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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Fatty Acid Synthase

Topical non-aqueous nanoemulsion of Alpinia galanga extract for effective treatment in psoriasis: In vitro and in vivo evaluation

81 views | Nov 24 2023

A non-aqueous nanoemulsion of Alpinia galanga extract, optimized using a Box-Behnken design, exhibited a 10-fold increase in skin permeation compared to the extract alone, confirming its efficacy in ameliorating psoriasis in an IMQ-induced mouse model via trans-follicular transport mechanism. [Read the Full Post]

FASN inhibition targets multiple drivers of NASH by reducing steatosis, inflammation and fibrosis in preclinical models

157 views | Nov 15 2023

FASN inhibition demonstrates promising potential as a therapeutic strategy for NASH by targeting multiple hallmarks of the disease, including reducing hepatic fat accumulation, mitigating inflammation, and attenuating fibrosis. [Read the Full Post]

Atomic model for core modifying region of human fatty acid synthase in complex with Denifanstat

92 views | Sep 21 2023

Researchers have developed an engineered full-length human Fatty Acid Synthase (hFASN) protein, enabling the study of specific regions involved in fatty acid modification and providing insights for the design of small molecule inhibitors targeting hFASN in diseases such as diabetes, cancer, fatty liver diseases, and viral infections. [Read the Full Post]

Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy

103 views | Aug 12 2023

The study demonstrates that combining MAPK inhibitors, FASN inhibitors, and ROS-inducing compounds increases lipid poly-unsaturation and overcomes therapy resistance, leading to improved survival in BRAF-mutant melanoma. [Read the Full Post]

LATS-regulated nuclear-cytoplasmic translocation of SREBP2 inhibits hepatocellular carcinoma cell migration and invasion via epithelial-mesenchymal transition

105 views | Jul 27 2023

The study demonstrates that high expression of SREBP2 in hepatocellular carcinoma (HCC) is associated with poor prognosis and promotes HCC cell invasion and metastasis through the epithelial-mesenchymal transition (EMT) process, suggesting SREBP2 as a potential therapeutic target for HCC. [Read the Full Post]

Visfatin-induced upregulation of lipogenesis via EGFR/AKT/GSK3β pathway promotes breast cancer cell growth

114 views | Jul 27 2023

Visfatin induces lipid synthesis and accumulation in breast cancer cells through activation of the EGFR/AKT/GSK3β pathway, promoting cell survival and proliferation. [Read the Full Post]

Development and Optimisation of Inhalable EGCG Nano-Liposomes as a Potential Treatment for Pulmonary Arterial Hypertension by Implementation of the Design of Experiments Approach

410 views | Mar 21 2023

The research developed an inhalable EGCG nano-liposome formulation with desirable properties and demonstrated its potential effectiveness in treating PAH by inhibiting the TGFβ pathway. [Read the Full Post]

Chronic AMPK Activation Reduces the Expression and Alters Distribution of Synaptic Proteins in Neuronal SH-SY5Y Cells

176 views | Aug 29 2022

Alex J T Yang et al. suggested that chronic AMPK activation impacted synaptic protein content and reduced neurite protein abundance and distribution. [Read the Full Post]

Structural basis of the selective activation of enzyme isoforms: Allosteric response to activators of β1- and β2-containing AMPK complexes

897 views | Oct 06 2021

Elnaz Aledavood et al. found the design of activators tailored for improving the therapeutic treatment of tissue-specific metabolic disorders. [Read the Full Post]

Myeloid deletion and therapeutic activation of AMPK do not alter atherosclerosis in male or female mice

681 views | Oct 02 2020

Nicholas D LeBlond et al. suggested that intervention with the first-generation AMPK activator A-769662 was not able to stem the progression of atherosclerosis. [Read the Full Post]