Homein vivo Antibodies

in vivo Antibodies

Catalog No. Product Name Application Product Validations Information
A2115 Anti-mouse PD-L1 (B7-H1)-InVivo in vivo PD-L1 blockade,IHC (frozen),FCM Anti-mouse PD-L1 (B7-H1)-InVivo (Clone:10F.9G2) monoclonal antibody reacts with mouse PD-L1 (also known as B7-H1, CD274). The 10F.9G2 antibody has been shown to block the interaction between PD-L1 and PD-1 and between PD-L1 and B7-1 (CD80).
A2122 Anti-mouse PD-1 (CD279)-InVivo Anti-mouse PD-1 (CD279)-InVivo(Clone:RMP1-14) reacts with mouse PD-1 (programmed death-1) also known as CD279. PD-1 is a 50-55 kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the Ig superfamily.
A2102 Anti-mouse CD8α-InVivo In vivo CD8+ T cell depletion,WB Anti-mouse CD8α (Clone:2.43)reacts with mouse CD8α. CD8 is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). It binds to class I MHC molecules displayed by antigen presenting cells (APC).
A2111New Anti-human CD3-InVivo in vitro T cell stimulation/activation, FCM The OKT-3 monoclonal antibody reacts with human CD3ε which is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily.The OKT-3 antibody has immunosuppressive properties in vivo and has been shown to effectively treat renal, heart and liver allograft rejection.
A2101 Anti-mouse CD4-InVivo In vivo CD4+ T cell depletion,FCM,WB Anti-mouse CD4 antibody(Clone: GK1.5) reacts with mouse CD4, which is a 55 kDa cell surface type I membrane glycoprotein. CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells.
A2116 Rat IgG2b isotype control-InVivo Rat IgG2b isotype control-InVivo monoclonal antibody (Clone:LTF-2) reacts with keyhole limpet hemocyanin (KLH). Because KLH is not expressed by mammals this antibody is ideal for use as an isotype-matched control for rat IgG2b antibodies in most in vivo and in vitro applications.
A2110 Anti-mouse CD16/CD32-InVivo in vitro/vivo Fc receptor blocking The 2.4G2 monoclonal antibody (Clone: 2.4G2)reacts specifically with mouse CD16 (FcγRIII) and CD32 (FcγRII). It has also been reported to react non-specifically via its Fc domain to FcγRI. The 2.4G2 antibody is commonly used in flow cytometry staining experiments to prevent non-specific binding of IgG to the FcγIII and FcγII, and possibly FcγI, receptors prior to staining with antigen specific primary antibodies.
A2103New Anti-mouse CTLA-4 (CD152)-InVivo in vivo/vitro CTLA-4 neutralization, FCM,WB Anti-mouse CTLA-4 (CD152) antibody (Clone:9H10) reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. Anti-mouse CTLA-4 (CD152) antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding.
A2120 Anti-mouse IL-17A-InVivo in vivo IL-17A neutralization Anti-mouse IL-17A-InVivo monoclonal antibody (Clone:17F3) reacts with mouse IL-17A which is a 15-20 kDa cytokine expressed by Th17 cells, γδ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. Anti-mouse IL-17A-InVivo has been shown to neutralize IL-17A in vivo.
A2114New Anti-mouse NK1.1-InVivo in vivo NK cell depletion,FCM The PK136 monoclonal antibody(Clone: PK136) reacts with mouse NK1.1 also known as CD161b/CD161c, KLRB1, NKR-P1A and Ly-55.
A2113 Anti-human/mouse TGF-β-InVivo in vivo/vitro TGFβ neutralization,WB The 1D11.16.8 monoclonal antibody reacts with mouse, human, rat, monkey, hamster, canine and bovine TGF-β (transforming growth factor beta) isoforms 1, 2 and 3.The 1D11.16.8 monoclonal antibody is a neutralizing antibody.
A2121 Anti-mouse IFNAR-1-InVivo in vivo IFNAR-1 blockade, in vitro IFNAR-1 blockade, WB Anti-mouse IFNAR-1-InVivo monoclonal antibody (Clone: MAR1-5A3) reacts with mouse IFNAR-1 (IFN alpha/beta receptor subunit 1). Anti-mouse IFNAR-1-InVivo has been shown to inhibit Type I IFN receptor signaling in vitro and in vivo.
