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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Glucocorticoid Receptor

Age- and sex-adjusted reference intervals for steroid hormones measured by liquid chromatography‑tandem mass spectrometry (LC-MS/MS) using a widely available kit

127 views | Dec 18 2023

This study established reference intervals for nine endogenous steroids using a commercially available liquid chromatography-tandem-mass-spectrometry (LC MS/MS) kit, revealing age and sex as major determinants of steroid levels while highlighting limitations in sensitivity for certain compounds, thereby providing valuable insights for interpreting steroid profiles in routine laboratory analyses. [Read the Full Post]

Effect of 11-Deoxycorticosterone in the Transcriptomic Response to Stress in Rainbow Trout Skeletal Muscle

214 views | Mar 26 2023

The study demonstrates the role of 11-deoxycorticosterone (DOC) in modulating the stress response of skeletal muscles in rainbow trout and highlights its differential modulation by glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), complementing the action of cortisol. [Read the Full Post]

Evaluation of Pain and Use of Analgesics during Medical Termination of Pregnancy in Real-Life Settings

338 views | Mar 25 2023

This study evaluated pain related to medical termination of pregnancy (MToP) and its management in 23 centers in France, finding that higher doses of misoprostol were strongly associated with both pain and curative analgesic intake, while analgesic prophylaxis prescription was associated with a decreased risk of curative analgesic intake. [Read the Full Post]

A case of systemic lupus erythematosus having concurrent Evans syndrome and acquired thrombotic thrombocytopenic purpura

145 views | Mar 06 2023

TTP in patients with refractory immune-mediated thrombocytopenia and atypical symptoms. [Read the Full Post]

IgG4 related pericardium and lung disease in pediatric patient complicated with fatal massive hemoptysis: a case report and review of literature

161 views | Mar 06 2023

This case highlights the rarity and severity of pericardio-pulmonary involvement in pediatric IgG4-RD and the potential risks associated with the use of rituximab as a rescue therapy. [Read the Full Post]

Transport of hydrocortisone in targeted layers of the skin by multi-lamellar liposomes

90 views | Mar 04 2023

Encapsulation of hydrocortisone in multi-lamellar liposomes enabled targeted delivery to different skin layers with non-Fickian diffusion observed for formulations targeting the stratum corneum and living epidermis. [Read the Full Post]

A Novel Mutation in Melanocortin Receptor 2 and a Reported Mutation in Melanocortin Receptor 2 Accessory Protein: Three Chinese Cases with Familial Glucocorticoid Deficiency

91 views | Mar 04 2023

This report describes three Chinese patients with familial glucocorticoid deficiency, their different clinical presentations, and the importance of genetic testing for accurate diagnosis and appropriate treatment. [Read the Full Post]

Combination chemotherapy with vincristine (NSC-67574), procarbazine (NSC-77213), prednisone (NSC-10023) with or without nitrogen mustard (NSC-762)(MOPP vs OPP) in children with recurrent brain tumors

120 views | Feb 28 2023

The study compared two chemotherapy regimens in treating recurrent central nervous system tumors in 73 pediatric patients, with the more toxic MOPP producing more responses but not statistically significant differences in duration of response or survival, and with two patients in the MOPP group experiencing fatal myelosuppression. [Read the Full Post]

Traditional and disease-related cardiovascular risk factors in ANCA-associated vasculitis: a prospective, two-centre cohort study

150 views | Feb 28 2023

The study found that age, Framingham risk score, HbA1c level, Diabetes Mellitus (DM), and previous cardiovascular event were significantly associated with cardiovascular events in patients with ANCA-associated vasculitis, highlighting the importance of treating risk factors for optimal long-term outcomes. [Read the Full Post]

16a-Methyl corticosteroids; a new series of anti-inflammatory compounds; clinical appraisal of their antirheumatic potencies

281 views | Feb 16 2023

Four new derivatives of hydrocortisone with a methyl grouping at the 16a-carbon position were synthesized and studied in human subjects for anti-inflammatory activity, with 16a-methyl 9a-fluoroprednisolone showing the highest potency per milligram and potential for long-term therapeutic use. [Read the Full Post]