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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Dyes

Immunotactoid hepatopathy: A novel entity with histologically proven recurrence post liver transplantation

134 views | Feb 12 2024

This case of hepatic immunotactoid deposition following liver transplantation, managed with a Daratumumab-based regimen targeting underlying plasma-cell dyscrasia, exhibited encouraging outcomes in reducing serum paraproteins, resolving ascites, and improving kidney function without inducing rejection, showing promise for treating this rare complication. [Read the Full Post]

Detection of Reverse Transcriptase LAMP-Amplified Nucleic Acid from Oropharyngeal Viral Swab Samples Using Biotinylated DNA Probes through a Lateral Flow Assay

111 views | Feb 06 2024

This study presents a rapid, sensitive, and specific nucleic acid testing-point of care technique using crude throat swab samples, RT-LAMP-LFA readouts with biotinylated DNA probes, and digital semi-quantification, showcasing its potential as a versatile biosensor platform for efficient pathogen detection without the need for extensive sample processing. [Read the Full Post]

Local perfusion of capillaries reveals disrupted beta-amyloid homeostasis at the blood-brain barrier in Tg2576 murine Alzheimer's model

148 views | Feb 04 2024

This study reveals disrupted tight junction integrity, impaired transporter functionality, and decreased Aβ-receptor binding at the blood-brain barrier in Alzheimer's disease, prompting potential therapeutic strategies targeting these specific alterations. [Read the Full Post]

Adelmidrol ameliorates liver ischemia-reperfusion injury through activating Nrf2 signaling pathway

152 views | Feb 04 2024

Adelmidrol demonstrates promise in ameliorating liver ischemia/reperfusion injury by activating the Nrf2 signaling pathway, as evidenced by its reduction of inflammatory response, oxidative stress, and apoptosis in both mouse liver I/R injury models and AML12 cell hypoxia-reoxygenation experiments. [Read the Full Post]

Overcoming multi drug resistance mediated by ABC transporters by a novel acetogenin- annonacin from Annona muricata L

154 views | Feb 03 2024

The study's findings suggest that annonacin from Annona muricata has the potential to counteract drug resistance in colorectal cancer cells by inhibiting P-glycoprotein-mediated drug efflux, highlighting a promising avenue for future therapeutic developments. [Read the Full Post]

Highly Potent Peptide Therapeutics To Prevent Protein Aggregation in Huntington's Disease

116 views | Feb 03 2024

Peptide-based therapies exhibiting inhibition of mHtt fibril formation present a promising avenue for halting the progression of Huntington's disease by targeting the misfolded proteins associated with the condition. [Read the Full Post]

Role of MAPKs in TGF-β1-induced maturation and mineralization in human osteoblast-like cells

109 views | Feb 01 2024

"TGF-β1 induces mineralization in human osteoblast-like MG63 cells primarily through the activation of JNK within the MAPK signaling pathway." [Read the Full Post]

The Combination of Methioninase and Ethionine Exploits Methionine Addiction to Selectively Eradicate Osteosarcoma Cells and Not Normal Cells and Synergistically Down-regulates the Expression of C-MYC

130 views | Jan 13 2024

The study demonstrates the synergistic potential of combining recombinant methioninase (rMETase) and ethionine to selectively eradicate osteosarcoma cells while down-regulating c-MYC expression, highlighting a promising avenue for future clinical strategies against this form of cancer. [Read the Full Post]

Arum palaestinum delays hepatocellular carcinoma proliferation through the PI3K-AKT-mTOR signaling pathway and exhibits anticoagulant effects with antimicrobial properties

114 views | Oct 18 2023

The study revealed that the aqueous extract of Arum palaestinum Boiss (AP) flowers exhibited potent antimicrobial activity, anticoagulant properties, and potential as an anticancer agent by impacting cell cycle, HCC biomarkers, and the PI3K-AKT-mTOR signaling pathway. [Read the Full Post]

Charting the Chemical Reaction Space around a Multicomponent Combination: Controlled Access to a Diverse Set of Biologically Relevant Scaffolds

94 views | Jun 28 2023

Researchers have developed general protocols to selectively access desired chemotypes by combining carbonyls, amines, and isocyanoacetates, leading to the synthesis of unsaturated imidazolone scaffolds with the chromophore of the green fluorescent protein and the core structure of the natural product coelenterazine, as well as unprecedented reactivity at the C-2 position to obtain diverse derivatives featuring natural products, kinase inhibitors, and fluorescent probes. [Read the Full Post]