A2107 Anti-mouse CD25 (IL-2Rα)-InVivo in vivo regulatory T cell depletion,FCM The PC-61.5.3 monoclonal antibody reacts with mouse IL-2Rα also known as CD25, Ly-43, p55, or Tac.The PC-61.5.3 antibody has been shown to inhibit the binding of IL-2 to both the low and high affinity IL-2 receptor forms. Additionally, the PC-61.5.3 antibody is commonly used to deplete CD4+FoxP3+ T regulatory cells in vivo.
A2117 Mouse IgG2a isotype control-InVivo Mouse IgG2a isotype control-InVivo (Clone:C1.18.4) monoclonal antibody is ideal for use as a non-reactive isotype-matched control for mouse IgG2a antibodies in most in vivo and in vitro applications.
A2104 Anti-mouse CD3ε-InVivo in vitro T cell stimulation/activation, IF, FCM, WB The 145-2C11 monoclonal antibody reacts with mouse CD3ε which is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. The 145-2C11 antibody has been shown to induce T lymphocyte activation, proliferation, and apoptosis in vitro via binding and stimulating the TCR. When used in vivo the antibody is reported to produce T cell activation, anergy, or death.
A2118 Anti-mouse IL-6-InVivo in vivo IL-6 neutralization Anti-mouse IL-6-InVivo monoclonal antibody (Clone:MP5-20F3) can reacts with mouse IL-6 (interleukin-6) which is a 21-28 kDa cytokine that is expressed by many cell types, including T lymphocytes, B lymphocytes, monocytes, fibroblasts, and endothelial cells. Anti-mouse IL-6-InVivo has been shown to neutralize the bioactivity of natural or recombinant IL-6.
A2108 Anti-mouse CD28-InVivo in vitro T cell stimulation/activation The PV-1 monoclonal antibody(Clone: PV-1) reacts with mouse CD28.The PV-1 antibody has been shown to stimulate the proliferation and cytokine production by activated T and NK cells.
A2119 Rat IgG1 isotype control-InVivo Rat IgG1 isotype control-InVivo monoclonal antibody (Clone:HRPN) reacts with horseradish peroxidase (HRP). Because HRP is not expressed by mammals this antibody is ideal for use as an isotype-matched control for rat IgG1 antibodies in most in vivo and in vitro applications.
A2105 Anti-mouse IFNγ-InVivo in vivo/vitro IFNγ neutralization The R4-6A2 monoclonal antibody reacts with mouse IFNγ (interferon gamma) which is a 20 kDa soluble pleiotropic cytokine and the sole member of the type II class of interferons. The R4-6A2 antibody has been shown to neutralize both natural and recombinant IFNγ.
A2109 Anti-mouse IL-4-InVivo in vivo/vitro IL-4 neutralization,FCM,WB The 11B11 monoclonal antibody reacts with mouse IL-4 (interleukin-4) which is a multifunctional 14 kDa cytokine.The 11B11 monoclonal antibody has been shown to neutralize the bioactivity of natural or recombinant IL-4.
A2159New Anti-mouse CSF1R (CD115)-InVivo Anti-mouse CSF1R (CD115)-InVivo reacts with mouse colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115. CSF1R is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family.
A2141New Anti-mouse Ter-119-InVivo Anti-mouse Ter-119-InVivo Anti-mouse Ter-119-InVivo reacts with mouse Ter-119, a 52 kDa glycophorin A-associated protein that is expressed by erythroid cells from the early proerythroblast stage to mature erythrocytes. Anti-mouse Ter-119-InVivo is commonly used for identifying erythrocytes and cells in the erythroid lineage.
A2142New Anti-mouse/rat IL-1β-InVivo Anti-mouse/rat IL-1β-InVivo Anti-mouse/rat IL-1β-InVivo reacts with precursor and mature secreted forms of mouse and rat IL-1β a 17 kDa pro-inflammatory cytokine produced primarily by monocytes.
A2143New Anti-mouse 4-1BB (CD137)-InVivo Anti-mouse 4-1BB (CD137)-InVivo Anti-mouse 4-1BB (CD137)-InVivo reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137.
A2144New Anti-mouse TIGIT-InVivo Anti-mouse TIGIT-InVivo Anti-mouse TIGIT-InVivo reacts with mouse TIGIT (T cell immunoreceptor with Ig and ITIM domains). TIGIT is a 26 kDa, type I transmembrane protein and a member of the poliovirus receptor (PVR) family.
A2145New Mouse IgG2b isotype control-InVivo Mouse IgG2b isotype control-InVivo Mouse IgG2b isotype control-InVivo is ideal for use as a non-reactive isotype-matched control for mouse IgG2b antibodies in most in vivo and in vitro applications.
