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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

TBK1

Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection

120 views | Nov 28 2023

In this study, researchers discovered that the small molecule idronoxil inhibits TBK1/IKKε signaling, attenuating hyper-inflammation in SARS-CoV-2-challenged mice and establishing a critical role for TBK1/IKKε signaling in severe COVID-19 pathology. [Read the Full Post]

Promotion of Knee Cartilage Degradation by IκB Kinase ε in the Pathogenesis of Osteoarthritis in Human and Murine Models

103 views | Sep 10 2023

The study demonstrates that IKKε regulates cartilage degradation in osteoarthritis through NF-κB signaling and suggests that IKKε inhibition, exemplified by BAY-985, may serve as an effective modulatory treatment for the disease. [Read the Full Post]

Efficient and Stable β-CsPbI3 Solar Cells through Solvent Engineering with Methylamine Acetate Ionic Liquid

201 views | Sep 09 2023

The utilization of MAAc solvent and the incorporation of strong C═O···Pb coordination enabled the controllable growth of β-CsPbI3 perovskite thin films with a compact morphology and facilitated the achievement of efficient and stable perovskite solar cells (PSCs) with an efficiency of 18.9% and improved stability even in humid environments. [Read the Full Post]

Establishment and characterization of Yellow River carp (Cyprinus carpio haematopterus) muscle cell line and its application to fish virology and immunology

229 views | Sep 09 2023

This study presents the establishment of a novel Yellow River carp muscle cell line (CCM) and explores its immune response strategies to lipopolysaccharide (LPS) and poly (I:C), providing a valuable tool for fish immunology research. [Read the Full Post]

Serine/threonine kinase TBK1 promotes cholangiocarcinoma progression via direct regulation of β-catenin

190 views | Sep 04 2023

TBK1 shows increased expression in cholangiocarcinoma and promotes tumor growth and metastasis by interacting with β-catenin, suggesting its potential as a prognostic biomarker and therapeutic target. [Read the Full Post]

Therapeutic targeting of TANK-binding kinase signaling towards anticancer drug development: Challenges and opportunities

249 views | Aug 10 2022

Manzar Alam et al. highlighted the therapeutic potential of potent and selective TBK1 inhibitors, including Amlexanox, Compound II, BX795, MRT67307, SR8185 AZ13102909, CYT387, GSK8612, BAY985, and Domainex. [Read the Full Post]

Transient blockade of TBK1/IKKε allows efficient transduction of primary human natural killer cells with vesicular stomatitis virus G-pseudotyped lentiviral vectors

483 views | Mar 24 2022

Peter Chockley et al. found that inhibition of TBK1/IKKε enabled the reliable generation of genetically modified NK cells using VSV-G LVs. [Read the Full Post]

DNA damage-triggered activation of cGAS-STING pathway induces apoptosis in human keratinocyte HaCaT cells

699 views | Apr 12 2021

Can Li et al. concluded that NF-κB pathway and IFNβ pathway residing in the downstream of STING were resposible for apoptosis of UVB-irradiated or cisplatin-treated HaCaT cells. [Read the Full Post]