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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

AhR

Effects of different chronic restraint stress periods on anxiety- and depression-like behaviors and tryptophan-kynurenine metabolism along the brain-gut axis in C57BL/6N mice

97 views | Feb 10 2024

Prolonged chronic stress induces anxiety and depression-like behaviors while altering the tryptophan-kynurenine metabolism in a manner that shifts towards neurotoxicity, highlighting the complex impact of stress duration on behavior and neurochemistry in mice. [Read the Full Post]

Human CYP1B1 enzyme-mediated, AhR enhanced activation of aflatoxin B1 for its genotoxicity in human cells

103 views | Dec 21 2023

This study demonstrates that human CYP1B1 metabolically activates aflatoxin B1 through the aryl hydrocarbon receptor (AhR) signaling pathway, resulting in increased genotoxic effects in human hepatocytes and lymphoblastoid cells. [Read the Full Post]

Topical Management of Pediatric Psoriasis: A Review of New Developments and Existing Therapies

154 views | Dec 09 2023

The recent approval of topical agents like Roflumilast and Tapinarof, along with ongoing research into various targeted therapies and optimized formulations, represents a promising shift in the management of pediatric psoriasis, offering diverse and potentially more effective treatment options for young patients. [Read the Full Post]

Aryl hydrocarbon receptor is regulated via multiple mechanisms in human keratinocytes

90 views | Sep 30 2023

The study reveals that the Aryl hydrocarbon receptor (AhR) is primarily regulated through proteasomal degradation, ligand-induced and ARNT-dependent mechanisms, as well as transcriptional regulation by HDACs, indicating a complex system for controlling AhR expression and protein stability in epidermal keratinocytes. [Read the Full Post]

Role of Aryl Hydrocarbon Receptor and Oxidative Stress in the Regioselective Toxicities of Hydroxychrysenes in Embryonic Japanese Medaka (Oryzias latipes)

201 views | Jun 23 2023

The study suggests that the toxicity of 2-hydroxychrysene (2-OHCHR) in embryonic Japanese medaka is mediated by aryl hydrocarbon receptor (AhR) activation, up-regulation of cytochrome P450 enzymes, and the generation of reactive oxygen species, leading to anemia and mortality. [Read the Full Post]

Investigation of gait, balance and lower extremity muscle activity during walking in patients with cervical spondylotic myelopathy using wearable sensors

162 views | Apr 10 2023

The study found that wearable sensors can detect changes in gait, balance, and lower extremity muscle activity in patients with CSM compared to age-matched healthy controls, suggesting potential for diagnosis and monitoring of CSM disease using wearable technology. [Read the Full Post]

The monoculture of cord-blood-derived CD34+ cells by an automated, membrane-based dynamic perfusion system with a novel cytokine cocktail

96 views | Apr 09 2023

The provided information describes an automated expansion protocol for cord blood-derived CD34+ cells, which can provide a sufficient number of T cell-depleted hematopoietic stem and progenitor cells for use in HLA-matched cord blood transplantation, with minimal residual lymphocytes. [Read the Full Post]

Anti-inflammatory effects of first-line anti-arthritic drugs on T-cell activation

154 views | Feb 13 2023

Anti-arthritic drugs can inhibit pro-inflammatory cytokines and potentially stimulate a Th2 response to inhibit the progression of the immune response, as seen in the study examining their in vitro effects on early stages of T-cell activation. [Read the Full Post]

[TRANSLATED ARTICLE] Biological and immunosuppressive medications in pregnancy, breastfeeding and fertility in immune mediated diseases

232 views | Feb 12 2023

The objective of this review was to gather available evidence on drugs used in immune-mediated inflammatory diseases during pregnancy and lactation, their impact on fertility, and to provide advice on family planning based on analyzed studies until April 2020. [Read the Full Post]

Effects of natural 24-epibrassinolide on inducing apoptosis and restricting metabolism in hepatocarcinoma cells

171 views | Sep 26 2022

Hongfei Zhou et al. suggested that EBR could be considered as a potential therapeutic compound for HCC due to its pro-apoptosis, restriction of energy metabolism, and other anti-cancer properties. [Read the Full Post]