Anti-mouse CD3ε-InVivo Immunology & Inflammation related inhibitor

The 145-2C11 monoclonal antibody reacts with mouse CD3ε which is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. The 145-2C11 antibody has been shown to induce T lymphocyte activation, proliferation, and apoptosis in vitro via binding and stimulating the TCR. When used in vivo the antibody is reported to produce T cell activation, anergy, or death.

Click to purchase the isotype control of Anti-mouse CD3ε-InVivo

2 Citations

17 Nobel Prize winners have used Selleck products

Shimon Sakaguchi

Nature Communications 2025,16, Article number:1325

David Baker

Dev Cell 2023, 58(20):2163-2180.e9.

David Julius

Cell 2017, 185-198.e16

Michael Houghton

Cell Chem Biol, 2020, 27(7):780-792.e5

Charles M. Rice

Cell 2018, 172(3):423-438.e25

Quality Control

Batch: Purity: 99% Protein concentration: 6.25 mg/ml Endotoxin Level: <1EU/mg

99

Product Details

Molecular Weight	150 kDa
Clone	145-2C11
Immunogen	Mouse BM10-37 cytotoxic T cells
Isotype	Armenian Hamster IgG1
Application	in vitro T cell stimulation/activation, IF, FCM, WB
Purification	protein A
Sterility	0.2 μM filtered
Formulation	PBS buffer, pH 7.0
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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