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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Factor Xa

Trends in the Use of Oral Anticoagulants for Adults With Venous Thromboembolism in the US, 2010-2020

126 views | Apr 13 2023

This retrospective cohort study using data from two US health insurance databases evaluated prescribing patterns of oral anticoagulants for patients with venous thromboembolism and identified clinical events that preceded treatment changes, highlighting the importance of identifying reasons for treatment modification for valid evidence on drug safety and effectiveness. [Read the Full Post]

DOAC compared with warfarin for VTE in patients with obesity: a retrospective cohort study conducted through the VENUS network

123 views | Feb 27 2023

The study found that DOACs were not inferior to warfarin in terms of VTE recurrence in obese patients and were associated with a lower major bleeding rate. [Read the Full Post]

Cost-effectiveness of targeted screening for non-valvular atrial fibrillation in the United Kingdom in older patients using digital approaches

180 views | Feb 27 2023

Screening for non-valvular atrial fibrillation in patients aged 75 or older in the UK is cost-effective and potentially cost-saving, with handheld digital devices such as Zenicor, pulse palpation, and KardiaMobile, and targeted screening predictive algorithms found to be the dominant options compared to no screening. [Read the Full Post]

Sample stability and heparin interference in ionized calcium and ionized magnesium measurements in horses using the Stat Profile Prime Plus co-oximetry electrolyte analyzer

284 views | Feb 17 2023

Stored samples at 4°C can be used to determine iCa and iMg concentrations up to 7 days after collection in horses, but heparin interference should be considered when using homemade heparin syringes and other metabolites are stable for only 8 hours. [Read the Full Post]

Clinical evaluation of laboratory methods to monitor exposure of rivaroxaban at trough and peak in patients with atrial fibrillation

565 views | Mar 15 2019

Al-Aieshy F et al. found that the POC assay for PT-INR could be useful to indicate high exposure to rivaroxaban in emergency situations although further validation is required. [Read the Full Post]

A novel, rapid method to compare the therapeutic windows of oral anticoagulants using the Hill coefficient

0 views | Aug 27 2018

Chang JB et al. showed a significant variation among the Hill coefficients, suggesting a similar variation in therapeutic windows among anticoagulants in our assay. [Read the Full Post]