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PI3K/Akt/mTOR
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Epigenetics
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Methylation
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Immunology & Inflammation
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Protein Tyrosine Kinase
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Autophagy
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ER stress & UPR
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JAK/STAT
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MAPK
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Cytoskeletal Signaling
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Cell Cycle
- CDK
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- Ras
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TGF-beta/Smad
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DNA Damage/DNA Repair
- HDAC
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- Nucleoside Analog/Antimetabolite
- LIM kinase
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Stem Cells & Wnt
- GSK-3
- JAK
- STAT
- TGF-beta/Smad
- Wnt/beta-catenin
- ROCK
- Hedgehog/Smoothened
- PKA
- KLF
- OCT
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- Fascin
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- Notch
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Hippo
- TEAD
- MAP4K
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Ubiquitin
- Proteasome
- DUB
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- E2 conjugating
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- p97
- E1 Activating
Neuronal Signaling
- Calcium Channel
- Beta Amyloid
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- AChR
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- P-gp
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- Cannabinoid Receptor
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- CGRP Receptor
- MT Receptor
- MAO
- FAAH
- GlyT
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- CaMK
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- Trk receptor
- Adenosine Deaminase
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- Adenosine Kinase
- BChE
- EAAT
- Neurokinin Receptor
- Notch
- Imidazoline Receptor
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- NPY receptor
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- COMT
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NF-κB
- HDAC
- NF-κB
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- ROS
- NOD
- MALT
- Nrf2
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GPCR & G Protein
- Ras
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- CCR
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- Adrenergic Receptor
- AChR
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- Opioid Receptor
- GPR
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- Endothelin Receptor
- S1P Receptor
- Hedgehog/Smoothened
- SGLT
- LPA Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- PAFR
- PKA
- CaSR
- TAAR
- Glucagon Receptor
- LTR
- Adenosine Receptor
- Vasopressin Receptor
- cAMP
- CXCR
- PKD
- TSH Receptor
- Neurokinin Receptor
- GNRH Receptor
- PKG
- CRFR
- Angiotensin Receptor
- Bradykinin Receptor
- Imidazoline Receptor
- Bombesin Receptor
- RGS
- Neurotensin Receptor
- Sigma Receptor
- Melanocortin Receptor
- PAR
- Taste Receptor
- NPY receptor
- Parathyroid Hormone Receptor
- DOCK
- AdipoR
- GPCR19
- Guanylate Cyclase
- GHSR
- CCK receptor
- GRK
- Leukotriene
- FPR
- Prostaglandin Receptor
Endocrinology & Hormones
- Adrenergic Receptor
- 5-alpha Reductase
- Estrogen/progestogen Receptor
- Androgen Receptor
- RAAS
- Opioid Receptor
- Aromatase
- GPR
- Glucocorticoid Receptor
- SSTR
- GHSR
- CCK receptor
- PGES
- TSH Receptor
- GNRH Receptor
- PGDS
- Mineralocorticoid Receptor
- THR
- ACE
Transmembrane Transporters
- CD markers
- Calcium Channel
- Sodium Channel
- ATPase
- Chloride Channel
- Potassium Channel
- GluR
- AChR
- GABA Receptor
- P-gp
- Proton Pump
- CFTR
- P2 Receptor
- SGLT
- GLUT
- GlyT
- NMDAR
- OCT
- CRM1
- Amino acid transporter
- Mechanosensitive Channel
- OAT
- NKCC
- BCRP
- NCX
- OATP
- TRP Channel
- VRAC
- Aquaporin
- EAAT
- VDAC
- MTP
- VMAT
- GlyR
- MCT
Metabolism
- PPAR
- P450 (e.g. CYP17)
- HSP (HSP90)
- PDE
- Hydroxylase
- Factor Xa
- DHFR
- Aminopeptidase
- Dehydrogenase
- Procollagen C Proteinase
- Phospholipase (e.g. PLA)
- DPP
- Carbonic Anhydrase
- Phosphorylase
- Liver X Receptor
- FAAH
- Acyltransferase
- Retinoid Receptor
- Thioredoxin
- FXR
- Transferase
- Serine/threonin kinase
- CETP
- IDO/TDO
- phosphatase
- GLUT
- HMG-CoA Reductase
- Vitamin
- PKM
- Lipoxygenase
- FOX
- Lipase
- Fatty Acid Synthase
- LDL
- NAMPT
- Casein Kinase
- Decarboxylase
- Adenosine Deaminase
- Aldose Reductase
- CPSase
- Leukotriene
- Adenosine Kinase
- OXPHOS
- Glutathione
- Acetyl-CoA carboxylase
- Mitochondrial Metabolism
- Peroxidases
- SHIP
- PCSK9
- PGDS
- Mitochondrial pyruvate carrier
- PREP
- PP2A
- Neprilysin
- RUNX
- FTO
- AdipoR
- PAD
- SREBP
- SCD
- CPT
- AP-1
- LDH
- Carbohydrate Metabolism
- CAR
- PAI-1
- γGCS
- SSTR
- ATP-citrate lyase
- FAO
- FTase
- SOD
- 3-MST
- GTPCH
- SGK
- GOT
- Serine hydrolase
- Epoxide Hydrolase
- glucocerebrosidase
- FABP
- Catalase
- THR
- ACSS2
- ROR
- Glucosylceramide Synthase
- ACE
- Thioredoxin Reductase
- PDHK
- PARG
- Xanthine Oxidase
- Mannosidase
- PGC-1α
Proteases
- HDAC
- Proteasome
- Caspase
- Aminopeptidase
- HCV Protease
- DPP
- HIV Protease
- MMP
- Thrombin
- Acyltransferase
- MALT
- Glutaminase
- Tyrosinase
- Serine Protease
- Cysteine Protease
- Cathepsin B
- PGDS
- Neprilysin
- SGK
- PREP
- GOT
- 3C-Like Protease
- PAD
- PCSK9
- Secretase
Microbiology
- HCV Protease
- Integrase
- Reverse Transcriptase
- HIV Protease
- Anti-infection
- Influenza Virus
- Ribosomal Peptidyl Transferase
- SARS-CoV
- RSV
- HPV
- HSV
- HCV
- HBV
- HIV
- Fungal
- CMV
- Neuraminidase
- Parasite
- Thioredoxin Reductase
- Antiviral
- β-lactamase
- Bacterial
- 3C-Like Protease
- Antibiotics
- Enterovirus
- COVID-19
Others
- ADC Cytotoxin
- ADC Linker
- Drug-Linker Conjugates for ADC
- Antineoplastic and Immunosuppressive Antibiotics
- Selection Antibiotics for Transfected Cell
- Antibiotics for Mammalian Cell Culture
- Antibiotics for Plant Cell Culture
- Hydrotropic Agents
- Dyes
- PROTAC
- PROTAC Linker
- E3 ligase Ligand
- Target Protein Ligand
- Others
- Antibody-Drug Conjugate

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JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit

165 views | Jun 25 2023

The study demonstrates that Jumonji C domain-containing protein 6 (JMJD6) protects against pathological cardiac hypertrophy by interacting with NF-κB p65, inhibiting its nuclear translocation, and demethylating histone substrates, suggesting JMJD6 as a potential therapeutic target for cardiac hypertrophy and heart failure. [Read the Full Post]