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PCSK9

PCSK9 Inhibition Regulates Infarction-Induced Cardiac Myofibroblast Transdifferentiation via Notch1 Signaling

157 views | Jul 09 2023

SBC-115076, a PCSK9 inhibitor, was found to mitigate cardiac fibrosis and improve ventricular function after myocardial infarction by inhibiting the differentiation of cardiac fibroblasts to myofibroblasts through the Notch1/Hes1 signaling pathway. [Read the Full Post]

A proprotein convertase subtilisin/kexin type 9 inhibitor provides comparable efficacy with lower detriment than statins on mitochondria of oxidative muscle of obese estrogen-deprived rats

525 views | Apr 06 2021

Chanisa Thonusin et al. showed that 17β-Estradiol exhibited the greatest efficacy on the attenuation of obesity with the least harmful effect on skeletal muscle in a model of menopause with obesity, yet its effect on the treatment of hyperlipidemia was inferior to those of standard lipid-lowering agents. [Read the Full Post]