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Immunology & Inflammation related
Immunology & Inflammation related Products
- All (483)
- Immunology & Inflammation related Inhibitors (110)
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- New Immunology & Inflammation related Products
| Catalog No. | Product Name | Information | Product Use Citations | Product Validations |
|---|---|---|---|---|
| S2286 | Cyclosporin A | Cyclosporin A, a non-polar cyclic oligopeptide, is an immunosuppressive agent that binds to cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay. Cyclosporin A is generally given following transplant surgery to prevent rejection and has been used to test its toxic effect on a perfused 3D proximal tubule model. |
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| S8141 | Cl-amidine | Cl-amidine is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively. Cl-amidine induces apoptosis. | ||
| S7434 | TAPI-1 | TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP). |
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| S3032 | Bindarit | Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8. |
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| S4169 | Teriflunomide | Teriflunomide (A77 1726, HMR-1726) is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent. |
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| S1576 | Sulfasalazine | Sulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. Sulfasalazine is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. Sulfasalazine induces ferroptosis, apoptosis and autophagy. | ||
| S1737 | Prednisolone | Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. |
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| A2001 | Ipilimumab (anti-CTLA-4) | Ipilimumab (anti-CTLA-4) is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. MW : 148 kD. |
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| S5004 | Pimecrolimus | Pimecrolimus (Elidel,ASM 981,SDZ-ASM 981) is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12 (FKBP-12); a calcineurin inhibitor. |
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| S2910 | Tempol | Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2. | ||
| S1439 | Tranilast | Tranilast is an antiallergic drug by inhibiting lipid mediator and cytokine release from inflammatory cells, used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. |
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| S3648 | Amlexanox | Amlexanox is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε. | ||
| A2102 | Anti-mouse CD8α-InVivo | Anti-mouse CD8α (Clone:2.43)reacts with mouse CD8α. CD8 is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). It binds to class I MHC molecules displayed by antigen presenting cells (APC). |
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| S2359 | Sinomenine | Sinomenine (Cucoline, Kukoline), a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis. |
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| S1514 | Cyclosporine | Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. | ||
| A2009 | Rituximab (anti-CD20) | Rituximab (anti-CD20) is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM, MW: 143.86 KD. | ||
| S8301 | Ossirene (AS101) | Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme. | ||
| S5804 | N-Acetylcysteine amide | N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. | ||
| S2413 | Geniposidic acid | Geniposidic acid is an iridoid glucoside, used to treat inflammation, jaundice and hepatic disorders. | ||
| S1654 | Phenylbutazone | Phenylbutazone (Butazolidine) is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis. | ||
| S8660 | GI254023X | GI254023X (GI 4023, SRI028594) is a selective inhibitor of ADAM10 with 100-fold selectivity for ADAM10 over ADAM17. The IC50 values for recombinant ADAM10 amd ADAM17 are 5.3 nM and 541 nM, respectively.GI254023X can inhibit MMP9. | ||
| S2350 | Rutin | Rutin (Rutoside), a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human. | ||
| S1591 | Bestatin (Ubenimex) | Bestatin (Ubenimex) is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia. |
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| S1622 | Prednisone | Prednisone is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound. | ||
| S5501 | Hydrocortisone acetate | Hydrocortisone Acetate (Cortisol 21-acetate) is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties. | ||
| S8760 | Iberdomide (CC220) | Iberdomide (CC-220) is a novel oral immunomodulatory compound that targets cereblon, part of the CRL4CRBN E3 ubiquitin ligase complex, with an IC50 of 60 nM in a competitive TR-FRET assay. Iberdomide (CC-220) induces apoptosis with antitumor and immunostimulatory activities. | ||
| S7448 | CORM-3 | CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity. | ||
| S1211 | Imiquimod | Imiquimod is a novel synthetic agent with immune response modifying activity. | ||
| S5260 | ATP | ATP (Adenosine-Triphosphate, Adenosine 5'-triphosphate) is a multifunctional nucleoside triphosphate and an important endogenous signaling molecule in immunity and inflammation. | ||
| S5318 | Acacetin | Acacetin (Linarigenin, 5,7-dihydroxy-4'-methoxyflavone, 4'-Methoxyapigenin) is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects. | ||
| S9311 | Germacrone | Germacrone, a major activity component found in Curcuma zedoaria oil product, shows anti-inflammatory, antiandrogenic, and antimicrobial activities. | ||
| S2338 | Oxymatrine | Oxymatrine (Matrine N-oxide) is a quinolizidine alkaloid extracted from the root of Sophora flavescens with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. It is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases. | ||
| S2383 | Gastrodin | Gastrodin (Gastrodine), an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases. | ||
| S7892 | Avadomide (CC-122) | Avadomide (CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN. | ||
| S8291 | Atractylenolide I | Atractylenolide I is the major sesquiterpenoid of the rhizome of A. macrocephala and shows a wide spectrum of pharmacological activities such as antiinflammatory, digestion promoting, and antioxidant effects. | ||
| S7516 | Y-320 | Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM. | ||
| S1733 | Methylprednisolone | Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. |
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| S5500 | Amodiaquine hydrochloride | Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. | ||
| S3758 | Sinomenine hydrochloride | Sinomenine (SN, Cucoline, Kukoline, Sabianine A), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent. | ||
| S9430 | Tomatidine Hydrochloride | Tomatidine Hydrochloride, a natural steroidal alkaloid, possesses potent antibacterial activity and has anti-inflammatory effects in macrophages. | ||
| S4761 | Thymoquinone | Thymoquinone (TQ) is the bioactive phytochemical constituent of the seeds oil of Nigella sativa with anti-inflammatory and anti-oxidant effects. | ||
| S2787 | Laquinimod | Laquinimod (ABR-215062, LAQ) is a potent immunomodulator. Phase 3. | ||
| S1681 | Mesalazine (5-ASA) | Mesalazine (5-ASA) is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease. | ||
| S3608 | Demethylzeylasteral (T-96) | Demethylzeylasteral (T-96), the active component isolated from Tripterygium wilfordii Hook F., inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects. | ||
| S3614 | Lupeol | Lupeol (Clerodol, Monogynol B, Fagarasterol, Farganasterol) is a significant lupane-type triterpene represented in the plant, fungi and animal kingdoms with anticancer, antiprotozoal, chemopreventive and anti-inflammatory properties. | ||
| S4268 | Flufenamic acid | Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator. | ||
| S3824 | Quercitrin | Quercitrin (3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities. | ||
| S5648 | Iguratimod | Iguratimod (T-614) is a small molecule compound with anti-inflammatory and immunomodulatory actions and used for the treatment of rheumatoid arthritis. | ||
| S9038 | Calycosin | Calycosin (3'-Hydroxyformononetin), an isoflavonoid, is the major active component in Radix Astragali. It shows antitumor, anti-inflammatory, neuroprotective and pro-angiogenesis effects. | ||
| S9032 | Sanguinarine | Sanguinarine (Pseudochelerythrine, Sanguinarin, Sanguinarium), a benzophenanthridine alkaloid known as an anti-inflammatory agent, is a potent inhibitor of NF-κB activation. | ||
| S8097 | C-DIM12 | C-DIM12 is a Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells. | ||
| S9131 | Punicalagin | Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects., Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects. | ||
| S6812 | Z-Guggulsterone | Z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Z-Guggulsterone exhibits anti-inflammatory effects in microglia. Z-Guggulsterone induces apoptosis in gastric cancer cells through the intrinsic mitochondria-dependent pathway. | ||
| S5517 | Fenamic acid | Fenamic acid (N-Phenylanthranilic acid, 2-(Phenylamino)benzoic acid, 2-Anilinobenzoic acid, Diphenylamine-2-carboxylic acid) serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid. | ||
| A2028 | Tiragolumab (anti-TIGIT) | Tiragolumab (anti-TIGIT) (RG6058, MTIG7192A) is a humanized IgG1/kappa monoclonal antibody that binds TIGIT to prevent its interaction with its ligand PVR (CD155). | ||
| S1829 | Pranlukast | Pranlukast (ONO-1078,ono-rs-411) is an orally administered, and selective antagonist of the cysteinyl leukotrienes (LT) C(4), LTD(4) and LTE(4), used in the prophylactic treatment of chronic bronchial asthma. | ||
| S3062 | Diclofenac Potassium | Diclofenac potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. | ||
| S7515 | VGX-1027 | VGX-1027 (GIT 27) is an orally active immunomodulator. Phase 1. | ||
| S1823 | Fenoprofen Calcium | Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent. | ||
| S2411 | Geniposide | Geniposide is an iridoid glycoside isolated from the fruit of Gardenia jasminoides Ellis. | ||
| S5737 | Diclofenac Epolamine | Diclofenac Epolamine (DHEP, DIEP, diclofenac hydroxyethylpyrrolidine) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. | ||
| S5157 | Thymol | Thymol (2-isopropyl-5-methylphenol, IPMP), a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro. | ||
| S5674 | Lodoxamide Tromethamine | Lodoxamide Tromethamine (Alomide, Lodoxamidetromethamine) is the tromethamide salt form of lodoxamide, a synthetic mast cell stabilizing compound with anti-inflammatory activity. | ||
| S9213 | Jujuboside A | Jujuboside A, isolated from Semen Ziziphi Spinosae, exerts anti-oxidant, anti-inflammatory activities, and reduces the cell apoptosis. | ||
| S6239 | PMX-53 | PMX-53 is a potent CD88 (C5aR) antagonist and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2). | ||
| S9043 | 6-Shogaol | 6-Shogaol, a naturally occuring product found in ginger, has anti-inflammatory and anticancer properties., | ||
| S9247 | Isoliensinine | Isoliensinine is an alkaloid produced by the edible plant Nelumbo nucifera. It possesses anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities. | ||
| S5661 | Tiaprofenic acid | Tiaprofenic acid (Tiaprofensaeure, Acido tiaprofenico) is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain. | ||
| S2387 | Lappaconite HBr | Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects. | ||
| S6185 | Arachidonic acid | Arachidonic acid (Arachidonate) is an unsaturated, essential fatty acid found in animal and human fat as well as in the liver, brain, and glandular organs. It is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes., | ||
| S9289 | Astragalin | Astragalin (kaempferol-3-glucoside, Kaempferol 3-O-glucoside, Kaempferol 3-D-glucoside), a flavonoid from leaves of persimmon and green tea seeds, has anti-tumor, anti-inflammatory and anti-oxidant activities. | ||
| S9290 | Linarin | Linarin (Acaciin, Buddleoside, Acacetin-7-O-rutinoside), a natural flavonoid cpompound, has pharmacological effects, including anti-inflammatory, neuro-protective, cardioprotective and antioxidative effects. | ||
| S9293 | Isoliquiritin | Isoliquiritin (Neoisoliquritin) is a flavonoid glycoside compound from licorice possessing a broad spectrum of pharmacological activities including antioxidant, anti-inflammatory, and anti-depression activities. | ||
| S4170 | Coumarin | Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties. | ||
| S9304 | Platycodin D | Platycodin D, the main saponin isolated from Chinese herb Platycodonis Radix, exhibits anti-inflammatory, anti-allergic, cholesterol-lowering and neuroprotective properties. | ||
| S2400 | Rheic Acid | Rhein (Monorhein, NSC 38629, Rheinic) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Rhein is an FTO (mRNA N6-methyladenine demethylase) inhibitor and also inhibits AlkB repair enzymes. | ||
| S6322 | Pipecolic acid | Pipecolic acid (piperidine-2-carboxylic acid), a metabolite of lysine found in human physiological fluids such as urine, plasma and CSF, is an important regulator of immunity in plants and humans alike. | ||
| S3675 | Umbelliferone | Umbelliferone (7-hydroxycoumarin, hydrangine, skimmetine, beta-umbelliferone) is a 7-hydroxycoumarin that is a pharmacologically active agent. It is a fluorescing compound used as a sunscreen agent and shows good inhibitions of DPPH, hydroxyl, superoxide anion and ABTS radicals with anti-inflammatory, anti-hyperglycaemic, molluscicidal and anti-tumor activities. | ||
