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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

NOS

Three new phenolic glycosides and a new lignan glycoside from Gaultheria leucocarpa var. yunnanensis

86 views | Feb 09 2024

Compounds isolated from Gaultheria leucocarpa var. yunnanensis demonstrated significant anti-inflammatory and antioxidant properties, with compounds 7 and 8 showing promising inhibitory effects against LPS-induced NO production and compound 7 exhibiting notable DPPH radical scavenging activity. [Read the Full Post]

The protective effects of NE 52-QQ57 against interleukin-33-induced inflammatory response in activated synovial mast cells

535 views | Oct 09 2023

The study suggests that inhibiting GPR4 signaling with the antagonist NE 52-QQ57 may have therapeutic benefits in rheumatoid arthritis by reducing inflammatory responses and oxidative stress in synovial mast cells. [Read the Full Post]

Involvement of a flavoprotein, acetohydroxyacid synthase, in growth and riboflavin production in riboflavin-overproducing Ashbya gossypii mutant

339 views | Aug 16 2023

This study demonstrates that branched-chain amino acids, particularly through the regulation of acetohydroxyacid synthase, play a crucial role in enhancing riboflavin production in the Ashbya gossypii mutant strain, offering a novel approach for optimizing riboflavin production in this organism. [Read the Full Post]

1400 W, a selective inducible nitric oxide synthase inhibitor, mitigates early neuroinflammation and nitrooxidative stress in diisopropylfluorophosphate-induced short-term neurotoxicity rat model

91 views | Jul 29 2023

1400W treatment at 15 mg/kg per day for two weeks significantly reduces DFP-induced nitrooxidative stress, neuroinflammation, and neurodegenerative changes, but does not significantly impact epileptiform spike rate or spontaneous seizures. [Read the Full Post]

Endothelial Histone Deacetylase 1 Activity Impairs Kidney Microvascular NO Signaling in Rats fed a High Salt Diet

90 views | Apr 10 2023

The study found that a high salt diet impairs NO signaling in kidney microvascular endothelial cells through an HDAC1-dependent mechanism activated by a humoral factor called Plasma Derived Endothelial-dysfunction Mediator (PDEM). [Read the Full Post]