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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Hedgehog/Smoothened

Anna Karenina principle in personalized treatment of bladder cancer according to oncogram: which drug for which patient?

143 views | Jun 28 2023

The ex vivo application of chemotherapy, immunotherapy, and targeted agents using the oncogram method showed higher good response rates compared to the control group in bladder cancer patients, with variations observed on a per-patient basis. [Read the Full Post]

Solubilization, purification, and ligand binding characterization of G protein-coupled receptor SMO in native membrane bilayer using styrene maleic acid copolymer

135 views | May 21 2023

The study demonstrates the use of SMA-nanodiscs to solubilize and purify the SMO transmembrane domain in a native-like lipid environment for investigating the structure, function, and drug development of SMO proteins. [Read the Full Post]

Effects of Modulation of the Hedgehog and Notch Signaling Pathways on Osteoblast Differentiation Induced by Titanium with Nanotopography

183 views | Apr 15 2023

This study demonstrates that Hedgehog and Notch signalling pathways modulate osteoblast differentiation and regulate receptor expression on nanostructured titanium surfaces, with synergistic effects observed with the combination of Hedgehog activation and Notch inhibition. [Read the Full Post]

CRC Therapy Identifies Indian Hedgehog Signaling in Mouse Endometrial Epithelial Cells and Inhibition of Ihh-KLF9 as a Novel Strategy for Treating IUA

148 views | Jan 12 2023

Xinhao Zhou et al. suggested a promising application of hedgehog inhibitors as a targeted drug in the IUA clinic. [Read the Full Post]

Novel Approaches in Non-Melanoma Skin Cancers-A Focus on Hedgehog Pathway in Basal Cell Carcinoma (BCC)

163 views | Nov 16 2022

Paulina Chmiel et al. thought that a central role in the development of BCC was played by the Hedgehog (Hh) signalling pathway. [Read the Full Post]

Current approaches and strategies to identify Hedgehog signaling pathway inhibitors for cancer therapy

220 views | Nov 15 2022

Zifan Feng et al. gave a systematic overview of the current status and characteristics of various approaches to developing the Hedgehog pathway inhibitors. [Read the Full Post]

Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma

193 views | Nov 10 2022

Anthony Tam et al. found that TGFβ1-induced airway remodeling was partially mediated through the hedgehog signaling pathway via the PTCH1-SMO-GLI axis. [Read the Full Post]

Identification of solamargine as a cisplatin sensitizer through phenotypical screening in cisplatin-resistant NSCLC organoids

207 views | Sep 02 2022

Yi Han et al. found that a new direction for further treatment of advanced DDP-resistant lung cancer patients. [Read the Full Post]

Giant Basal Cell Carcinoma of the Axilla: 8-year Follow-up of a Case Treated with Excision, Vismodegib, and Radiotherapy

194 views | Jul 05 2022

Shih-Chiang Kuo et al. illustrated a rare disease with an 8-year follow-up, involving different therapeutic strategies against multiple recurrences. [Read the Full Post]

Treatment patterns, effectiveness, and patient-reported outcomes of palbociclib therapy in Chinese patients with advanced breast cancer: A multicenter ambispective real-world study

304 views | Apr 28 2022

Lesang Shen et al. thought that Palbociclib was effective for front-line use and for treating endocrine-sensitive patients in real-world China and was generally well tolerated. [Read the Full Post]