| S3668 | Thymopentin | Thymopentin (TP5) has immuno-regulatory activities. The immuno-regulatory actions of thymopentin on peripheral T cells are mediated by intracellular cyclic GMP elevations in contrast to the intracellular cyclic AMP elevations induced in precursor T cells that trigger their further differentiation to T cells. | ||
| S9055 | Salvianolic acid A | Salvianolic acid A (Dan Phenolic Acid A), a water-soluble compound extracted from Radix Salvia miltiorrhiza (Danshen), is an antioxidant and free radical scavenging compound that also acts as an inhibitor of the protein-protein interaction mediated by SH2 domains of Src-family kinases Src and Lck. | ||
| S9052 | Auraptene | Auraptene (7-geranyloxycoumarin) is a natural coumarin derived from citrus plants and possesses valuable pharmacological properties, including anticarcinogenic, anti-inflammatory, antihelicobacter, antigenotoxic, and neuroprotective effects. Auraptene inhibits matrix metalloproteinase 2 (MMP-2) as well as key inflammatory mediators, including IL-6, IL-8 and chemokine (C-C motif) ligand-5(CCL5). | ||
| S9057 | Sinigrin | Sinigrin (Allylglucosinolate, 2-Propenylglucosinolate) is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects. | ||
| S3027 | Fenoprofen calcium hydrate | Fenoprofen calcium hydrate(Fenoprofen calcium salt dihydrate,Feprona dihydrate,Progesic dihydrate) is a non-steroidal anti-inflammatory drug (NSAID). | ||
| S9035 | Isovitexin | Isovitexin (saponaretin, Apigenin-6-C-glucoside), an active component of many traditional Chinese medicines, has various activities, such as anti-oxidant, anti-inflammatory, anti-alzheimer disease (AD) effects and so on. | ||
| S3871 | Muscone | Muscone (3-Methylcyclopentadecanone, Methylexaltone), a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent. Muscone significantly downregulats the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in BMDMs. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6). | ||
| S9074 | Buddlejasaponin IVb | Buddlejasaponin IVb (Saikosaponin 1b), a major component of Pleurospermum kamtschaticum, exerts anti-inflammatory and cytotoxic effects against cancer cells. | ||
| S3877 | Lysionotin | Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities. | ||
| S9411 | Liensinine | Liensinine, an important functional compound in lotus seeds, has anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities. | ||
| S9105 | Ginsenoside CK | Ginsenoside CK is a ginsenoside found in Panax species and has a role as a plant metabolite, an antineoplastic agent, a hepatoprotective agent, an anti-allergic agent and an anti-inflammatory agent. | ||
| S5083 | Lentinan | Lentinan (A823605, Bromoduline), isolated and purified from a hot water extract of Lentinula edodes fruit bodies, is a fungal polysaccharide immunomodulator with anti-tumor effects. | ||
| S9115 | Wogonoside | Wogonoside (Oroxindin, Wogonin 7-O-glucuronide, Glychionide B), the main flavonoid component derived from the root of Scutellaria baicalensis Georgi, displays anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities. | ||
| S3813 | Bakuchiol | Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities., Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities. | ||
| S3745 | Balsalazide disodium | Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide Disodium suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway. | ||
| S9127 | Carnosol | Carnosol is a naturally occurring phenolic diterpene found in rosemary. It has anti-oxidant, anti-inflammatory and anti-cancer activities. | ||
| S9502 | Madecassic acid | Madecassic acid (Brahmic acid), a natural triterpene first isolated from C. asiatica, has diverse anti-inflammatory and anti-diabetic effects, blocking NF-κB activation in macrophages and causing by iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 inhibition. | ||
| S9474 | Acetylharpagide | Acetylharpagide is a monomeric compound extracted from Ajuga decumbens, widely used for remedying infectious and inflammatory diseases. | ||
| S9146 | Anwuligan | Anwuligan (Macelignan), a natural compound isolated from Myristica fragrans Houtt, has antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species. It also shows antioxidant, free radical scavenging, and neuroprotective activities. | ||
| E0206 | Ginkgetin | Ginkgetin is a biflavone from Ginkgo biloba leaves with anti-cancer, anti-inflammatory, anti-microbial, anti-adipogenic, and neuroprotective activities. |
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| S6476 | Eicosapentaenoic Acid (EPA) | Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid with antiinflammatory properties, and is present in fish and fish oils, including salmon, cod, and krill oils. | ||
| S5686 | Tryptanthrin | Tryptanthrin is a natural alkaloidal compound having basic indoloquinazoline moiety. It has broad spectrum of biological activities including anticancer activity, anti-inflammatory, antiprotozoal, antiallergic, antioxidant, and antimicrobial. | ||
| S5869 | Cortisone | Cortisone is a pregnane steroid hormone and one of main substance released by the body as a reaction to stress. It suppresses the immune system, thus reducing inflammation and attendant pain and swelling at the site of the injury. | ||
| S1939 | Levamisole hydrochloride | Levamisole, also known as (-)-Tetramisole, is an inhibitor of alkaline phosphatase, used as an anthelmintic. | ||
| S1679 | Flurbiprofen | Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs). | ||
| S2512 | Tenoxicam | Tenoxicam(Ro-12-0068) is a good HO. radicals scavenger with an IC50 of 56.7 μM. | ||
| S4098 | Halcinonide | Halcinonide(SQ-18566) is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent. | ||
| E0212 | Cornuside | Cornuside is a bisiridoid glucoside compound isolated from the fruit of Cornus officinalis SIEB. et ZUCC. Cornuside suppresses lipopolysaccharide-induced inflammatory mediators by inhibiting NF-κB activation in RAW 264.7 macrophages. Cornuside attenuates apoptosis in rat cortical neurons. |
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| S5459 | Aucubin | Aucubin (Rhinanthin), an iridoid glycoside existing in medicinal plants, has been reported to show an anti-inflammatory activity by suppression of TNF-α production in murine macrophages. | ||
| S3622 | Diammonium Glycyrrhizinate | Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1. | ||
| S5457 | Curculigoside | Curculigoside (Curculigoside A), a diterpenoid triepoxide, is one of the main bioactive phenolic compounds isolated from the rhizome of Curculigo orchioides Gaertn. and has potent antioxidant, anti-osteoporotic, immunomodulatory, and neuroprotective effects. | ||
| E0215 | Isorhapontigenin | Isorhapontigenin (ISOR), isolated from Belamcanda chinensis, is a derivative of stilbene. Isorhapontigenin possessed potent antioxidative activity. Isorhapontigenin suppresses interleukin-1β-induced inflammation and cartilage matrix damage in rat chondrocytes. |
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| E3524 | Oregano Extract | Oregano Extract is extracted from Origanum vulgare, which has benefits for cardiovascular protection, cancer prevention, and lowers gastrointestinal inflammation. | ||
| S3982 | Batyl alcohol | Batyl alcohol (Batilol, Stearyl monoglyceride, 1-O-Octadecylglycerol, Batilolum), isolated from shark liver oil, is also present in yellow bone marrow of animals and has been described as an inflammatory agent. | ||
| S5471 | Monotropein | Monotropein, an iridoids glycoside isolated from the roots of Morinda officinalis How, has been demonstrated to exhibit anti-inflammatory activity. | ||
| S5361 | Bendazac | Bendazac (bendazolic acid, AF-983) is a non-steroidal anti-inflammatory drug that delays the cataractogenic process. It may act by preventing protein denaturation. | ||
| E0150 | Carrageenan | Carrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. Carrageenan shows anticoagulant activity, antithrombotic activity, antiviral activity, anti-tumour activity and immunomodulatory activity. |
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| E0216 | Hinokiflavone | Hinokiflavone, isolated from Selaginella P. Beauv, Juniperus phoenicea and Rhus succedanea, possesses excellent pharmacological activities, including anti-inflammatory, antioxidant and antitumor activity. Hinokiflavone induces apoptosis and inhibits migration of breast cancer cells via EMT signalling pathway. |
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| S5871 | Trans-Tranilast | Trans-Tranilast is an antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis. | ||
| S4842 | Balsalazide | Balsalazide (Colazal, Giazo), an aminosalicylate and oral prodrug, is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway. | ||
| S5458 | Verbascoside | Verbascoside (Acteoside, Kusaginin), a phenylpropanoid glycoside from lemon verbena, has several biological properties such as anti-inflammatory, antimicrobial, antitumor, and antioxidant. | ||
| E3816 | Emilia Sonchifolia Extract | Emilia Sonchifolia Extract is extracted from Emilia sonchifolia, which is a potent immune response modulator. | ||
| E3527 | Glossy privet fruit Extract | Glossy Privet Fruit Extract is extracted from the fruits of Ligustrum lucidum, which has immunomodulatory effects. | ||
| S3997 | Oxaceprol | Oxaceprol (N-acetyl-L-hydroxyproline) is an anti-inflammatory drug used in the treatment of osteoarthritis. | ||
| E3818 | Solidago Decurrens Extract | Solidago Decurrens Extract is extracted from Solidago decurrens, which is used medicinally for promoting hemostasis and treating a variety of conditions, including snakebites, carbuncles, and furuncles. | ||
| S6249 | Picolinic acid (PCL 016) | Picolinic acid (PCL 016) is a pyridine carboxylate metabolite of tryptophan and acts as an anti-infective and immunomodulator. It acts by binding with the zinc associated with zinc finger proteins to alter their structure and inhibit function. | ||
| E3530 | Boat-fruited sterculia seed Extract | Boat-Fruited Sterculia Seed Extract is extracted from the seeds of boat-fruited sterculia, which has an inhibitive effect on acute inflammation. | ||
| E3821 | Alpinia Oxyphyllae Extract | Alpinia Oxyphyllae Extract is extracted from Alpinia oxyphyllae, which has potent activities in modulating multiple signaling pathways associated with β-amyloid deposition, tau protein phosphorylation, chronic inflammation, oxidative stress. | ||
| A2036 | Magrolimab (anti-CD47) | Magrolimab (anti-CD47) (5F9, GS-4721,Hu5F9 G4,ONO 7913) is a first-in-class macrophage immune checkpoint inhibitor that mainly binds to N-terminal pyroglutamate of CD47. |
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| E3824 | Scepteridium Ternatum Extract | Scepteridium Ternatum Extract is extracted from Scepteridium ternatum, which is used for the treatment of asthma. | ||
| S5322 | Sodium gualenate | Sodium gualenate (Guaiazulenesulfonate sodium), a hydrophilic derivative of guaiazulene (GA), is an unstable compound, which is gradually decomposed in the solid state at room temperature. It has anti-inflammatory and wound-healing effects. | ||
| S9203 | Notopterol | Notopterol is a kind of furanocoumarin that possesses anti-inflammatory, analgesic, and anticancer activities. | ||
| A2037 | Sabatolimab (anti-TIM-3) | Sabatolimab (anti-TIM-3) (MBG453, NVP-MBG453) is a high-affinity, humanized IgG4 antibody targeting TIM-3 on the surface of T-cells. |
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| S9204 | Oroxylin A | Oroxylin A (6-Methoxybaicalein) is a flavonoid isolated from Scutellaria root that exhibits multiple pharmacological activities, including anti-oxidative, anti-inflammatory, anti-viral and anti-tumor properties. | ||
| E3139 | Angelica Sinensis Extract | Angelica Sinensis Extract is extracted from the dried root of Angelica Sinensis (Radix Angelica Sinensis), of which the effects on cerebral infarction are through multiple pathways, including anti-arthrosclerosis, improving microcirculation, anti-platelet aggregation, anti-inflammatory and anti-oxidative effects. | ||
| S0920 | Ginkgolide J | Ginkgolide J is a minor constituent of terpene trilactone mixture of Ginkgo biloba leaves extract that inhibits GlyR-operated channels with IC50 of 2.0 μM. Ginkgolide J also inhibits cell death of rodent hippocampal neurons caused by Aβ1–42. Ginkgolide J exhibits anti‑inflammatory activity. | ||
| E3829 | Epimedium Brevicornu Extract | Epimedium Brevicornu Extract is extracted from Epimedium brevicornu Maxim, which has anti-inflammatory effects. | ||
| E3540 | Grapefruit Extract | Grapefruit Extract is extracted from Citrus paradisi Macf., which can serve as immune modulators in the intestine and maintain intestinal macrophage homeostasis. | ||
| E3834 | Jasminum Nudiflorum Extract | Jasminum Nudiflorum Extract is extracted from Jasminum nudiflorum, which helps in treating dermatosis, coryza, nasal haemorrhage, infections, and wounds. | ||
| E3839 | Houttuynia Cordata Extract | Houttuynia Cordata Extract is extracted from Houttuynia cordata, which ameliorates bladder damage and improves bladder symptoms via anti-inflammatory effects. | ||
| S9216 | Esculentoside A | Esculentoside A, isolated from the Chinese herb phytolacca esculenta, possesses a broad inhibitory effect on a panel of pro-inflammation molecules with less toxicity. | ||
| E3840 | Ulmus Pumila Bark Extract | Ulmus Pumila Bark Extract is extracted from the bark of Ulmus pumila L., which prevents inflammatory diseases mediated by excessive production of nitric oxide. | ||
| S3956 | Tetramethylpyrazine | Tetramethylpyrazine (ligustrazine, TMP) is a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities. | ||
