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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

COX

Protective Role of Ethanol Extract of Cibotium barometz (Cibotium Rhizome) against Dexamethasone-Induced Muscle Atrophy in C2C12 Myotubes

202 views | Feb 14 2024

This study demonstrates the potential of Cibotium Rhizome extract (ECR) in mitigating dexamethasone-induced muscle atrophy by modulating key proteins involved in muscle growth and atrophy pathways in C2C12 myotubes, offering a promising avenue for developing therapeutic agents against conditions like sarcopenia. [Read the Full Post]

A Randomized Controlled Trial of a Novel Formulation of Ketorolac Tromethamine for Continuous Infusion (NTM-001) in Healthy Volunteers

170 views | Feb 01 2024

The study's findings indicate that NTM-001, administered as a 12.5 mg IV bolus followed by continuous infusion, aligns closely with predicted pharmacokinetic parameters, demonstrating potential as a safe and effective nonopioid alternative for acute postoperative pain control. [Read the Full Post]

The protective effects of NE 52-QQ57 against interleukin-33-induced inflammatory response in activated synovial mast cells

595 views | Oct 09 2023

The study suggests that inhibiting GPR4 signaling with the antagonist NE 52-QQ57 may have therapeutic benefits in rheumatoid arthritis by reducing inflammatory responses and oxidative stress in synovial mast cells. [Read the Full Post]

Association of reported NSAID adverse drug reactions with opioid prescribing following total joint arthroplasty

398 views | Apr 14 2023

This retrospective cohort study found that reported adverse drug reactions to nonsteroidal anti-inflammatory drugs were associated with an increased risk of prolonged receipt of opioids following total joint arthroplasty. [Read the Full Post]

Mechanisms of paeoniaceae action as an antidepressant

243 views | Mar 22 2023

Paeoniflorin (PF) has been shown to have multiple mechanisms through which it exerts its antidepressant effects, including increasing the levels of monoamine neurotransmitters, inhibiting the HPA axis, promoting neuroprotection, enhancing neurogenesis in the hippocampus, and elevating levels of BDNF. [Read the Full Post]

Electrochemically assisted production of biogenic palladium nanoparticles for the catalytic removal of micropollutants in wastewater treatment plants effluent

171 views | Mar 11 2023

This work demonstrates the potential of biogenic palladium nanoparticles to remove persistent micropollutants from wastewater, with the size of the nanoparticles affecting their catalytic activity. [Read the Full Post]

Electrospun nanofibers using β-cyclodextrin grafted chitosan macromolecules loaded with indomethacin as an innovative drug delivery system

170 views | Mar 06 2023

The study developed a β-CD-g-CS nanofiber-based drug delivery system with sustained release of indomethacin and favorable physicomechanical properties and biocompatibility for use in orthopedic applications. [Read the Full Post]

Solvent-Mediated Tunable Regiodivergent C6- and N1-Alkylations of 2,3-Disubstituted Indoles with p-Quinone Methides

214 views | Mar 06 2023

A new method for regioselective alkylations of 2,3-disubstituted indoles with para-quinone methides using indium catalysts and solvents has been developed and can be selectively adjusted, scaled up, and applied to the late-stage functionalization of indomethacin with support from experimental and density functional theory studies. [Read the Full Post]

Current therapeutic modalities and chemopreventive role of natural products in liver cancer: Progress and promise

910 views | Feb 19 2023

Liver cancer treatment options depend on the progression stage of the disease and may include surgery, ablation and radiotherapy, first-line drugs and immunotherapy, and second-line chemotherapeutic drugs, while natural compounds like resveratrol, curcumin and diallyl sulfide are emerging as promising anticancer agents to manage liver cancer. [Read the Full Post]

Efficacy of Kampo medicine Kakkonto as acute medication to treat tension-type headache among musculoskeletal pain patients using regular analgesics

191 views | Feb 13 2023

Kakkonto showed efficacy as an acute medication for Tension-Type Headache with comorbidities, as it improved the pain score without any side effects in a small study of 10 patients with various painful comorbidities who had taken other analgesics. [Read the Full Post]