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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Integrin

225Ac-iPSMA-RGD for Alpha-Therapy Dual Targeting of Stromal/Tumor Cell PSMA and Integrins

118 views | Jan 30 2024

The preclinical evaluation of 225Ac-iPSMA-RGD demonstrates its cytotoxicity, biodistribution, and therapeutic potential, suggesting promise for targeted alpha therapy in treating colorectal cancer. [Read the Full Post]

Regulation of the integrin αVβ3- actin filaments axis in early osteogenic differentiation of human mesenchymal stem cells under cyclic tensile stress

117 views | Jan 20 2024

Cyclic tensile stress influences early osteogenesis in human mesenchymal stem cells through the integrin αVβ3-actin filaments axis while involving nuclear localization of YAP. [Read the Full Post]

Leukadherin-1 inhibits NLRP3 inflammasome by blocking inflammasome assembly

204 views | Jan 15 2024

Leukadherin-1 (LA-1) demonstrates potent inhibition of NLRP3 inflammasome activation through specific mechanisms, suggesting its potential as a targeted treatment for NLRP3-associated inflammatory diseases. [Read the Full Post]

Pyrintegrin Induces Soft Tissue Formation by Transplanted or Endogenous Cells

100 views | Dec 06 2023

The experimental study demonstrates that Pyrintegrin (Ptn) promotes robust adipogenesis both in vitro and in vivo, suggesting its potential therapeutic application in soft tissue reconstruction and augmentation by inducing the formation of adipose tissue from transplanted and endogenous cells. [Read the Full Post]

Virtual screening indicates potential inhibitors of the P2X7 receptor

112 views | Nov 14 2023

The passage discusses the search for natural and synthetic anti-inflammatory compounds, highlighting the identification of potential P2X7 receptor inhibitors, including flavonoids and drugs, through virtual screening and subsequent in vitro validation. [Read the Full Post]

Preparation and Properties of Natural Polysaccharide-Based Drug Delivery Nanoparticles

288 views | Oct 05 2023

The paper presents the development of RGD-(NPGP/CS)3NPGP nanoparticles through layer-by-layer assembly, which demonstrate high encapsulation efficiency, pH-sensitive release, and effective targeting to integrin receptor-expressing tumor cells, making them promising as novel anticancer drug carriers. [Read the Full Post]

Modulation of gene expression on a transcriptome-wide level following human neural stem cell transplantation in aged mouse stroke brains

86 views | Aug 04 2023

This study demonstrates that transplantation of human neural stem cells (NSCs) in aged mice after stroke reduces infarct size, modulates proinflammatory factors and matrix metalloproteases, and induces differential expression of genes and pathways associated with neuroinflammation, cell adhesion, and matrix remodeling. [Read the Full Post]

Prostate cancer cell‑derived spondin 2 boosts osteogenic factor levels in osteoblasts via the PI3K/AKT/mTOR pathway

155 views | Aug 04 2023

Spondin 2 promotes osteogenesis in prostate cancer by activating the PI3K/AKT/mTOR pathway and involving the integrin receptor α5β1. [Read the Full Post]

Synthesis of Novel Carborane-Containing Derivatives of RGD Peptide

199 views | Jul 11 2023

Carborane derivatives of the N- and C-protected RGD peptide containing a glutaric acid residue as a linker fragment have demonstrated potential as starting compounds for the synthesis of unprotected or selectively protected peptides and as building blocks for the development of more complex boron-containing derivatives of the RGD peptide for targeted delivery in tumor treatment, such as glioblastoma. [Read the Full Post]

Cell recognitive bioadhesive-based osteogenic barrier coating with localized delivery of bone morphogenetic protein-2 for accelerated guided bone regeneration

208 views | Jul 11 2023

A bioengineered mussel adhesive protein (MAP) fused with an Alg-Gly-Asp (RGD) peptide coating on titanium mesh (Ti-mesh) enables effective cell occlusion, localized delivery of bone morphogenetic protein-2 (BMP-2), and accelerated bone regeneration, making it a promising approach for guided bone regeneration (GBR) treatments. [Read the Full Post]