| S4529 | Idramantone | Idramantone (Kemantane, 5-Hydroxy-2-adamantanone) is an immune agonist. | ||
| A2397 | Clivatuzumab (Anti-MUC1) | Clivatuzumab (Anti-MUC1) is a humanized anti-mucin monoclonal antibody targeting an epitope in the MUC1 antigen expressed in most pancreatic cancers. MW: 145.5 kD. | ||
| E3069 | Spinach Extract | Spinach Extract is extracted from Spinacia oleracea, which has beneficial effects on gut microbiota and SCFAs. | ||
| E3554 | Rhizoma homalomenae Extract | Rhizoma Homalomenae Extract is extracted from Rhizoma Homalomenae, which has anti-inflammatory activity. | ||
| S9222 | Dipotassium glycyrrhizinate | Glycyrrhizinate dipotassium (Neubormitin) is a widely used anti-inflammatory agent isolated from the licorice root. | ||
| E3555 | Acmella oleracea Extract | Acmella Oleracea Extract is extracted from Acmella Oleracea, which can decrease chymase activity, oxidative stress, and inflammation. | ||
| E3846 | Semen Pruni Extract | Semen Pruni Extract is extracted from Semen pruni, which is used for oedema, dermatophytosis, hypertension, constipation, chronic tracheitis, and other conditions. | ||
| E3557 | Radix Peucedani Extract | Radix Peucedani Extract is derived from Peucedani radix (Qianhu), which has strong anti-inflammatory properties and has been an important agent for treating respiratory symptoms and diseases through the centuries. | ||
| S9033 | Incensole acetate | Incensole acetate, isolated from Boswellia Resin, is a novel anti-inflammatory compound that inhibits NF-κB activation. | ||
| E3074 | Xanthium Sibiricum Extract | Xanthium Sibiricum Extract is extracted from Xanthium Sibiricum, which has anti-inflammatory activity. | ||
| E3559 | Radix rubiae Extract | Radix Rubiae Extract is extracted from Rubia cordifolia, which has anti-tumor, anti-oxidative, anti-platelet aggregation, and anti-inflammatory effects. | ||
| E4972New | Efaproxiral | Efaproxiral(RSR13) is a synthetic allosteric modifier of haemoglobin that reduces its oxygen binding affinity, facilitating oxygen release. This increases the whole blood P50 and tissue partial pressure of oxygen (Po2), enhancing oxygen delivery to tissues and improving oxygenation in hypoxic tumors. | ||
| S9228 | Schisandrin C | Schisandrin C, a dibenzocyclooctadiene lignan isolated from the fruits of Schisandra chinensis (Turcz.) Baill, has many characteristics including anti-inflammation, anti-tumor, and anti-oxidation. | ||
| S9071 | Nootkatone | Nootkatone, a natural ingredient that occurs in grapefruit and certain other plants, has antioxidant and anti-inflammatory effects. | ||
| E3852 | Oenothera Biennis Extract | Oenothera Biennis Extract is extracted from Oenothera biennis L., which has high anti-inflammatory properties. | ||
| E3853 | Blueberry Fruit Extract | Blueberry Fruit Extract is extracted from the fruits of Vaccinium, which helps in maintenance of blood sugar levels, reduction of oxidative stress, anti-inflammatory effect, prevention of cardiovascular diseases, antimicrobial and antitumoural activity. | ||
| E3854 | Coriolus Versicolor Extract | Coriolus Versicolor Extract is extracted from Coriolus versicolor, which possesses cytotoxic activity against cancer cells and endothelial cells and has the ability to inhibit the expression of the pro-tumorigenic factors associated with inflammation. | ||
| E3564 | Celery Extract | Celery Extract is extracted from Apium graveolens, which has suppressive effect on PMA/ionomycin mediated CD4+ T lymphocyte activation. | ||
| S3969 | Veratric acid | Veratric acid (3,4-Dimethoxybenzoic acid), a simple benzoic acid derived from plants and fruits, has anti-oxidant, anti-inflammation, and blood pressure-lowering effects. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation. | ||
| E3565 | Celery seed Extract | Celery Seed Extract is extracted from the seed of Apium graveolens, which has suppressive effect on PMA/ionomycin mediated CD4+ T lymphocyte activation. | ||
| S0947 | Cafestol | Cafestol is a natural diterpenes extracted from coffee beans. Cafestol induces apoptosis and regulates a variety of inflammatory mediators to reduce inflammation. Cafestol inhibits PI3K/Akt pathway. Cafestol also can reduce the production of ROS in the leukemia cell line HL60. | ||
| E3080 | Platycladi Cacumen Extract | Platycladi Cacumen Extract is extracted from Platycladi Cacumen, which has been traditionally used to resist alopecia and promote hair growth. | ||
| S9225 | Santalol | Santalol is a naturally occuring sesquiterpene that has antibacterial, anti-hyperglycaemic, anti inflammatory and antioxidant effects. | ||
| E3567 | Ash bark Extract | Ash Bark Extract is extracted from the bark of Fraxinus chinensis, which has anti-Inflammatory effect. | ||
| E3082 | Bupleurum Extract | Bupleurum Extract is extracted from Bupleurum, which has been used in the treatment of inflammation. | ||
| S9237 | Berberrubine | Berberrubine (Beroline, 9-Berberoline), an isoquinoline alkaloid isolated from many medicinal plants, possesses diverse pharmacological activities, including glucose-lowering, lipid-lowering, anti-inflammatory, and anti-tumor effects. | ||
| E3860 | Euphorbia Helioscopia Extract | Euphorbia Helioscopia Extract is extracted from Euphorbia helioscopia L., which has been used in the treatment of various diseases, including edema, phlegm and cough, malaria, dysentery, scab, tuberculous fistula, osteomyelitis, and cancer. | ||
| E3570 | Artemisia annua Extract | Artemisia Annua Extract is extracted from Artemisia Annua, which has antimalarial and anticancer effects. | ||
| S9240 | Isofraxidin | Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent. | ||
| E2634 | H-Leu-Leu-OMe Hydrochloride | H-Leu-Leu-OMe Hydrochloride (H-LEU-LEU-OME HCL, L-Leucyl-L-Leucine methyl ester), a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential, also can induce endolysosomal pathway stress. | ||
| S9242 | Narirutin | Narirutin (Naringenin-7-O-rutinoside, Isonaringin), a flavanone abundant in citrus fruits, possesses anti-inflammatory and anti-oxidative effects. | ||
| E0365 | Fucoidan | Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc. |
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| E3188 | Cissus Quadrangularis Extract | Cissus Quadrangularis Extract is extracted from Cissus quadrangularis, which is used in the treatment of osteoporosis, asthma, haemorrhoids, and menstrual disorders. | ||
| A2859 | Nurulimab (Anti-CTLA-4 / CD152) | Nurulimab (Anti-CTLA-4 / CD152) is a monoclonal antibody directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4, CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. MW: 145.34 KD. | ||
| S9243 | Protosappanin B | Protosappanin B (FT-0689654, Q-100961), extracted from Lignum Sappan, possesses anti-inflammation and anti-oxidation properties. | ||
| A2860 | Zalifrelimab (Anti-CTLA-4 / CD152) | Zalifrelimab (Anti-CTLA-4 / CD152) is a recombinant human monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), with immune checkpoint inhibitory and antineoplastic activities. MW: 144.48 KD. | ||
| E3867 | Fritillariae Thunbergii Bulbus Extract | Fritillariae Thunbergii Bulbus Extract is extracted from Fritillariae thunbergii bulbus, which is used to treat symptoms of cough and airway congestion in the chest due to pathological colds and damp phlegm. | ||
| A2131 | Anti-mouse TIM-3 (CD366)-InVivo | Anti-mouse TIM-3 (CD366)-InVivo monoclonal antibody reacts with mouse TIM-3 (T cell immunoglobulin and mucin domain-3) also known as CD366. TIM-3 is specifically expressed at high levels on the surface of Th1 lymphocytes. This B8.2C12 antibody binds to the BALB/c allele of TIM-3 while reactivity to the C57Bl/6 allele. Inhibition of TIM-3 signaling in mice exacerbates experimental autoimmune encephalomyelitis and promotes IFNγ production and Th1 cell proliferation. | ||
| S9245 | Phellodendrine chloride | Phellodendrine chloride, isolated from the Phellodrndron amurensis, exhibits immunosuppressive and anti-inflammatory activities. | ||
| A2132 | Anti-mouse/human/rat CCL2 (MCP-1)-InVivo | Anti-mouse/human/rat CCL2 (MCP-1)-InVivo (Clone: 2H5) antibody reacts with mouse, human, and rat CCL2, also known as monocyte chemoattractant protein 1 (MCP-1). MCP-1 is a 13 kDa chemokine produced mainly by monocytes/macrophages and is a potent monocyte-attracting chemokine. The 2H5 antibody has been shown to neutralize the biological effects of CCL2 in vivo. | ||
| S9246 | Tiliroside | Tiliroside, a glycosidic flavonoid, possesses anti-inflammatory, antioxidant, anticarcinogenic and hepatoprotective activities. | ||
| E0174 | Betamethasone sodium phosphate | Betamethasone sodium phosphate (Betamethasone 21-Phosphate Disodium Salt) is a potent glucocorticoid with anti-inflammatory activity. |
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| E3870 | Gardenia Fruit Extract | Gardenia fruit Extract is extracted from the fruits of Gardenia jasminoides Ellis., a flowering plant belonging to Rubiaceae family. Gardenia fruit is used not only as a food coloring but also as a medicine to treat hepatic disorders, headache, jaundice, inflammation, and hypertension. | ||
| S9248 | Homoorientin | Homoorientin (Isoorientin, Luteolin-6-C-glucoside) is a flavone that acts as a radical scavenger and an antineoplastic agent. | ||
| S9005 | Stearyl Glycyrrhetinate | Stearyl glycyrrhetinate, the stearyl ester of 18-β-glycyrrhetinic acid, has been demonstrated to improve antiviral effects, reduce inflammation and suppress allergies in the pharmaceutical and cosmetic industry. | ||
| E3875 | Unripe Bitter Orange Extract | Unripe Bitter Orange Extract is extracted from the bitter fruit of citrus unshiu, which is an effective anti-allergic functional food. | ||
| E3099 | Fritillaria Cirrhosa Seed Extract | Fritillaria Cirrhosa Seed Extract is extracted from the seeds of Fritillaria Cirrhosa, which is famous for its antitussive, expectorant, anti-asthma and anti-inflammatory properties, and is widely used to treat respiratory diseases. | ||
| S9254 | Skimmin | Skimmin is one of the major pharmacologically active molecules present in Hydrangea paniculata, a medical herb used in the traditional Chinese medicine as an anti-inflammatory agent. | ||
| E3878 | Stalactitum Extract | Stalactitum Extract is extracted from Stalactitum, which can be used as an anti-asthmatic. | ||
| E3879 | Glabrous Sarcandra Herb Extract | Glabrous Sarcandra Herb Extract is extracted from Sarcandra glabra (Thunb.), which has been applied to treat sore throats, abscesses, and even tumors. | ||
| S8091New | 25-Hydroxycholesterol | 25-Hydroxycholesterol is a side-chain oxysterol and a selective suppressor of IgA production by B cells with an EC50≈65 nM. It affects the immune system and has a key role in the pathogenesis of atherosclerosis. | ||
| S6058 | β-Caryophyllene | β-Caryophyllene is a natural bicyclic sesquiterpene that is a constituent of many essential oils. It acts as a non-steroidal anti-inflammatory drug, a fragrance and a metabolite. | ||
| E3883 | Umbellate Pore Fungus Extract | Umbellate Pore Fungus Extract is extracted from Umbellate pore fungus, which helps in clearing dampness and promoting diuresis. | ||
| S5138 | Citral | Citral (Geranialdehyde) is an α,β-unsaturated aldehyde present in the oils of several plants. It is an aroma compound used in perfumery for its citrus effect and is also used as a flavor and for fortifying lemon oil. | ||
| S9266 | Ginsenoside Rc | Ginsenoside Rc, isolated from Panax ginseng, may exert various activities including anti-cancer, anti-inflammatory, antiobesity, and anti-diabetic effects. | ||
| E3107 | Andrographis Herba Extract | Andrographis Herba Extract is obtained from the aerial part of Andrographis paniculata (Burm. F.) Nees, has various activities including antimicrobial and antioxidant, antimalarial, antiangiogenic, anti-inflammatory, anti-diabetic, and in vitro α-glucosidase and α-amylase enzyme inhibitory activities. | ||
| E3109 | Cymbidium Extract | Cymbidium Extract is extracted from Cymbidium, which has analgesic and anti-inflammatory activities. | ||
| E3111 | Tribulus Terrestris Extract | Tribulus Terrestris Extract is extracted from Tribulus Terrestris, which has anti-inflammatory, analgesic, antispasmodic, anticancer, antibacterial, anthelmintic, larvicidal, and anticariogenic activities. | ||
| E3890 | Lithospermum Erythrorhizon Extract | Lithospermum Erythrorhizon Extract is extracted from Lithospermum erythrorhizon, which has an anti-inflammatory response in bronchial epithelial cells. | ||
| S3837 | Echinocystic acid | Echinocystic acid (EA), a natural triterpone enriched in various herbs, displays a range of pharmacological activities including anti-inflammatory and antioxidant effects. | ||
| S9272 | Koumine | Koumine, a Gelsemium alkaloid, possesses analgesic, anti-inflammatory and neurosteroid modulating activities. | ||
| E3243 | Pinus Pinaster Bark Extract | Pinus Pinaster Bark Extract is extrcated from the bark of Pinus Pinaster, which has anti-inflammatory actions. | ||
| E3892 | Viola Philphica Munda Extract | Viola Philphica Munda Extract is extracted from Viola philphica munda, which contains polysaccharide and anodyne (has pain-killing strength) and is a diuretic. | ||
| S6136 | (±)-α-Bisabolol | α-bisabolol is a small, plant-derived, oily sesquiterpene alcohol with some anti-inflammatory and even anti-microbial properties. | ||