A2165New Anti-mouse PD-1 (CD279)(29F.1A12)-InVivo in vivo blocking of PD-1/PD-L signaling in vitro PD-1 neutralization Anti-mouse PD-1 (CD279)(29F.1A12)-InVivo reacts with mouse PD-1 (programmed death-1) also known as CD279. PD-1 is a 50-55 kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the Ig superfamily.
A2146New Anti-LCMV nucleoprotein-InVivo Anti-LCMV nucleoprotein-InVivo Anti-LCMV nucleoprotein-InVivo reacts with lymphocytic choriomeningitis virus (LCMV) nucleoprotein (NP), a 63 kDa structural protein.
A2147New Anti-mouse CXCR3 (CD183)-InVivo Anti-mouse CXCR3 (CD183)-InVivo Anti-mouse CXCR3 (CD183)-InVivo reacts with mouse CXCR3 also known as CD183, a 38 kDa chemokine receptor for CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (ITAC).
A2148New Anti-mouse GM-CSF-InVivo Anti-mouse GM-CSF-InVivo Anti-mouse GM-CSF-InVivo reacts with mouse granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2).
A2149New Anti-mouse CD19-InVivo Anti-mouse CD19-InVivo Anti-mouse CD19-InVivo reacts with mouse CD19, a B cell-specific 95 kDa transmembrane glycoprotein of the immunoglobulin superfamily.
A2150New Armenian hamster IgG isotype control-InVivo Armenian hamster IgG-InVivo Armenian hamster IgG isotype control-InVivo is ideal for use as an isotype control for Armenian hamster IgG antibodies in most in vivo and in vitro applications.
A2151New Anti-mouse IL-10R (CD210)-InVivo Anti-mouse IL-10R (CD210)-InVivo Anti-mouse IL-10R (CD210)-InVivo reacts with mouse IL-10R (IL-10 receptor) also known as CD210. The IL-10R is a class II cytokine receptor and is expressed by a variety of cell types including thymocytes, T lymphocytes, B lymphocytes, NK cells, monocytes, and macrophages.
A2152New Anti-mouse IFNγ (XMG1.2)-InVivo Anti-mouse IFNγ (XMG1.2)-InVivo Anti-mouse IFNγ (XMG1.2)-InVivo reacts with mouse IFNγ (interferon gamma) a 20 kDa soluble pleiotropic cytokine and the sole member of the type II class of interferons.
A2153New Anti-mouse IL-2 (S4B6-1)-InVivo Anti-mouse IL-2 (S4B6-1)-InVivo Anti-mouse IL-2 (S4B6-1)-InVivo reacts with mouse IL-2, a 17 kDa cytokine that is mainly produced by T cells in response to antigenic or mitogenic stimulation.
A2154New Anti-mouse CD86 (B7-2)-InVivo Anti-mouse CD86 (B7-2)-InVivo Anti-mouse CD86 (B7-2)-InVivo reacts with mouse CD86 also known as B7-2. CD86 is an 80 kDa Ig superfamily member.
A2156New Anti-human PD-L1 (B7-H1)-InVivo Anti-human PD-L1 (B7-H1)-InVivo Anti-human PD-L1 (B7-H1)-InVivo reacts with human PD-L1 (programmed death ligand 1) also known as B7-H1 or CD274. PD-L1 is a 40 kDa type I transmembrane protein that belongs to the B7 family of the Ig superfamily.
A2157New Anti-mouse IL-6R-InVivo Anti-mouse IL-6R-InVivo Anti-mouse IL-6R-InVivo reacts with the mouse IL-6 receptor α chain also known as CD126. CD126 is an 80 kDa type I cytokine receptor and a member of the immunoglobulin superfamily.
A2158New Anti-mouse Ly6G-InVivo Anti-mouse Ly6G-InVivo Anti-mouse Ly6G-InVivo reacts with mouse Ly6G. Ly6G is a 21-25 kDa member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion.
A2126 Anti-mouse VEGFR-2-InVivo Anti-mouse VEGFR-2-InVivo Anti-mouse VEGFR-2-InVivo (Clone: DC101) monoclonal antibody reacts with mouse VEGFR-2 (vascular endothelial growth factor receptor 2) also known as CD309, KDR, and Flk-1 and inhibit VEGFR-2 signaling in vivo. VEGFR-2 plays a key role in vascular development and permeability.
