demethylase FTO in radioresistant nasopharyngeal carcinoma (NPC) promotes radiotherapy resistance by inhibiting radiation-induced ferroptosis, suggesting FTO as a potential therapeutic target and prognostic biomarker for NPC. [Read the Full Post]