| E3894 | Ardisia Japonica Extract | Ardisia Japonica Extract is extracted from Ardisia japonica, which is used in the treatment of coughs and to stop uterine bleeding. | ||
| S3841 | Eleutheroside B | Eleutheroside B (syringin, Syringoside, Lilacin) is a phenylpropanoid glycoside first isolated from A. senticosus and has neuroprotective, tonic, adaptogenic, and immune-modulating properties. | ||
| E0022 | Ophiopogonin D | Ophiopogonin D (OJV-VI, Deacetylophiopogonin C) is a steroidal glycoside isolated from Chinese herb Radix ophiopogonis and shows anti-tumor property. Ophiopogonin D could suppress TGF-β1-mediated metastatic behavior of MDA-MB-231 cells by regulating ITGB1/FAK/Src/AKT/β-catenin/MMP-9 signaling axis. Ophiopogonin D attenuates PM2.5-induced inflammation via suppressing the AMPK/NF-κB pathway in mouse pulmonary epithelial cells. | ||
| E0020 | Lupenone | Lupenone (Lup-20(29)-en-3-one, lupeone) is an isolated compound exhibiting anti-oxidative, anti-inflammation, and anti-diabetic activities. Lupenone can protect SH-SY5y cells against METH-induced neuronal apoptosis through the PI3K/Akt pathway. | ||
| E3247 | Hainan Nightshade Fruit Extract | Hainan Nightshade Fruit Extract is extracted from the fruit of Hainan Nightshade, which has immunity-boosting powers and pain-eliminating abilities since it reduces inflammation and swelling in the body. | ||
| S3501 | Perflubron | Perflubron (1-Bromoperfluorooctane, Perfluorooctyl bromide, Oxygent, PFOB) exhibits anti-inflammatory activity thus decreases cytokine production in human alveolar macrophages. Perflubron also attenuates oxidative damage to both biological and nonbiological systems which is independent of its anti-inflammatory properties. | ||
| E3603 | Ramulus Mori Extract | Ramulus Mori Extract is extracted from Ramulus mori (Mulberry twigs), the dry branch of Morus alba L.. Ramulus Mori is a traditional medicine widely used for diabetes treatment. The major active components of Ramulus Mori are mulberroside A, oxyresveratrol, resveratrol, 4-hydroxycinnamic acid, 7-hydroxycoumarin, and morin, and the components have been demonstrated to possess anti-cancer, anti-hypertensive, anti-diabetic, and anti-inflammatory properties. | ||
| S3500 | Pentosan Polysulfate Sodium | Pentosan Polysulfate Sodium (PPS, Elmiron) is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also exhibits anti-HIV-1 activity. | ||
| E3898 | Radix Asteris Extract | Radix Asteris Extract is extracted from the root and rhizome of Aster tataricus L. f., which has been used to treat cough and asthma. | ||
| E3899 | Echinacea Extract (flower) | Echinacea Extract (Flower) is extracted from purple coneflower, the flower of Echinacea purpurea, Echinacea angustifolia or Echinacea pallida. Purple coneflower is used as a treatment for respiratory tract infections and inflammatory conditions, including common cold, coughs, bronchitis, and inflammation of mouth and pharynx. | ||
| S9280 | Demethoxycurcumin | Demethoxycurcumin, a natural demethoxy derivative of curcumin, has anti-oxidant, anti-inflammatory, anti-cancer, and anti-angiogenesis properties. | ||
| A2637 | Anti-CD47 (CC-90002) | Anti-CD47 (CC-90002) is a humanized monoclonal antibody (mAb) targeting CD47. It can be used for the research of hematologic malignancies and solid tumors. MW :150 KD. | ||
| S9281 | Peimine | Peimine (Verticine, Wanpeinine A) is a major biologically active component of Fritillaria ussuriensis, exhibits anti-inflammatory and pain suppression properties at the cellular level. | ||
| E3254 | Terminalia Chebula Extract | Terminalia Chebula Extract is extracted from Terminalia Chebula, which has antioxidant, hepatoprotective, neuroprotective, cytotoxic, antidiabetic, and anti-inflammatory activities. | ||
| E3609 | Elaeagnus angustifolia Extract | Elaeagnus angustifolia Extract is extracted from the fruits of Elaeagnus angustifolia L.. Elaeagnus angustifolia fruit extract has acute and chronic anti-inflammatory activities. | ||
| E3610 | Amomum villosum Extract | Amomum Villosum Extract is extracted from Amomum villosum Lour., a herbaceous plant in the ginger family. Amomum villosum has been proven to be effective in treating gastrointestinal diseases. Treatment with Amomum villosum water extract significantly attenuates intestinal inflammation in inflammatory bowel disease (IBD) rats. | ||
| E3257 | Polygoni Multiflori Root Extract | Polygoni Multiflori Root Extract is extrcated from the roots of Polygoni Multiflori, which is used for treating tuberculosis that has spread to the lymph nodes, cancer, inflammation of the prostate (prostatitis), and constipation. | ||
| E1777New | RIG012 | RIG012 is a potent antagonist of Retinoic Acid Inducible Gene 1 (RIG-I), an innate immune receptor, with an IC50 of 0.71 μM in the NADH-coupled ATPase assay. It effectively blocks RIG-I-initiated signaling and inflammatory responses induced by SARS-CoV-2 RNA. | ||
| E0025 | 2-Hydroxybenzylamine | 2-Hydroxybenzylamine (2-(Aminomethyl)phenol, 2-HOBA, NSC 127870) is a naturally occurring compound found in buckwheat and is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these electrophiles. 2-HOBA reduces inflammation and plaque apoptotic cells and promotes efferocytosis and features of stable plaques. 2-HOBA has potential for use as a nutrition supplement due to its ability to protect against the damaging effects of oxidative stress. | ||
| S9287 | Genkwanin | Genkwanin (Apigenin 7-methyl ether) is one of the major non-glycosylated flavonoids in herbs. It has a variety of pharmacological effects including anti-inflammatory, anti-bacterial, antiplasmodial, radical scavenging, chemopreventive and inhibiting 17β-Hydroxysteroid dehydrogenase type 1 activities. | ||
| E3613 | Sophora tonkinensis Extract | Sophora Tonkinensis Extract is extracted from the dried root ofSophora tonkinensis Gapnep.. Sophora tonkinensis is used in the treatment of pharyngeal and laryngeal diseases. Sophora tonkinensis has hepatoprotective, immunomodulatory, and anticancer effects and produces obvious toxicity to the liver and nervous and cardiovascular systems. | ||
| S9288 | Casticin | Casticin (Vitexicarpin), as the major active substance in Lithospermum erythrorhyzon, had been reported to mediate multiple pharmacological activities such as antioxidation, antiviral, cardiovascular protection, antineoplastic and anti-inflammation. | ||
| S5973 | Methylprednisolone Acetate | Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. | ||
| E3614 | Arnica montana Extract | Arnica Montana Extract is extracted from the flowers of Arnica montana L. (Asteraceae). Arnica montana possesses anti-inflammatory, immune-modulatory, anti-sclerotic, analgesic, antifungal, antioxidant, antibacterial, and anticancer bioactivities. | ||
| E3261 | Juglandis Semen Extract | Juglandis Semen Extract is extrcetd from the Juglandis Semen, which is commenly used in Knee osteoarthritis treatment. | ||
| E3309 | Polygala Fallax Hemsl. Rhizome Extract | Polygala Fallax Hemsl. Rhizome Extract is drawed from the rhizome of Polygala Fallax Hemsl., which has effects on immune function, such as anti-stress, anti-inflammatory, blood activating, lipid regulating, and in vitro inhibition of hepatitis B virus. | ||
| E3206 | Spirodelae Herba Extract | Spirodelae Herba Extract is extracted from Spirodelae, which may be an effective therapeutic agent for the treatment of atopic dermatitis. | ||
| E3727 | Daphne genkwa Sieb.et Zucc. Extract | Daphne Genkwa Sieb.Et Zucc. Extract is derived from the dried flowers of Daphne genkwa Sieb. et Zucc. (Thymelaeaceae), which are a Chinese herbal medicine used as an abortifacient with purgative, diuretic and anti-inflammatory activities. | ||
| S6551 | Adelmidrol | Adelmidrol is an analogue of palmitoylethanolamide (PEA) with anti-inflammatory activities. | ||
| E3264 | Black Bone Rattan extract | Black Bone Rattan Extract is extracted from Gardneria angustifolia, which has the effects of dispelling rheumatism, clearing the meridians and promoting blood circulation. | ||
| E3619 | Lonicerae Flos Extract | Lonicerae Flos Extract is extracted from Lonicerae flos, the flower bud of Lonicera macranthoides Hand.-Mazz., Lonicera hypoglauca Miq., Lonicera confusa DC., or Lonicera fulvotomentosa Hsu et S. C. Cheng. Lonicerae flos is a traditional Chinese medicine used in the treatment of inflammatory and infectious diseases. Lonicerae flos extract increases survival rates of cecal ligation and puncture (CLP)-induced septic rats. | ||
| S4165 | Benzydamine HCl | Benzydamine HCl (AF864) is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity. | ||
| E3620 | Corni Fructus Extract | Corni Fructus Extract is extracted from the fruits of Fructus Corni (Cornus officinalis Sieb. et Zucc.). Fructus Corni is a traditional Chinese herbal medicine that possesses pharmacological actions against inflammation, diabetic nephropathy, tumors, oxidation and aging. | ||
| E3316 | Scutellariae rhizome Extract | Scutellariae Rhizome Extract is isolated from the rhizome of Scutellaria baicalensis, which contains baicalin as a main constituent, has long been used in China, Japan, and Korea as a traditional medicine and functional food for inflammation, fever, hepatitis, allergic disease, hypertension, etc. | ||
| S9296 | Fraxin | Fraxin (Fraxetin-8-O-glucoside), a main active component isolated from Cortex Fraxini, possesses a variety of bioactivities such as anti-inflammatory, antioxidant, analgesic, antimicrobial, antiviral, immunomodulatory, anti-hyperuricemia and diuresis. | ||
| S9297 | Kirenol | Kirenol is a biologically active substance isolated from Herba Siegesbeckiae. It has been reported to possess anti-oxidant, anti-inflammatory, anti-allergic, anti-adipogenic, and anti-arthritic activities. | ||
| E3624 | Phytolaccae Radix Extract | Phytolaccae Radix Extract is extracted from Phytolaccae Radix (the dried root of Phytolacca acinosa Roxb. or Phytolacca americana L.). Radix Phytolaccae is widely used for the treatment of inflammation-related diseases. | ||
| E3270 | Black Rice Extract | Blackberry Extract is extracted from Rubus fruticosus, which has both anti-inflammatory and pro-inflammatory properties. | ||
| E3735 | Ficus hirta Vahl Extract | Ficus Hirta Vahl Extract is derived from Ficus hirta Vahl. (Wuzhimaotao), which possesses hepatoprotective, antibacterial, and anti-inflammatory bioactivities and improves memory function of AD mice. | ||
| S9298 | Corylin | Corylin, a main compound isolated from Psoralea corylifolia L. (Fabaceae), has a variety of pharmacological effects such as antioxidant, anti-proliferation, and anti-inflammatory properties. | ||
| E3217 | Penthorum Chinense Pursh Extract | Penthorum Chinense Pursh Extract is extrcated from Penthorum Chinense Pursh, which is used in the treatment of traumatic injury, edema, and liver diseases. | ||
| S9300 | Methylprotodioscin | Methyl protodioscin, a bioactive natural compound isolated from Dioscorea collettii Makino (Dioscoreaceae), has numerous pharmacological activities, including anti-inflammation, lipid-lowering, and anticancer activities. | ||
| E3627 | Belamcandae Rhizoma Extract | Belamcandae Rhizoma Extract is extracted from dry roots of Belamcanda chinensis (L.) DC.. Belamcanda chinensis is mainly used to treat sore throat, bronchitis, and chronic tracheitis. Isoflavonoids, including irigenin, isolated from the rhizome of Belamcanda chinensis have been suggested to possess not only antioxidative and anti-inflammatory, but also antitumor activities. | ||
| S5261 | Ufenamate | Ufenamate (Butyl flufenamate, Flufenamic acid butyl ester, Fenazol) is an anthranilic acid derivative with anti-inflammatory activity. | ||
| S6243 | Ethyl pyruvate | Ethyl pyruvate (CTI-01) is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, and anti-apoptotic functions. | ||
| E3629 | Lycopodii Herba Extract | Lycopodii Herba Extract is extracted from Lycopodii Herba, the dried whole plant of Lycopodium japonicum Thunb. (Lycopodiaceae). Lycopodii Herba possesses anti-inflammation activity, antioxidative activity, and antitumor activity; and has been traditionally used for the prevention and treatment of various diseases such as rheumatoid arthritis, contusion, quadriplegia, dysmenorrhea. | ||
| S4966 | 4-Methylesculetin | 4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level. | ||
| E0760 | Neotuberostemonine | Neotuberostemonine (NTS), one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, has a significant effect on BLM-induced pulmonary fibrosis by inhibiting macrophage recruitment and M2 polarization protective effect. | ||
| E3275 | Nigella Sativa Extract (Seed) | Nigella Sativa Extract (Seed) is extrcated from the seeds of Nigella Sativa and may include antidiabetic, anticancer, immunomodulator, analgesic, antimicrobial, anti-inflammatory, and antioxidant properties. | ||
| E3822 | Coix Lacryma-Jobi Seed Extract | Coix lacryma-jobi seed Extract is extracted from Coix lacryma-jobi L.. Coix lacryma-jobi seed has anti-inflammatory activity, hypoglycemic activity, the ability to decrease the amount of lipid components in the serum and hypocholesterolemic activity. | ||
| E4868New | Olsalazine | Olsalazine is a salicylic acid-derived anti-inflammatory agent used to treat ulcerative colitis. | ||
| E3632 | Rehmanniae Radix Extract | Rehmanniae Radix Extract is extracted from Rehmannia to treat skeletal diseases in traditional Chinese medicine and is a potent anti-osteoporotic. | ||
| E3327 | Chinese Fevervine Herb Extract | Chinese Fevervine Herb Extract is extrcated from Paederia foetida, which is used in the treatment of inflammation, piles, and diarrhea. | ||
