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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Proteasome

PR-957 retards rheumatoid arthritis progression and inflammation by inhibiting LMP7-mediated CD4+ T cell imbalance

228 views | Jan 21 2024

PR-957 demonstrates potential in alleviating rheumatoid arthritis by targeting LMP7-mediated CD4+ T cell imbalances, offering a promising avenue for therapeutic intervention. [Read the Full Post]

Unlocking the potential of approved drugs for the allosteric inhibition of tropomyosin-receptor kinase A using molecular docking and molecular dynamics studies

191 views | Dec 04 2023

The study identified delanzomib and tibalosin as potential allosteric inhibitors of TrkA through molecular docking and dynamics simulations, offering promising candidates for experimental evaluation in cancer therapy due to their stable interactions and high binding affinities. [Read the Full Post]

A Reliable and Effective UPLC-MS/MS Method for the Determination of Oprozomib in Rat Plasma

236 views | Nov 10 2023

In this experiment, a sensitive UPLC-MS/MS method was successfully validated for quantifying oprozomib concentrations in rat plasma, demonstrating its suitability for pharmacokinetic studies and potential use in assessing the treatment of haematological malignancies, including relapsed refractory multiple myeloma. [Read the Full Post]

pH-sensitive smart indicators based on cellulose and different natural pigments for tracing kimchi ripening stages

688 views | Jul 27 2023

The study found that cellulose-based pH-sensitive indicators loaded with natural pigments showed more pronounced color changes in response to lactic acid and pH variations, with alkalized indicators being particularly effective for monitoring the fermentation process of acidic foods such as kimchi. [Read the Full Post]

Targeting mitochondrial energetics reverses panobinostat- and marizomib-induced resistance in pediatric and adult high-grade gliomas

142 views | Jun 12 2023

This study investigates the molecular mechanisms and vulnerabilities associated with acquired resistance to the combination therapy of panobinostat and marizomib in high-grade gliomas, highlighting the importance of targeting glycolysis and mitochondrial function to overcome resistance. [Read the Full Post]

Proteasome inhibitors in medullary thyroid carcinoma: time to restart with clinical trials?

171 views | Jun 11 2023

This review summarizes the available in vitro and in vivo data on the role of proteasome inhibitors (PrIn) in medullary thyroid cancer (MTC) and highlights the need for further clinical trials to explore their potential as a treatment option for MTC patients. [Read the Full Post]

The cytotoxic activity of carfilzomib together with nelfinavir is superior to the bortezomib/nelfinavir combination in non-small cell lung carcinoma

285 views | Apr 09 2023

Combining carfilzomib with nelfinavir shows superior efficacy in inducing proteotoxicity and endoplasmic reticulum stress in non-small-cell-lung carcinoma (NSCLC) compared to the combination of bortezomib and nelfinavir, and may represent a future treatment option for NSCLC. [Read the Full Post]

Age-related cataract: GSTP1 ubiquitination and degradation by Parkin inhibits its anti-apoptosis in lens epithelial cells

211 views | Mar 26 2023

This study demonstrates that oxidative stress-induced apoptosis of lens epithelial cells in age-related cataract is regulated by E3 ligase Parkin-mediated degradation of GSTP1, providing potential targets for ARC therapy. [Read the Full Post]

Molecular Cardiotoxic Effects of Proteasome Inhibitors Carfilzomib and Ixazomib and Their Combination with Dexamethasone Involve Mitochondrial Dysregulation

321 views | Mar 16 2023

The study suggests that proteasome inhibitors may cause cardiotoxicity through stress response and mitochondrial dysfunction, which highlights the need for further studies to develop strategies to minimize their side effects. [Read the Full Post]

Change in Cutibacterium acnes phylotype abundance and improvement of clinical parameters using a new dermocosmetic product containing Myrtus communis and Celastrol enriched plant cell culture extracts in patients with acne vulgaris

361 views | Feb 15 2023

The new dermocosmetic product containing Myrtus communis and Celastrol-enriched plant cell culture extracts improved acne severity by decreasing pro-pathogen phylotype IC and increasing non-pathogen phylotype IB of Cutibacterium acnes and decreasing acne lesion count and improving the Global Evaluation Acne score. [Read the Full Post]