A2127 Anti-human CD28-InVivo Anti-human CD28-InVivo Anti-human CD28-InVivo (Clone: 9.3) monoclonal antibody reacts with human CD28, a 45 kDa costimulatory receptor and a member of the Ig superfamily. It stimulate the proliferation of human T cells in vitro.
A2129 Anti-mouse Thy1.2 (CD90.2)-InVivo Anti-mouse Thy1.2 (CD90.2)-InVivo Anti-mouse Thy1.2 (CD90.2)-InVivo(clone 30H12) is a monoclonal antibody reacts with mouse Thy1.2 also known as CD90.2. It induces Ca2+ flux in thymocytes and is particularly useful for depleting T lymphocytes.
A2130 Anti-mouse LFA-1α (CD11a)-InVivo Anti-mouse LFA-1α (CD11a)-InVivo Anti-mouse LFA-1α (CD11a)-InVivo(clone M17/4) is a monoclonal antibody reacts with mouse LFA-1α (lymphocyte function-associated antigen 1 alpha) also known as integrin alpha L chain and CD11a. It plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50), and also functions in lymphocyte costimulatory signaling.
A2131 Anti-mouse TIM-3 (CD366)-InVivo Anti-mouse TIM-3 (CD366)-InVivo Anti-mouse TIM-3 (CD366)-InVivo monoclonal antibody reacts with mouse TIM-3 (T cell immunoglobulin and mucin domain-3) also known as CD366. TIM-3 is specifically expressed at high levels on the surface of Th1 lymphocytes. This B8.2C12 antibody binds to the BALB/c allele of TIM-3 while reactivity to the C57Bl/6 allele. Inhibition of TIM-3 signaling in mice exacerbates experimental autoimmune encephalomyelitis and promotes IFNγ production and Th1 cell proliferation.
A2132 Anti-mouse/human/rat CCL2 (MCP-1)-InVivo in vivo CCL2 neutralization, Immunohistochemistry (frozen) Anti-mouse/human/rat CCL2 (MCP-1)-InVivo (Clone: 2H5) antibody reacts with mouse, human, and rat CCL2, also known as monocyte chemoattractant protein 1 (MCP-1). MCP-1 is a 13 kDa chemokine produced mainly by monocytes/macrophages and is a potent monocyte-attracting chemokine. The 2H5 antibody has been shown to neutralize the biological effects of CCL2 in vivo.
A2133 Anti-mouse LAG-3-InVivo in vitro &in vivo LAG-3 neutralization, Flow cytometry, Western blot Anti-mouse LAG-3-InVivo (Clone: C9B7W) monoclonal antibody reacts with mouse LAG-3 also known as CD223. LAG-3 promotes immune responses by activating antigen-presenting cells. The C9B7W antibody has been reported to block the function of murine LAG-3 in vivo and in vitro.
A2134 Anti-mouse IL-18-InVivo in vitro &in vivo IL-18 neutralization Anti-mouse IL-18-InVivo (Clone:YIGIF74-1G7) monoclonal antibody reacts with mouse IL-18. IL-18 an 18 kDa pro-inflammatory cytokine is expressed by activated macrophages, keratinocytes, Kupffer cells, intestinal epithelial cells, and osteoblasts.
A2160New Anti-rat Kappa Immunoglobulin Light Chain-InVivo Anti-rat Kappa Immunoglobulin Light Chain-InVivo Anti-rat Kappa Immunoglobulin Light Chain-InVivo reacts with the kappa chain of the rat immunoglobulin light chain. The κ chain is one of two types of polypeptide subunits which make up the immunoglobulin light chain.
A2161New Anti-mouse ICOSL (CD275)-InVivo Anti-mouse ICOSL (CD275)-InVivo Anti-mouse ICOSL (CD275)-InVivo reacts with mouse ICOSL (inducible T cell co-stimulator ligand) also known as CD275, B7RP-1, and B7-H2. ICOSL is a 40 kDa immune checkpoint protein belonging to the Ig receptor superfamily.
A2162New Anti-mouse/human VLA-4 (CD49d)-InVivo Anti-mouse/human VLA-4 (CD49d)-InVivo Anti-mouse/human VLA-4 (CD49d)-InVivo reacts with human and mouse VLA-4 α chain also known as CD49d and integrin alpha 4. VLA-4 is a 150 kDa glycoprotein belonging to the integrin family that is expressed by many cell types including T and B lymphocytes, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, and dendritic cells.
