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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

IGF-1R

Sperm-carried IGF2 downregulated the expression of mitogens produced by Sertoli cells: A paracrine mechanism for regulating spermatogenesis?

0 views | Dec 14 2023

The presence of IGF2 protein in human spermatozoa influences the expression of mitogens and reproductive hormones in Sertoli cells, indicating a paracrine regulatory mechanism that impacts gonocyte proliferation and spermatogonial fate during spermatogenesis. [Read the Full Post]

Sperm-carried IGF2 downregulated the expression of mitogens produced by Sertoli cells: A paracrine mechanism for regulating spermatogenesis?

0 views | Dec 14 2023

The presence of IGF2 protein in human spermatozoa influences the expression of mitogens and reproductive hormones in Sertoli cells, indicating a paracrine regulatory mechanism that impacts gonocyte proliferation and spermatogonial fate during spermatogenesis. [Read the Full Post]

Sperm-carried IGF2 downregulated the expression of mitogens produced by Sertoli cells: A paracrine mechanism for regulating spermatogenesis?

112 views | Dec 14 2023

The presence of IGF2 protein in human spermatozoa influences the expression of mitogens and reproductive hormones in Sertoli cells, indicating a paracrine regulatory mechanism that impacts gonocyte proliferation and spermatogonial fate during spermatogenesis. [Read the Full Post]

PI3K pathway mutation predicts an activated immune microenvironment and better immunotherapeutic efficacy in head and neck squamous cell carcinoma

82 views | Dec 10 2023

*PI3K pathway mutations in head and neck squamous cell carcinoma patients are associated with significantly extended overall survival and enhanced immunotherapeutic responses, indicating their potential as a valuable biomarker for clinical prognosis and treatment outcomes.* [Read the Full Post]

Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis

111 views | Nov 06 2023

The MLX-Q139R mutation in the MLX gene plays a crucial role in the pathogenesis of Takayasu arteritis by promoting inflammasome formation, increased oxidative stress, and impaired autophagy. [Read the Full Post]

Advances in lung adenocarcinoma: A novel perspective on prognoses and immune responses of CENPO as an oncogenic superenhancer

112 views | Nov 05 2023

This study reveals that the overexpression of Centromere protein O (CENPO) in lung adenocarcinoma is associated with a poor prognosis, and its involvement in immunosuppression and drug resistance highlights its potential as a prognostic biomarker and therapeutic target. [Read the Full Post]

A narrative review from gut to lungs: non-small cell lung cancer and the gastrointestinal microbiome

445 views | Jul 24 2023

The gut microbiome plays a crucial role in modulating the immune response and therapeutic outcomes in lung cancer, highlighting the potential for microbiome-based interventions to improve treatment efficacy. [Read the Full Post]

Inhibition of LAR attenuates neuroinflammation through RhoA/IRS-1/Akt signaling pathway after intracerebral hemorrhage in mice

174 views | Jul 24 2023

This study revealed that leukocyte common antigen-related phosphatase (LAR) contributes to neuroinflammation after intracerebral hemorrhage (ICH) via the RhoA/IRS-1 pathway, and the administration of an extracellular LAR peptide (ELP) may serve as a potential therapeutic strategy to attenuate LAR-mediated neuroinflammation following ICH. [Read the Full Post]

Effect of insulin-like growth factor system on luteinising angiogenesis

193 views | Jun 21 2023

This study found that while exogenous IGF1 and IGF2 had limited effects on luteinizing follicular angiogenesis and progesterone production, inhibiting the IGF1 receptor signaling significantly reduced endothelial cell growth and progesterone concentration, indicating its crucial role in these processes. [Read the Full Post]

Glycolytic System in Axons Supplement Decreased ATP Levels after Axotomy of the Peripheral Nerve

98 views | Jun 10 2023

The study demonstrates that the glycolytic system in both Schwann cells and axons is the main source of ATP maintenance in the distal nerve stump during Wallerian degeneration, highlighting its significance in neurologic therapies. [Read the Full Post]