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Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

118 views | Dec 01 2023

The study elucidates the role of NUDT5 in ADP-ribose metabolism and hormone-dependent gene regulation in breast cancer cells, presenting TH5427 as a potent inhibitor that blocks nuclear ATP synthesis, chromatin remodeling, and proliferation, highlighting its potential for targeted therapy and further research. [Read the Full Post]