A2166New Anti-mouse CD28(37.51)-InVivo Anti-mouse CD28(37.51)-InVivo Anti-mouse CD28(37.51)-InVivo reacts with mouse CD28, a 45 kDa costimulatory receptor and a member of the Ig superfamily. CD28 is expressed by thymocytes, most peripheral T cells, and NK cells.
A2106 Mouse IgG1 isotype control-InVivo FCM,IHC,IP,WB The monoclonal mouse IgG1 K immunoglobulin is ideal for use as a non-reactive isotype-matched control for mouse IgG1 antibodies in most in vivo and in vitro applications.
A2123 Rat IgG2a isotype control-InVivo Rat IgG2a isotype control-InVivo can be used as an isotype-matched control for rat IgG2a antibodies.
A2112 Anti-mouse CD40L (CD154)-InVivo in vivo/vitro blocking of CD40/CD40L,WB The MR-1 monoclonal antibody reacts with mouse CD154 also known as CD40 ligand. The MR-1 monoclonal antibody has been reported to inhibit in vitro activation of B lymphocytes by blocking the binding of CD154 with CD40 on T helper cells as well as inhibit the formation of germinal centers and disrupt antigen-specific T cell responses. Additionally, the MR-1 antibody blocks interactions of T cells and antigen-presenting cells in vitro and blocks the development of experimental autoimmune disease in vivo.
A2167New Anti-mouse CD3-InVivo Anti-mouse CD3-InVivo Anti-mouse CD3-InVivo reacts with mouse CD3, a transmembrane cell-surface protein that belongs to the immunoglobulin superfamily.CD3 is expressed on T lymphocytes, NK-T cells, and to varying degrees on developing thymocytes.
A2163New Anti-mouse IL-12 p40-InVivo Anti-mouse IL-12 p40-InVivo Anti-mouse IL-12 p40-InVivo reacts with mouse p40 also known as IL-12β. p40 is a 40 kDa subunit of IL-12 and IL-23. IL-12 is a heterodimeric cytokine composed of subunits IL-12α p35 and IL-12β p40.
A2164New Anti-mouse B220-InVivo Anti-mouse B220-InVivo Anti-mouse B220-InVivo reacts with mouse B220 also known as CD45R. B220 is a 220 kDa transmembrane protein tyrosine phosphatase expressed on B cells and some subsets of T and NK cells.
A2124 Anti-mouse TNFα-InVivo in vitro &in vivo TNFα neutralization, Western blot Anti-mouse TNFα-InVivo reacts with mouse TNFα (tumor necrosis factor-alpha), a multifunctional proinflammatory cytokine. TNFα dysregulation is been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. TNFα knockout animals display defects in response to bacterial infection, characterized by defects in forming organized follicular dendritic cell networks and germinal centers with a lack of primary B cell follicles.
A2125 Anti-mouse OX40 (CD134)-InVivo in vitro &in vivo OX40 activation, Western blot Anti-mouse OX40 (CD134)-InVivo (Clone: OX-86) monoclonal antibody reacts with mouse OX-40 also known as CD134. OX-40 plays a major role in regulating both CD4 and CD8 T cell clonal expansion. Anti-mouse OX40 (CD134)-InVivo treatment strongly enhances the generation of antigen-specific effector T cells, prevents the induction of T cell tolerance, and delays tumor growth in vivo.
A2136New Anti-mouse CD40-InVivo Anti-mouse CD40-InVivo Anti-mouse CD40-InVivo reacts with mouse CD40 also known as Bp50. CD40 is a type I transmembrane glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily.
A2137New Anti-mouse CD8β (Lyt 3.2)-InVivo Anti-mouse CD8β (Lyt 3.2)-InVivo Anti-mouse CD8β (Lyt 3.2)-InVivo reacts with mouse CD8β also known as Lyt 3.2. The CD8 antigen is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR).
A2138New Anti-mouse IL-2-InVivo Anti-mouse IL-2-InVivo Anti-mouse IL-2-InVivo reacts with mouse IL-2, a cytokine that is mainly produced by T cells in response to antigenic or mitogenic stimulation
A2140New Anti-mouse/human/rat CD47 (IAP)-InVivo Anti-mouse/human/rat CD47 (IAP)-InVivo Anti-mouse/human/rat CD47 (IAP)-InVivo reacts with mouse CD47 otherwise known as integrin-associated protein (IAP). CD47 is an approximately 50 kDa glycosylated five transmembrane protein that is ubiquitously expressed by both hematopoietic cells such as T and B lymphocytes, monocytes, platelets and erythrocytes and non-hematopoietic cells.