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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Hydrotropic Agents

Pluronic F-127 Enhances the Antifungal Activity of Fluconazole against Resistant Candida Strains

138 views | Feb 02 2024

The study investigates how Pluronic F-127 (PLX) formulations loaded with fluconazole (FLU) potentially increase susceptibility in drug-resistant Candida strains, revealing a significant inhibitory effect on yeast growth, particularly at concentrations of 5.0% and 10.0% w/v of PLX, while detecting upregulation of CDR1/CDR2 genes, indicative of drug efflux as the primary resistance mechanism. [Read the Full Post]

Subchronic toxicity study of ferric oxide nanoparticles through intragastric administration: A 94-d, repeated dose study in Sprague Dawley rats

101 views | May 12 2023

The study found that Fe2O3 NPs administered through gavage to SD rats for 94 days did not show significant toxicity or adverse effects up to a dose of 500 mg/kg, followed by recovery after Fe2O3 NPs withdrawal for 30 days. [Read the Full Post]

Incorporating valsartan in sesame oil enriched self-nanoemulsifying system-loaded liquisolid tablets to improve its bioavailability

117 views | May 12 2023

This study developed liquisolid tablets containing a self-nanoemulsifying drug delivery system to improve the solubility and dissolution rate of Valsartan, resulting in increased bioavailability compared to the marketed product. [Read the Full Post]

Preferential Solvation Study of Rosuvastatin in the {PEG400 (1) + Water (2)} Cosolvent Mixture and GastroPlus Software-Based In Vivo Predictions

91 views | May 12 2023

The study investigates the solubility and preferential solvation of rosuvastatin in PEG400 + water binary mixtures and predicts that the RST-loaded mixture can enhance the drug's oral absorption and be a promising strategy to control systemic dyslipidemia. [Read the Full Post]

Optimization of the Solvent and In Vivo Administration Route of Auranofin in a Syngeneic Non-Small Cell Lung Cancer and Glioblastoma Mouse Model

110 views | May 12 2023

The study provides important information on the optimal administration route and solvent of auranofin in two syngeneic cancer mouse models, which could contribute to its further development as a potential cancer therapy. [Read the Full Post]

Hematological parameters, antioxidant status, and gene expression of γ-INF and IL-1β in vaccinated lambs fed different type of lipids

90 views | May 11 2023

The study suggests that flaxseed oil had more beneficial effects on the immune response than other vegetable oils in vaccinated lambs. [Read the Full Post]

Oil-free eye drops containing Cyclosporine A/cyclodextrin/PVA supramolecular complex as a treatment modality for dry eye disease

255 views | Oct 06 2022

Pinal Chaudhari et al. demonstrated the potential of the supramolecular complex as an alternative to the oil-based formulation of eye drops for drugs that showed low solubility and poor corneal permeation. [Read the Full Post]

Stability of Captisol-enabled versus propylene glycol-based melphalan at room temperature and after refrigeration

273 views | Jun 03 2022

Jitesh D Kawedia et al. found that CE-melphalan at 2 mg/mL has 24-hour stability at RT and can be used for extended infusion times or may be compounded ahead of time. Reconstituted CE-melphalan vials are stable for 48 hours at both RT and 4 °C. [Read the Full Post]

Three Birds, One Excipient: Development of an Improved pH, Isotonic, and Buffered Ketamine Formulation for Subcutaneous Injection

366 views | Jun 03 2022

Jason Wallach et al. found that this strategy has the potential to be readily adapted to other amine-based APIs. [Read the Full Post]

Physicochemical Characterization, Molecular Docking, and In Vitro Dissolution of Glimepiride-Captisol Inclusion Complexes

401 views | Jun 01 2022

Arpita Pal et al. found that complexation with Captisol enhanced the water solubility of glimepiride. [Read the Full Post]