| S9013 | Paulownin | Paulownin, a furofuran lignan from Paulownia tomentosa, has anti-inflammation, analgesia, immunity, hypoglycemia properties. | ||
| E3226 | Devil's Claw Extract | Devil'S Claw Extract is extracted from Harpagophytum, which is used in a wide range of health conditions, including indigestion, fever, allergic reactions, and rheumatism. | ||
| S3780 | Secoisolariciresinol diglucoside | Secoisolariciresinol diglucoside (SDG), a plant lignan isolated from flaxseed, has strong antioxidant activity, cardioprotective effects, reduces the blood levels of low-density lipoprotein cholesterol, and reduces the risk of hormone related cancer. | ||
| E3063 | Pygeum Topengii Bark Extract | Pygeum Topengii Bark Extract is extracted from the bark of Pygeum Topengii, which helps with prostate and kidney health and general inflammation. | ||
| S9309 | Micheliolide | Micheliolide, a sesquiterpene lactone isolated from Michelia compressa and Michelia champaca, inhibits various inflammatory response and may serve as a neuroprotective agent in neuroinflammation-related neurodegenerative disorders. | ||
| S9019 | Quillaic acid | Quillaic acid is the major aglycone of the widely studied saponins of the Chilean indigenous tree Quillaja saponaria Mol and shows strong anti-inflammatory activity. | ||
| S9313 | Atractylenolide III | Atractylenolide III, a major component of Atractylodes rhizome, has anti-inflammatory and anti-angiogenesis activities. | ||
| S5969 | Dicloxacillin Sodium hydrate | Dicloxacillin Sodium hydrate (DLX, Dycill, Dynapen, Pathocil), a narrow-spectrum β-Lactam antibiotic of the penicillin class, induces drug-metabolizing CYP enzymes to a clinically relevant extent. | ||
| E3283 | Red Bean Extract | Red Bean Extract is extracted from Red Beans, which possess various functional properties, such as anti-diabetes, anti-aging, anti-inflammatory, anticancer, and hepatoprotective activities. | ||
| E3358 | Rhizoma Fagopyri Dibotryis Extract | Rhizoma Fagopyri Dibotryis Extract is extracted from Rhizoma Fagopyri Dibotryis, which is used in the treatment of acute lung injury. | ||
| S4832 | Tolmetin | Tolmetin (Tolectin) is a nonsteroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class and also exhibits analgesic and antipyretic activity. | ||
| S9022 | 20S-Ginsenoside Rg3 | 20S-Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It exihits neuromodulatory, cognition enhancing, anti-inflammatory, antioxidative, anti-angiogenic, and anticancer activities. | ||
| E3337 | Larva of a Silkworm with Batrytis Extract | Larva Of A Silkworm With Batrytis Extract is extracted from the lara of a Bombyx with batrytis, which is used in the treatment of allergic rhinitis. | ||
| S9023 | 20S-Ginsenoside Rh2 | 20S-Ginsenoside Rh2 is a ginsenoside found in Panax species and inhibits cancer development, progression, and metastasis. | ||
| E3361 | Calendula officinalis flower Extract | Calendula Officinalis Flower Extract is extracted from the flowers of Calendula Officinalis, which has wound healing properties. | ||
| S9317 | Forsythoside A | Forsythoside A, one of the main active ingredients in Forsythiae fructus, has been shown to possess anti-bacterial and immunomodulatory properties. | ||
| S9318 | (20R)-Ginsenoside Rh1 | (20R)-Ginsenoside Rh1, isolated from the root of Panax Ginseng, exhibits various pharmacological activities including vasorelaxation, antioxidation, anti-inflammation, and anticancer. | ||
| E3288 | Red Raspberry Extract | Red Raspberry Extract is extracted from Rubus idaeus, which is rich in bioactive components that plays a role in reduction oxidative stress. | ||
| E3289 | Knoxia Valerianoides Extract | Knoxia Valerianoides Extract is extracted from Knoxia Valerianoides, which along with other herbs can be used for detoxification and treating cancer and inflammatory diseases. | ||
| S4188 | Sasapyrine | Sasapyrine (Salsalate, NSC-49171) is a nonsteroidal oral anti-inflammatory agent. | ||
| E3366 | Fineleaf Schizonepeta Herb Extract | Fineleaf Schizonepeta Herb Extract is extracted from the leaves of Schizonepeta, which is used as a traditional medicine with antipyretic, anti-inflammatory, analgesic, and hemostatic effects. | ||
| S4835 | Aceclofenac | Aceclofenac (Preservex, Airtal) is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. | ||
| S3932 | Astilbin | Astilbin (Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside), a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities. | ||
| S9324 | Alnustone | Alnustone, a naturally occuring compound found in the rhizomes of Curcuma xanthorrhiza, exhibits anti-inflammatory, antihepatotoxic and antiemetic activities. | ||
| E3346 | Oriental Paperbush flower Extract | Oriental Paperbush flower Extract is extracted from the flowers of Edgeworthia chrysantha, which might serve as a potential drug for osteolytic diseases such as osteoporosis. | ||
| E3294 | Piper Nigrum Seed Extract | Piper Nigrum Seed Extract is extracted from Piper nigrum L., which has antimicrobial activity, antioxidant effects, antidiabetic activity, hypolipidemic activity, anti-inflammatory, analgesic, anticonvulsant, and neuroprotective effects. | ||
| E3374 | Exocarpium Citri Rubrum Extract | Exocarpium Citri Rubrum Extract is extrcated from Exocarpium Citri Rubrum, which protects the stomach and eliminates dampness and phlegm. | ||
| E3759 | Periploca Sepium Extract | Periploca Sepium Extract is derived from Periploca sepium, which has traditionally been used in oriental medicine for treatment of rheumatoid arthritis (RA). | ||
| S3893 | Bornyl acetate | Bornyl acetate (Isobornyl, Bornyl acetic ether, 2-Camphanol), the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, exhibits anti-inflammatory property and it is used as an analgesic. | ||
| E3351 | Abrus mollis Extract | Abrus mollis Extract is extracted from Abrus mollis, which is used as a folk beverage and soups that are good to cleanse liver toxicants and prevent liver diseases. | ||
| E3377 | Symphytum officinale Extract | Symphytum officinale Extract is extracted from Symphytum officinale, which is commonly used in folk medicine to promote wound healing, reduce inflammation and in the treatment of broken bones. | ||
| A2939 | Ligelizumab (Anti-IgE) | Ligelizumab (anti-IgE) is a humanized high-affinity monoclonal anti-IgE antibody with the potential to be used in research on chronic spontaneous urticarial. MW: 146.6 KD. | ||
| S9054 | Pectolinarin | Pectolinarin is a major compound in Cirsium setidens with anti-inflammatory activity. Pectolinarin inhibits secretion of IL-6 and IL-8, as well as the production of PGE2 and NO. Pectolinarin induces apoptosis via inactivation of the PI3K/Akt pathway. | ||
| E0119 | Iptacopan (LNP023) Hydrochloride | Iptacopan (LNP023) Hydrochloride is a first-in-class, orally administered, potent and highly selective factor B inhibitor with an IC50 of 12 nM and a Kd value of 7.9 nM. Iptacopan exhibits excellent selectivity over other proteases affording IC50s of >30 μM across a panel of 41 human proteases. | ||
| E3298 | Viscum Coloratum Extract | Viscum Coloratum Extract is extracted from Viscum Coloratum, which is used in the therapy of inflammatory diseases. | ||
| E3352 | Radix Tinosporae Extract | Radix Tinosporae Extract is extracted from Radix Tinosporae, which is a traditional Chinese medicine for the treatment of various inflammatory diseases. | ||
| E3378 | Selaginella Extract | Selaginella Extract is extracted from Selaginella, which has considerable biological properties and can be used in pain management in emerging nursing care. | ||
| A2940 | Talizumab (Anti-IgE) | Talizumab (anti-IgE) is a humanized monoclonal antibody against immunoglobulin E (IgE) with the potential to treat food allergies. MW: 146.56 KD. | ||
| S9053 | Irisflorentin | Irisflorentin derived from the roots of Belamcanda chinensis (L.) DC. is an herb which has been used for the treatment of inflammatory disorders in traditional Chinese medicine. | ||
| E3505 | Hibiscus syriacus flower Extract | Hibiscus syriacus flower Extract is extracted from the flowers of Hibiscus syriacus, which has compounds that help in skin regeneration and hydration. | ||
| S4682 | Loxoprofen | Loxoprofen (Koloxo, Loxoprofene, Loxoprofeno) is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group. | ||
| E3574 | Cyclocarya paliurus Extract | Cyclocarya Paliurus Extract is extracted from Cyclocarya Paliurus, which has anti-fibrotic activity. | ||
| E3503 | Papaya Leaf Extract | Papaya Leaf Extract is extracted from the leaves of Carica papaya, which has anticancer, anti-inflammatory, antidiabetic, and antiviral activities. | ||
| S3765 | Picroside II | Picroside II (6-Vanilloylcatalpol, Vanilloyl catalpol) is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities. | ||
| S9051 | Asperuloside | Asperuloside, an iridoid glycoside found in Herba Paederiae, is a component from traditional Chinese herbal medicine and exerts anti-inflammatory effect. | ||
| S6593 | Methylprednisolone sodium succinate | Methylprednisolone sodium succinate (U-9088, 6α-Methylprednisolone 21-hemisuccinate Sodium) is a corticosteroid medication that reduces inflammation. | ||
| E3382 | Camu Camu fruit Extract | Camu Camu fruit Extract is extracted from the fruit of Myrciaria dubia McVaugh (Myrtaceae), which helps in preventing oxidative stress and skin inflammation induced by high glucose levels. | ||
| S9037 | Tenacissoside H | Tenacissoside H, a natural compound found in M. tenacissima, exerts anti-inflammatory and anti-tumor effects. | ||
| A2103New | Anti-mouse CTLA-4 (CD152)-InVivo | Anti-mouse CTLA-4 (CD152) antibody (Clone:9H10) reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. Anti-mouse CTLA-4 (CD152) antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding. | ||
| A2104 | Anti-mouse CD3ε-InVivo | The 145-2C11 monoclonal antibody reacts with mouse CD3ε which is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. The 145-2C11 antibody has been shown to induce T lymphocyte activation, proliferation, and apoptosis in vitro via binding and stimulating the TCR. When used in vivo the antibody is reported to produce T cell activation, anergy, or death. | ||
| E2699 | Tris(2-butoxyethyl) phosphate | Oral exposure to low-dose Tris (2-butoxyethyl) phosphate (TBEP) levels equivalent to tolerable daily intake may exacerbate allergic pulmonary inflammation by promoting a skewed T-helper 2 cell response, upregulation of ERα and dysregulation of both MLN and BM microenvironments. | ||
| E3387 | Sophora flavescens Extract | Sophora Flavescens Extract is extracted from Sophora flavescens, which is used in the treatment of ulcerative colitis with damp-heat accumulation syndrome. | ||
| A2114New | Anti-mouse NK1.1-InVivo | The PK136 monoclonal antibody(Clone: PK136) reacts with mouse NK1.1 also known as CD161b/CD161c, KLRB1, NKR-P1A and Ly-55. |
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| E3389 | Sophora alopecuroides seed Extract | Sophora Alopecuroides Seed Extract is extracted from the seeds of Sophora alopecuroides, which has anti-inflammatory activities. | ||
| S5016 | Isoprinosine | Isoprinosine (Inosine pranobex, Immunovir, Groprinosin, Delimmun) is an immunopharmacologic agent with antiviral activities. | ||
| S9061 | Hydroxy safflor yellow A | Hydroxy safflor yellow A, a monomer extracted from Carthamus tinctorius L., possesses various kinds of bio-activities, including anti-oxidation, anti-inflammatory actions, anti-platelet aggregation, anti-tumor and anti-myocardial injury effects. | ||
| A2108 | Anti-mouse CD28-InVivo | The PV-1 monoclonal antibody(Clone: PV-1) reacts with mouse CD28.The PV-1 antibody has been shown to stimulate the proliferation and cytokine production by activated T and NK cells. | ||
| S3774 | Dehydroandrographolide Succinate Potasium Salt | Dehydroandrographolide Succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect. | ||
| S0836 | TMN355 | TMN355 (Compound 3i) is a potent inhibitor of cyclophilin A (CypA) with IC50 of 1.52 nM and reduces foam cell formation and cytokine secretion. TMN355 is used for the treatment of atherosclerosis. | ||
| S3775 | Ligustrazine hydrochloride | Ligustrazine hydrochloride (Tetramethylpyrazine, Tetrapyrazine) is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities. | ||
| S9064 | Trilobatin | Trilobatin (P-Phlorizin), a natural flavonoid lipid molecule, is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope and exihibits anti-oxidant and anti-inflammatory effect. | ||
| S6404 | Salicylamide | Salicylamide (o-hydroxybenzamide) is a non-prescription drug with analgesic and antipyretic properties. | ||
| A2110 | Anti-mouse CD16/CD32-InVivo | The 2.4G2 monoclonal antibody (Clone: 2.4G2)reacts specifically with mouse CD16 (FcγRIII) and CD32 (FcγRII). It has also been reported to react non-specifically via its Fc domain to FcγRI. The 2.4G2 antibody is commonly used in flow cytometry staining experiments to prevent non-specific binding of IgG to the FcγIII and FcγII, and possibly FcγI, receptors prior to staining with antigen specific primary antibodies. |
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| S3776 | Sophoricoside | Sophoricoside (SOPH) is an isoflavone isolated from Sophora japonica (Leguminosae) with numerous pharmacological effects, including anti- inflammatory, anti-cancer and immunosuppressive effects. | ||
