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DDR

Simultaneous inhibition of discoidin domain receptor 1 and integrin αVβ3 radiosensitizes human glioblastoma cells

130 views | Jan 14 2024

This study highlights that the combined inhibition of DDR1, integrin αVβ3, and integrin αVβ5 effectively diminishes radioresistance in human glioblastoma cells by disrupting clonogenicity, enhancing cellular radiosensitivity, and impeding DNA repair mechanisms. [Read the Full Post]

Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical and Clinical Findings, and Signal Transduction Correlates

0 views | Nov 01 2023

The study demonstrated that the combination of the MET inhibitor merestinib with the FGFR inhibitor LY2874455 showed preliminary safety and biological activity, indicating the potential of targeting MET and FGFR pathways in the treatment of relapsed/refractory acute myeloid leukemia. [Read the Full Post]