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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

GluR

Vestibular Testing-New Physiological Results for the Optimization of Clinical VEMP Stimuli

217 views | Feb 12 2024

The review explores the intricate synaptic and receptor mechanisms of auditory and vestibular systems, proposing an "ultrafast" non-quantal transmission as the cause of rapid vestibular afferent responses, with profound implications for clinical testing and understanding neural processing in these sensory pathways. [Read the Full Post]

Content of amino acids and biogenic amines in stored meat as a result of a broiler diet supplemented with β-alanine and garlic extract

204 views | Feb 07 2024

Supplementing chicken feed with garlic extract and β-alanine showed promise in increasing protein content, altering amino acid levels, and potentially reducing biogenic amine formation, improving the quality and shelf life of poultry meat during storage. [Read the Full Post]

Role of ON and OFF Visual Pathways in Rod- and Cone-Driven Flicker Responses

273 views | Jan 28 2024

The study identified distinct neurotransmitter effects on rod and cone-driven flicker responses, emphasizing the involvement of ON and OFF visual pathways, horizontal cells, and the sensitivity of low-frequency flicker in ophthalmic pathophysiological research. [Read the Full Post]

Polyamine metabolism and glutamate receptor agonists-mediated excitotoxicity in the rat brain

246 views | Jan 28 2024

The study compared various glutamate receptor agonists' impact on inducing excitotoxic brain damage in rats, revealing PUT as a potential general marker of such damage due to its concurrent increase with brain injury following both ionotropic and metabotropic glutamate receptor activation. [Read the Full Post]

Spinal Glutamate Transporters Are Involved in the Development of Electroacupuncture Tolerance

1366 views | Dec 16 2018

Cui L et al. indicated the participation of the spinal GTs in EAT. [Read the Full Post]

Riluzole partially rescues age-associated, but not LPS-induced, loss of glutamate transporters and spatial memory

2156 views | Sep 11 2017

Brothers HM et al. showed that highlight the therapeutic potential of reducing glutamatergic function upon memory impairment in neurodegenerative diseases associated with aging. [Read the Full Post]

Resveratrol protects CA1 neurons against focal cerebral ischemic reperfusion-induced damage via the ERK-CREB signaling pathway in rats

2368 views | Sep 13 2016

Li Z, et al. showed that the NMDA receptor-mediated ERK-CREB signaling pathway might participates in Res-induced neuroprotection in rats with focal cerebral ischemia. [Read the Full Post]