| A2111New | Anti-human CD3-InVivo | The OKT-3 monoclonal antibody reacts with human CD3ε which is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily.The OKT-3 antibody has immunosuppressive properties in vivo and has been shown to effectively treat renal, heart and liver allograft rejection. | ||
| E3589 | Evodia Lepta Bark Extract | Evodia Lepta Bark Extract is extracted from the bark of Melicope pteleifolia, which has anti-inflammatory activity. | ||
| E1134 | ABR-238901 | ABR-238901 is a novel S100A8/A9 blocker that potently inhibits S100A8/A9 interaction with its receptors RAGE (receptor for advanced glycation endproducts) and TLR4 (toll-like receptor 4). | ||
| A2112 | Anti-mouse CD40L (CD154)-InVivo | The MR-1 monoclonal antibody reacts with mouse CD154 also known as CD40 ligand. The MR-1 monoclonal antibody has been reported to inhibit in vitro activation of B lymphocytes by blocking the binding of CD154 with CD40 on T helper cells as well as inhibit the formation of germinal centers and disrupt antigen-specific T cell responses. Additionally, the MR-1 antibody blocks interactions of T cells and antigen-presenting cells in vitro and blocks the development of experimental autoimmune disease in vivo. | ||
| E3397 | Coltsfoot Extract | Coltsfoot Extract is extracted from Tussilago farfara, which is used for relieving inflammatory conditions, as well as respiratory and infectious diseases in humans. | ||
| S9067 | Pseudoprotodioscin | Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides. | ||
| S9036 | (20R)Ginsenoside Rh2 | (20R)Ginsenoside Rh2, a natural compound found in Panax ginseng, shows antiviral and anticancer activities. It is a matrix metalloproteinase (MMP) inhibitor., | ||
| S9068 | Trillin | Trillin (Disogluside, Diosgenin glucoside) is an active ingredient isolated from Trillium tschonoshii Maxim and acts as a potential anti-inflammatory drug for chronic hepatic inflammation. | ||
| S9384 | Sophocarpine Monohydrate | Sophocarpine, a naturally occurring tetracyclic quinolizidine alkaloid derived from Sophora alopecuroides L, has shown promising therapeutic properties, including anti-inflammatory, anti-nociceptive, and antivirus activities. | ||
| E1386 | KP-457 | KP-457 (TNF-α-converting enzyme) is a selective inhibitor of ADAM17 with IC50 of 11.1 nM/L (cell-free assay). It also cleaves various molecules such as GPIbα, GPV, and TNF-α. | ||
| S9072 | Sweroside | Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects. | ||
| S5044 | Isoxepac | Isoxepac is a non-steroidal arylacetic acid derivative with anti-inflammatory, analgesic and antipyretic activity. | ||
| E3596 | Phellinus linteus Extract | Phellinus Linteus Extract is extracted from Phellinus Linteus, which has immunomodulatory effect. | ||
| E3404 | Raphanus sativus seed Extract | Raphanus sativus seed Extract is extracted from the seeds of Raphanus sativus, which has wound-healing characteristics. | ||
| S5046 | Clonixin | Clonixin (Clonixic acid) is a nonsteroidal anti-inflammatory drug with analgesic, antipyretic, and platelet-inhibitory actions. | ||
| S3790 | Methyl gallate | Methyl Gallate (Methylgallate, Gallic acid methyl ester, Gallicin) is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities. | ||
| S5162 | Isovanillic acid | Isovanillic acid (Acide isovanillique, 3-Hydroxyanisic acid, 3-Hydroxy-p-anisic acid), a metabolite of isovanillin, is a selective inhibitor of neutrophil migration into inflamed tissue. | ||
| E3658 | Double coptis chinensis Extract | Double Coptis Chinensis Extract is extracted from Double Coptis Chinensis, which has antipyretic and anti-inflammatory mechanism. | ||
| A2970 | Ociperlimab (Anti-TIGIT) | Ociperlimab (anti-TIGIT) is a humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting the co-inhibitory molecule and immune checkpoint inhibitor T-cell immunoreceptor with immunoglobulin (Ig) and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT), with potential immune checkpoint inhibitory activity. MW: 145.12 kD. | ||
| S9083 | Rhapontin | Rhapontin (Ponticin, Rhaponticin, Rhapontigenin glucoside), a stibene-type glycoside distributed widely in medicinal plants of Rheum genus (Polygonaceae), has anti-inflammatory effect and anti-proliferative activity. | ||
| S9084 | Rhoifolin | Rhoifolin (Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside), a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects. | ||
| S3799 | Gentisic acid | Gentisic acid (2,5-dihydroxybenzoic acid, 5-Hydroxysalicylic acid, Hydroquinonecarboxylic acid, DHB), an active metabolite of salicylic acid degradation, has a broad spectrum of biological activity, such as anti-inflammatory, antirheumatic and antioxidant properties. | ||
| S9085 | Corynoline | Corynoline is one of the major active components of many ethnopharmacological plants and exhibits anti-tumor, anti-inflammatory and hepatoprotective activities, etc. | ||
| S9405 | Sesamoside | Sesamoside, a main chemical ingredient iridoid glycoside from Lamiophlomic rotata, has analgesic and anti-inflammatory effects in animal studies. | ||
| E3696 | Panax notoginseng Extract | Panax notoginseng Extract is is made from the dry roots of Panax notoginseng, which is used to treat inflammation and bleeding, also inhibits Streptococcus pyogenes without affecting oral commensal bacteria. | ||
| S9088 | Calycosin-7-O-beta-D-glucoside | Calycosin-7-O-beta-D-glucoside, an isoflavone glycoside isolated from A. mongholicus and A. membranaceus, has antioxidant, anti-inflammatory, and neuroprotective biological activities. | ||
| S9406 | Sauchinone | Sauchinone, one of the active lignan isolated from the roots of Saururus chinensis, possesses diverse pharmacological properties, such as hepatoprotective, anti-inflammatory and anti-tumor effects. | ||
| E3578 | Fringed pink Extract | Fringed Pink Extract is extracted from Dianthus superbus, which has anti-inflammatory activity. | ||
| E3418 | Rhizoma Anemones Raddeanae Extract | Rhizoma Anemones Raddeanae Extract is extracted from the rhizome of Anemone raddeana Regel, which is used to treat wind and cold symptoms, hand-foot disease and spasms, joint pain, and ulcer pain. | ||
| S9407 | Angoroside C | Angoroside C, an important phenylpropanoid glycoside of the traditional Chinese medicine Scrophulariae Radix, possesses the effects of preventing ventricular remodeling, reducing pulmonary oedema, and reducing blood pressure, as well as having the properties of anti-platelet aggregation, hepatoprotection and anti-nephritis, etc. | ||
| S9090 | Corilagin | Corilagin, discovered in many medicinal plants such as Phyllanthus speices etc., has multiple activities including anti-oxidative, anti-inflammatory, anti-apoptotic, hepatoprotective and others. It is an inhibitor of TNF-α. | ||
| S9408 | Beta-Elemonic acid | Beta-Elemonic acid (3-Oxotirucallenoic Acid), a known triterpene isolated from Boswellia (Burseraceae), exhibits anti‑inflammatory effects. | ||
| S9091 | 10-Gingerol | 10-Gingerol is a bioactive compound found in ginger with anti-inflammatory and antioxidant activity. | ||
| E3702 | Eupolyphage sinensis Walker Extract | Eupolyphage sinensis Walker Extract is aqquired from the aqueous extract of Eupolyphaga sinensis Walker, which shows a potency to potentiate immune responses in mice. | ||
| E4964New | ATP (disodium trihydrate) | ATP disodium trihydrate, is the primary energy currency of the cell, essential for intracellular energy metabolism. It regulates extracellular biological processes, including cardiac function, neurotransmission, muscle contraction, vasodilation, bone and liver glycogen metabolism, and inflammation. It also plays a crucial role in initiating immune responses during infections. | ||
| S4753 | Ganoderic acid A | Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities. | ||
| E3704 | Rumex madaio Makino Extract | Rumex Madaio Makino Extract is derived from Rumex madaio Makino (Polygonaceae), leaf and root tissues of which can be used as medicine such as clearing heat and detoxification, removing blood stasis, and defecating and killing insects. | ||
| S3881 | Scopoletin | Scopoletin (Esculetin 6-methyl ether, Gelseminic acid, 6-Methylesculetin, Chrysatropic acid) is the main bioactive constituent of flower buds from Magnolia fargesii with anti-inflammatory, hypouricemic, and antioxidant activities. | ||
| S9095 | Senegenin | Senegenin (Tenuigenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and antiinflammatory activity. | ||
| S5834 | p-Coumaric acid ethyl ester | p-Coumaric acid ethyl ester is the ethyl ester of p-Coumaric acid, which is a plant metabolite which exhibits antioxidant and anti-inflammatory properties. | ||
| S9512 | 1,3-Dicaffeoylquinic acid | 1,3-Dicaffeoylquinic acid (Cynarin; Cinarine; 1,5-Dicaffeoylquinic acid) is a phenolic compound found in artichoke. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent. | ||
| E3124 | Cirsii Japonici Herba Extract | Cirsii Japonici Herba Extract is extracted from Cirsii Japonici, which can be used in the treatment of chronic glomerulonephritis. | ||
| E3426 | Piper betle L. Extract | Piper Betle L. Extract is extracted from Piper betel l., which is a potential source of wound healing agents. | ||
| S9417 | Homoplantaginin | Homoplantaginin (Hispidulin-7-glucoside), a main flavonoid from a traditional Chinese medicine Salvia plebeia, has anti-inflammatory and anti-oxidant properties. Homoplantaginin inhibits TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation. | ||
| S9098 | Dehydrodiisoeugenol | Dehydrodiisoeugenol, a naturally occurring lignan from Aristolochia taliscana (Aristolochiaceae), acts as a potent anti-inflammatory agent and shows various pharmacological activities, including anti-lipid peroxidation, anti-bacteial function, and hepatic drug metabolism enzyme inhibition. | ||
| S9099 | Orientin | Orientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects. | ||
| S9100 | Fraxinellone | Fraxinellone is a natural product isolated from the D. dasycarpus plant, which has been shown to exhibit neuroprotective and anti-inflammatory activities. | ||
| S6073 | Diclofenac acid | Diclofenac acid is a nonsteroidal anti-inflammatory drug that has analgesic, anti-inflammatory, and antipyretic properties, and has been shown to be effective in treating a variety of acute and chronic pain and inflammatory conditions. It inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency. | ||
| E3713 | Vaccariae semen Extract | Vaccariae semen Extract is drawed from the dried ripe seed of Vaccaria hispanica (Mill.) Rauschert, which has been used to treat stranguria disease, e.g. benign prostatic hyperplasia (BPH) and urinary infection. | ||
| E3714 | Clematis chinensis Extract | Clematis Chinensis Extract is derived from the dry root of Clematis chinensis Osbeck (Ranunculaceae), which is widely used in the management of various arthritis related conditions. | ||
| E3715 | Crinum Asiaticum Extract | Crinum Asiaticum Extract is drawed from Crinum asiaticum L. var. sinicum (Roxb. ex Herb.) Baker, which is applied in clinic for the treatment of anti-inflammatory, activating blood, especially purpura, rheumatic arthralgia, traumatic injury and also used to treat cancer nowadays. | ||
| S4706 | Eugenol | Eugenol (4-Allyl-2-methoxyphenol, 4-Allylguaiacol, Eugenic acid, Allylguaiacol) is a naturally occuring scent chemical found in clove oil and other plants. The physiologic effect of eugenol is by means of increased Histamine Release, and cell-mediated Immunity. | ||
| S9106 | Eleutheroside E | Eleutheroside E, a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory effects by inhibiting NF-κB and protecting against myocardial infarction. | ||
| S9425 | Trifolirhizin | Trifolirhizin, a natural pterocarcan flavonoid extracted from Sophora flavescens, has many pharmacological activities, such as hepatoprotective, anti-inflammatory, anti-proliferation, and skin-whitening. | ||
| A2033 | Vibostolimab (anti-TIGIT) | Vibostolimab (anti-TIGIT, MK-7684) is a humanized monoclonal antibody that binds to the T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT), blocking the interaction between TIGIT and its ligands, CD112 and CD155, thereby activating T lymphocytes which help to destroy tumor cells. | ||
| E3717 | Lactuca sativa Extract | Lactuca Sativa Extract is derived from Lactuca sativa (Compositae), the seeds of this plant are used for relieving of inflammation and osteodynia. | ||
| S9427 | Tabersonine | Tabersonine is a terpene indole alkaloid found in the medicinal plant Catharanthus roseus and shows hypotensive activity, anti-tumor activity, hypoglycemic, diuretic activity. | ||
| E3718 | Glaucescent Fissistigma Root Extract | Glaucescent Fissistigma Root Extract is obtained from the root of Fissistigma glaucescens (Hance) Merr. (Annonaceae), which may play an anti-tumor role by improving immune function. | ||
| S5579 | Chelidonic acid | Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid) is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals. Chelidonic acid inhibits IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. Chelidonic acid is also an inhibitor of glutamate decarboxylase with Ki of 1.2 μM. | ||
| E3440 | Tamarindus indica seed Extract | Tamarindus indica seed Extract is extracted from the seeds of Tamarindus indica, which helps to reduce inflammation and inflammation-induced cartilage degeneration. | ||
| S9431 | Dehydrocorydalin | Dehydrocorydalin is an alkaloidal component isolated from Rhizoma corydalis. It has anti-inflammatory and anti-tumor effects and can protect the cardiovascular system. | ||
| E3145 | Kochiae Fructus Extract | Kochiae Fructus Extract is obtained from dried fruit of Kochia scoparia (L.) Schrad., broom cypress fruit), has attracted considerable attention for its pharmacological activities, including antiinflammation, antidiabetics, insecticide, antianaphylaxis, antipruritic and anti-rheumatoid arthritis. | ||
| E3722 | Zaocys dhumnades Extract | Zaocys Dhumnades Extract is derived from the dried body of adult Zaocys dhumnades, which is effective in the dispelling cold or wind, dredging meridians, sedation, and mainly used in the treatment of rheumatism, leg and hand’s numb, paraplegic, twitching spasms, as well as tetanus, leprosy acariasis in China and other Asian countries. | ||
| S9112 | Kaempferitrin | Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities. | ||
| S9113 | Ononin | Ononin (Formononetin glucoside, Formononetin 7-O-glucoside) is an isoflavone glycoside with anti-inflammtory effects. | ||
| S9433 | Tubeimoside II | Tubeimoside II (Tubeimoside B), a natural triterpenoid saponin isolated from herb, show anti-inflammatory, antitumor, and antitumor-promoting effects. | ||
| S4709 | Latanoprost | Latanoprost (Xalatan, PhXA41) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure. | ||
| E3149 | Pheretima Extract | Pheretima Extract is extracted from Pheretima, which has effects on various inflammatory diseases such as asthma, cough, and fever. | ||
| E3445 | Hibiscus sabdariffa flower Extract | Hibiscus sabdariffa flower Extract is extracted from the flowers of Hibiscus sabdariffa, which enhances anti-inflammatory effects by increasing expression of anti-inflammatory cytokines and decreasing pro-inflammatory cytokines. | ||
| E0202 | Benzoylmesaconine | Benzoylmesaconine (Mesaconine 14-benzoate) is a main Aconitum alkaloid isolated from several Aconitum species with potent pharmacological activities, such as analgesia and anti-inflammation. | ||
| E3446 | Chinese Starjasmine stem Extract | Chinese Starjasmine Stem Extract is extracted from the stem of Trachelospermum jasminoides, which is used in the treatment of inflammation-related diseases. | ||
| S9116 | Chikusetsusaponin IVa | Chikusetsusaponin IVa (Calenduloside F), a major active ingredient of triterpenoid saponins, has numerous pharmacological activities, including cytotoxic activity against various cancer cells, anti-inflammatory activity, prevention of dental caries and induction of genta-micin nephrotoxicity. Chikusetsusaponin IVa is a novel AMPK activator. | ||
| E3739 | Panax quinquefolium Extract | Panax Quinquefolium Extract is extracted from Panax quinquefolium L. (American Ginseng, AG), its active compounds—ginsenosides—have been documented to exert a wide range of different biological activities resulting in hypoglycemic, anti-inflammatory, cardio protective, and anti-tumor effects. | ||
| S9437 | Echinatin | Echinatin is a licorice extract that displays antioxidant properties and anti-inflammatory activities. | ||
| S6439 | Talniflumate | Talniflumate (MSI-1995) is an anti-inflammatory molecule studied and used as a mucin regulator in the treatment of cystic fibrosis, chronic obstructive pulmonary disease (COPD) and asthma. Talniflumate is also an inhibitor of human calcium-activated chloride channels. | ||
| S6448 | Ibuprofen piconol | Ibuprofen piconol (U75630) is a non-steroidal, anti-inflammatory (NSAID) drug for the topical relief of primary thermal burns and sunburns. | ||
| E0205 | Strictosamide | Strictosamide is the main representative constituent of Nauclea officinalis Pierre ex Pitard (Rubiaceae) with anti-inflammatory and analgesic activities. | ||
| S3106 | Pidotimod | Pidotimod(Pidotomod) is an immunostimulant. | ||
| S9120 | Scutellarein | Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities | ||
| S9439 | Kaurenoic acid | Kaurenoic acid (kaurenoate, kaur-16-en-18-oic acid) is a natural diterpenoid found in the herbs of Croton antisyphiliticus. Kaurenoic acid has anti-inflammatory activity, the mechanisms may through inhibition of iNOS and COX-2 expression. | ||
| S9440 | Naringenin chalcone | Naringenin chalcone (Chalconaringenin, Isosalipurpol, trans-2'4'6'4-tetrahydroxychalcone) is the main active component of tomato skin extract, has been proposed as an antioxidant, an anti-inflammatory, and a regulator of fat and sex hormone metabolism. | ||
| S6472 | Tinoridine hydrochloride | Tinoridine hydrochloride (Y-3642) is a non-steroidal anti-inflammatory drug with a potent antiperoxidative activity. | ||
| E3157 | Erycibes Caulis Extract | Erycibes Caulis Extract is extracted from Erycibes Caulis, which is used in the treatment of rheumatoid arthritis. | ||
| S3892 | Isopsoralen | Isopsoralen (Angelicin), also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses. | ||
| S9123 | Eriodictyol | Eriodictyol, a flavonoid extracted from yerba santa, has anti-inflammatory and antioxidant activities and taste-modifying properties. | ||
| S9125 | Apigetrin | Apigetrin (Cosmetin, Cosmosioside, Thalictiin, Cosmosin, Apigenin 7-glucoside), a flavonoid found in many plant leaves and seeds, has been known to possess antimutagenic, anti-cancer, antioxidant and anti-inflammatory properties. | ||
| E3748 | Epimedium Extract | Epimedium Extract is extracted from Epimedium, which has been preliminarily proven to show anti-osteoporotic and anti-inflammatory effects in OA. | ||
| A2571 | Anti-CCL5 / RANTES | Anti-CCL5 / RANTES (NI-0701) is a antibody tageting CCL5. MW:145.5 KD. | ||
| S9128 | Isoacteoside | Isoacteoside, a phenylethanoid isolated from Monochasma savatieri Franch. ex Maxim., is an anti‐inflammatory herb widely used in traditional Chinese medicine. | ||
| S9129 | 20(S)-Ginsenoside Rh1 | 20(S)-Ginsenoside Rh1 (Prosapogenin A2, Sanchinoside B2, Sanchinoside Rh1) is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. It exhibits potent characteristics of anti-inflammatory, antioxidant, immunomodulatory effects, and positive effects on the nervous system. Ginsenoside Rh1 inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β. | ||
| E3164 | Malvae Fructus Extract | Malvae Fructus Extract is extracted from Malvae Fructus, which helps to open the veins, induce diuresis and disperse swelling, dry pus, relieve diarrhea, quench thirst, and is used to treat ischuria and bladder stones. | ||
| E3750 | Opuntia dillenii Extract | Opuntia Dillenii Extract is extracted from Opuntia dillenii Haw (Nagphana), which is traditionally used against inflammation. | ||
| A2573 | Carlumab (Anti-CCL2 / MCP1) | Carlumab (Anti-CCL2 / MCP1) is a humanised monoclonal antibody targeting CCL2 with high affinity. Carlumab can be used in cancer research, particularly in prostate cancer. MW:145.5 KD. | ||
| E3165 | Rabdosiae Rubescentis Herba Extract | Rabdosiae Rubescentis Herba Extract is drawed from the dried aerial part of genus Rabdosia rubescens (Hemsl.) Hara of the Lamiaceae family, which possesses several biological activities, such as anti-bacteria, anti-parasites, anti-inflammation, and anticancer. | ||
| E3462 | Coriaria Root Extract | Coriaria Root Extract is extracted from the roots of coriaria, which is used to treat numbness, toothaches due to wind and heat, phlegm-retention syndrome, traumatic injury, and acute conjunctivitis. | ||
| S4690 | Escin | Escin (Aescin) is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum(the horse chestnut). | ||
| S9132 | Harpagide | Harpagide, isolated from the secondary roots of Harpagophytum procumbens (Hp), has valuable medicinal properties, such as anti-inflammatory, analgesic and potential antirheumatic effects. | ||
| E3760 | Cymbopogon Citratus Extract | Cymbopogon Citratus Extract is derived from Cymbopogon citratus DC (Stapf.), which has antimicrobial, antiprotozoal, anti-rheumatic, antitumoural, cardio-protective, anti-inflammatory and gastroprotective properties. | ||
| S9136 | Neochlorogenic acid | Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia. | ||
| S2307 | Roquinimex | Roquinimex (FCF 89, Linomide, LS 2616) is a novel immunomodulator augmenting natural killer (NK) cell activity and T-lymphocyte related effector functions. Roquinimex is a potent oral active tumor antiangiogenic agent. Roquinimex inhibits the secretion of TNF-α. | ||
| E3470 | Mango leaf Extract | Mango Leaf Extract is extracted from the leaves of Mangifera indica, which attenuates muscle pain and damage and accelerates the recovery of muscle performance. | ||
| S4789 | 5-Acetylsalicylic acid | 5-Acetylsalicylic acid (5-acetyl-2-hydroxybenzoic acid) is a nonsteroidal anti-inflammatory drug. | ||
| E3472 | Spicate clerodendranthus Extract | Spicate Clerodendranthus Extract is extracted from Spicate Clerodendranthus, which has curative effects on respiratory inflammation and upper respiratory diseases such as parched mouth, kakostomia, and bitter taste. | ||
| E3473 | Ternate buttercup root Extract | Ternate Buttercup Root Extract is extracted from the roots of Ternate Buttercup, which boosts the activity of the immune system, reduces inflammation, scavenges damaging particles known as free radicals, and destroys cancerous cells. | ||
| E3767 | Justicia Gendarussa Extract | Justicia Gendarussa Extract is obtained from Justicia gendarussa, which is useful in asthma, rheumatism and colics of children, also may have the potential to be the basis for a birth control pill for men. | ||
| S9144 | Solasonine | Solasonine, a natural glycoalkaloid compound, has anti-inflammation and anti-tumor properties. | ||
| E3477 | Rose hip Extract | Rose Hip Extract is extracted from the fruits of Rosa L., which is used to treat kidney stones, gastro-enteric ailments, hypertension, and respiratory problems such as bronchitis, cough, and colds. | ||
| S9220 | Stylopine hydrochloride | Stylopine (Tetrahydrocoptisine, Coptisine), a major component of the leaf of Chelidonium majus L., is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity. | ||
| E3482 | Buddleja Officinalis Extract | Buddleja Officinalis Extract is drawed from Buddleja officinalis flower, which is reportedly effective in treating inflammation, conjunctival hypertension, and headache in traditional oriental herbal medicine. | ||
| S5043 | Benorylate | Benorylate (Benorilate, Benoral, Benortan) is the esterification product of paracetamol and acetylsalicylic acid with anti-inflammatory, analgesic and antipyretic properties. | ||
| S9148 | Peiminine | Peiminine (Verticinone, Zhebeinone, Raddeanine), a biologically active component extracted from Fritillaria walujewii Regel, has been reported to have potent anti-inflammatory, antitussive, and expectorant effects. It induces autophagic cell death thus represses colorectal carcinoma tumor growth. | ||
| S9488 | Praeruptorin D | Praeruptorin D, a major pyranocoumarin isolated from Radix Peucedani, exhibits antitumor and anti-inflammatory activities. | ||
| E0208 | Herbacetin | Herbacetin is a natural flavonoid compound found in flaxseed with strong antioxidant, antitumor and anti-inflammatory activity. |
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| S9264 | Decursin | Decursin is a pyranocoumarin obtained from the roots of Angelica gigas Nakai that exhibits anti-cancer, anti-inflammatory and neuroprotective activities. | ||
| E3487 | Ecliptae Herba Extract | Ecliptae Herba Extract is extracted from Eclipta, which has an anti-osteoporotic effect. | ||
| A2044 | Omalizumab (anti-IgE) | Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) with a KD of 0.393 nM. Omalizumab binds to the human FcγRIIb receptors with a KD of 6.37 uM. Omalizumab has the potential for persistent allergic asthma research. | ||
| E3001 | Donkey-hide gelatin Extract | Donkey-Hide Gelatin Extract is extracted from Donkey-hide gelatin (Asini Corii Colla, ACC), a gelatinous Chinese medicine known as Ejiao in Chinese. Donkey-hide gelatin is applied as an important food therapy product to optimize immune response, improve metabolic balance and treat gynecological diseases. | ||
| S9920 | GYY4137 | GYY4137 is a novel, water-soluble hydrogen sulfide (H2S)–releasing molecule with vasodilator and antihypertensive activity. GYY4137 shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. GYY4137 also shows anti-inflammatory activity. | ||
| E3492 | Vitex negundo seed Extract | Vitex Negundo Seed Extract is extracted from the fruits of Vitex negundo, which is used in the treatment of rheumatism and joint inflammation. | ||
| E0193 | Mometasone Furoate Hydrate | Mometasone Furoate (SCH 32088) Hydrate is a synthetic glucocorticoid with anti-inflammatory activity. |
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| S9157 | Neoandrographolide | Neoandrographolide, a principle diterpenoids isolated from A. paniculata, exerts a wide range of therapeutic actions, including immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, anti-viral, anti-bacterial, anti-diabetic, anti-oxidative stress, antipyretic, anti-edematogenic, and anti-nociceptive activities. | ||
| E3494 | Oyster Shell Extract | Oyster Shell Extract is extracted from the shell of Ostreidae, which has an anti-inflammatory effect. | ||
| E0129 | Oxysophocarpine | Oxysophocarpine (OSC) is an alkaloid extracted from Sophora alopecuroides. Oxysophocarpine inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) by targeting the Nrf2/HO-1 axis. OSC protects cells against apoptosis and inflammatory responses and compromised miR-155 activity by attenuating MAPK and NF-κB pathways. | ||
| S4524 | 2-Ethoxybenzamide | 2-Ethoxybenzamide (Ethenzamide) is a common analgesic and anti-inflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains. | ||
| S5466 | Saikosaponin A | Saikosaponin A is a triterpene saponin derived from the medicinal plant, Bupleurum chinensis DC. (Umbelliferae). It has a variety of pharmacological benefits, including anti-inflammatory, immunomodulatory, and anti-bacterial activities. | ||
| E3497 | Momordicae Semen Extract | Momordicae Semen Extract is extracted from Momordicae semen, which has anti-gastritis and wound healing effects. | ||
| S5463 | Curcurbitacin IIA | Curcurbitacin IIA (Cucurbitacin Iia, CuIIa, Hemslecin A, Dihydrocucurbitacin Q1) is a triterpene isolated from Hemsleya amalils Diels, induces apoptosis of cancer cells, reduces expression of survivin, reduces phospho-Histone H3 and increases cleaved PARP in cancer cells. | ||
| S9161 | Ziyuglycoside II | Ziyuglycoside II is an active compound of Sanguisorba officinalis L. that has anti-inflammation, antioxidation, antibiosis, and homeostasis properties. | ||
| E0131 | Luteolin-7-O-glucuronide | Luteolin-7-O-glucuronide (Luteolin 7-glucuronide) is a flavone glycoside found in plants. Luteolin-7-O-glucuronide possesses anti-microbial, antioxidant, anti-mutagenic, anti-genotoxic, anti-inflammatory, and anti-arthritic activities. |
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| E3787 | Flos Inulae Extract | Flos Inulae Extract is drawed from Flos Inulae, which can be applied to antimutation, antityrosinase and anti-inflammation. | ||
| S3906 | Astragalus polyphenols | Astragalus polyphenols(2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucopyranoside) is a wonderful immune enhancing herb that has strong anti-viral activity and produces extra interferon in the body. It contains rich polyphenol with various effects including antioxidant and antiinflammatory actions. | ||
| E0222 | Glaucocalyxin A | Glaucocalyxin A is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx with antitumor and anti-inflammatory activity. Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells. |
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| S9551 | Uvaol | Uvaol is a pentacyclic triterpene, found in the non-glyceride fraction of olive pomace oil, exhibiting both pro- and anti-inflammatory properties. | ||
| E3789 | Saussurea Involucrata Extract | Saussurea Involucrata Extract is drawed from the flower of Saussurea involucrata Matsum. & Koidz., which has long been used to treat rheumatoid arthritis, cough with cold, stomach ache, dysmenorrhea, and altitude sickness in Uyghur and Chinese medicine. | ||
| S9165 | Poncirin | Poncirin (Isosakuranetin-7-neohesperidoside), extracted from trifoliate orange, has anti-bacterial and anti-inflammatory activities. | ||
| E0226 | Chebulagic acid | Chebulagic acid, isolated form Terminalia chebula Retz, is a reversible and non-competitive inhibitor of maltase with a Ki value of 6.6 μM. Chebulagic acid shows potent anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. Chebulagic acid also shows potent COX–LOX dual inhibition activity with IC50 values of 15 μM, 0.92 μM and 2.1 μM for COX-1, COX-2 and 5-LOX respectively. |
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| E3476 | Myrrh Extract | Myrrh Extract is extracted from Commiphora myrrha, which is used in the therapy of inflammatory bowel diseases. | ||
| S9167 | Columbin | Columbin, a diterpenoid furanolactone, is a potential anti-inflammatory drug. | ||
| S9560 | Anisodamine Hydrobromide | Anisodamine (6-Hydroxyhyoscyamine) is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs). | ||
| E0233 | 14-Deoxy-11,12-didehydroandrographolide | 14-Deoxy-11,12-didehydroandrographolide (deAND), a diterpenoid in Andrographis paniculata (Burm. f.) Nees with hypotensive, anti-inflammatory, anti-asthma, and anti-cancer activities. |
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| E3791 | Surgentodoxa Cuneata Extract | Surgentodoxa Cuneata Extract is drawed from Surgentodoxa Cuneata, which has anti-inflammatory, antioxidant, antitumor, antimicrobial, and anti-sepsis activities. | ||
| S5360 | Diflorasone | Diflorasone acts as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties. | ||
| E3793 | Urtica Fissa Extract | Urtica Fissa Extract is extracted from Urtica fissa (Urticaceae), rhizomes (Urticae Rhizoma, Qianma Gen in Chinese) of which is a commonly-used enthnomedicine for the treatment of rheumatism and urticaria in Chinese traditional medicine. | ||
| S9171 | Harpagoside | Harpagoside, a natural product found in the plant Harpagophytum procumbens, has potent anti-rheumatic, anti-inflammatory and analgesic effects. | ||
| E3500 | Agaric Extract | Agaric Extract is extracted from agaricales, which has anti-inflammatory and related pharmacological activities. | ||
| S9172 | Phellodendrine | Phellodendrine, a quaternary ammonium alkaloid extracted from the dried bark of Phellodendrom chinensis Schneid and Phellodendrom amurense Rupr, has the effect of suppressing cellular immune response, reducing blood pressure and antinephritis. | ||
| S6742 | Etofenamate | Etofenamate is a nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain. | ||
| E3501 | Hibiscus mutabilis flower Extract | Hibiscus Mutabilis Flower Extract is extracted from the flowers of Hibiscus mutabilis, which has allergy-preventive effects. | ||
| S5412 | Loxoprofen Sodium | Loxoprofen sodium is a non-steroidal anti-inflammatory drug. | ||
| S9174 | Xanthotoxol | Xanthotoxol (8-Hydroxypsoralen, 8-Hydroxypsoralene, 8-Hydroxyfuranocoumarin, Psoralen), a biologically active linear furocoumarin found in a large number of plants, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects. | ||
| S9175 | Macranthoidin A | Macranthoidin A, found in the herbs of Lonicera japonica Thunb., has anti-inflammation activity. | ||
| A2802 | Cobolimab (Anti-TIM-3 / HAVCR2 / CD366) | Cobolimab (Anti-TIM-3 / HAVCR2 / CD366) is a monoclonal antibody against the inhibitory T-cell receptor, T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3; TIM3; hepatitis A virus cellular receptor 2; HAVCR2), with potential immune checkpoint inhibitory and antineoplastic activities. MW : 142.84 KD. | ||
| E0148 | Linalyl Acetate | Linalyl Acetate (Bergamiol, Bergamol, Linalool acetate) is a naturally occurring phytochemical found in many flowers and spice plants. Linalyl Acetate is a potentially anti-inflammatory agent. |
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| S9180 | Tussilagone | Tussilagone, isolated from the flower of buds of Tussilago farfara (Compositae), is a sesquiterpenoid that is used as a traditional oriental medicine for asthma and bronchitis. It shows anti-inflammatory activity in in vitro studies. | ||
| E0780 | MNITMT | MNITMT is a more potent immunosuppressive agent without bone marrow toxicity. | ||
| S5729 | Fosfosal | Fosfosal (2-phosphonoxy benzoic acid) is a non-acetylated salicylic acid derivative, with analgesic and anti-inflammatory activity, but without effects on PG biosynthesis in vitro. | ||
| S9183 | Ruscogenin | Ruscogenin, a major steroidal sapogenin of traditional Chinese herb Radix Ophiopogon japonicus, has been reported to exert significant anti-inflammatory and anti-thrombotic activities. | ||
| S5451 | Ferulic acid methyl ester | Ferulic acid methyl ester (Methyl Ferulate, Methyl 4'-hydroxy-3'-methoxycinnamate) is a lipophilic derivative of ferulic acid, which is a hydroxycinnamic acid that is abundant in plants. It shows the strongest antioxidant activity and can protect against inflammation and cancer. | ||
| S9184 | Forsythoside B | Forsythoside B is a phenylethanoid glycoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant. Forsythoside B has potent neuroprotective effects and has anti-inflammation, antioxidant, and antisepsis properties. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB. | ||
| S3928 | Baccatin Ⅲ | Baccatin Ⅲ is a polycyclic diterpene which can be used for the semi-synthesis of paclitaxel and analogs. It exhibits immunomodulatory and anticancer chemotherapeutic activities. | ||
| E0211 | Dihydroberberine | Dihydroberberine, a hydrogenated derivative of Berberine (BBR), exerts anti-inflammatory effect via dual modulation of NF-κB and MAPK signaling pathways. |
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| S2286 | Cyclosporin A | Cyclosporin A, a non-polar cyclic oligopeptide, is an immunosuppressive agent that binds to cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay. Cyclosporin A is generally given following transplant surgery to prevent rejection and has been used to test its toxic effect on a perfused 3D proximal tubule model. |
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| S7434 | TAPI-1 | TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP). |
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| S3032 | Bindarit | Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8. |
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| S1576 | Sulfasalazine | Sulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. Sulfasalazine is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. Sulfasalazine induces ferroptosis, apoptosis and autophagy. | ||
| S5004 | Pimecrolimus | Pimecrolimus (Elidel,ASM 981,SDZ-ASM 981) is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12 (FKBP-12); a calcineurin inhibitor. |
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| S1514 | Cyclosporine | Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. | ||
| S1654 | Phenylbutazone | Phenylbutazone (Butazolidine) is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis. | ||
| S8660 | GI254023X | GI254023X (GI 4023, SRI028594) is a selective inhibitor of ADAM10 with 100-fold selectivity for ADAM10 over ADAM17. The IC50 values for recombinant ADAM10 amd ADAM17 are 5.3 nM and 541 nM, respectively.GI254023X can inhibit MMP9. | ||
| S1591 | Bestatin (Ubenimex) | Bestatin (Ubenimex) is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia. |
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| S1622 | Prednisone | Prednisone is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound. | ||
| S8291 | Atractylenolide I | Atractylenolide I is the major sesquiterpenoid of the rhizome of A. macrocephala and shows a wide spectrum of pharmacological activities such as antiinflammatory, digestion promoting, and antioxidant effects. | ||
| S3758 | Sinomenine hydrochloride | Sinomenine (SN, Cucoline, Kukoline, Sabianine A), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent. | ||
| S3608 | Demethylzeylasteral (T-96) | Demethylzeylasteral (T-96), the active component isolated from Tripterygium wilfordii Hook F., inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects. | ||
| S4268 | Flufenamic acid | Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator. | ||
| S9032 | Sanguinarine | Sanguinarine (Pseudochelerythrine, Sanguinarin, Sanguinarium), a benzophenanthridine alkaloid known as an anti-inflammatory agent, is a potent inhibitor of NF-κB activation. | ||
| S6812 | Z-Guggulsterone | Z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Z-Guggulsterone exhibits anti-inflammatory effects in microglia. Z-Guggulsterone induces apoptosis in gastric cancer cells through the intrinsic mitochondria-dependent pathway. | ||
| S6239 | PMX-53 | PMX-53 is a potent CD88 (C5aR) antagonist and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2). | ||
| S5661 | Tiaprofenic acid | Tiaprofenic acid (Tiaprofensaeure, Acido tiaprofenico) is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain. | ||
| S9055 | Salvianolic acid A | Salvianolic acid A (Dan Phenolic Acid A), a water-soluble compound extracted from Radix Salvia miltiorrhiza (Danshen), is an antioxidant and free radical scavenging compound that also acts as an inhibitor of the protein-protein interaction mediated by SH2 domains of Src-family kinases Src and Lck. | ||
| E0206 | Ginkgetin | Ginkgetin is a biflavone from Ginkgo biloba leaves with anti-cancer, anti-inflammatory, anti-microbial, anti-adipogenic, and neuroprotective activities. |
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| S2512 | Tenoxicam | Tenoxicam(Ro-12-0068) is a good HO. radicals scavenger with an IC50 of 56.7 μM. | ||
| S3622 | Diammonium Glycyrrhizinate | Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1. | ||
| S5361 | Bendazac | Bendazac (bendazolic acid, AF-983) is a non-steroidal anti-inflammatory drug that delays the cataractogenic process. It may act by preventing protein denaturation. | ||
| E0150 | Carrageenan | Carrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. Carrageenan shows anticoagulant activity, antithrombotic activity, antiviral activity, anti-tumour activity and immunomodulatory activity. |
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| E3530 | Boat-fruited sterculia seed Extract | Boat-Fruited Sterculia Seed Extract is extracted from the seeds of boat-fruited sterculia, which has an inhibitive effect on acute inflammation. | ||
| E3824 | Scepteridium Ternatum Extract | Scepteridium Ternatum Extract is extracted from Scepteridium ternatum, which is used for the treatment of asthma. | ||
| S0920 | Ginkgolide J | Ginkgolide J is a minor constituent of terpene trilactone mixture of Ginkgo biloba leaves extract that inhibits GlyR-operated channels with IC50 of 2.0 μM. Ginkgolide J also inhibits cell death of rodent hippocampal neurons caused by Aβ1–42. Ginkgolide J exhibits anti‑inflammatory activity. | ||
| E3829 | Epimedium Brevicornu Extract | Epimedium Brevicornu Extract is extracted from Epimedium brevicornu Maxim, which has anti-inflammatory effects. | ||
| E3834 | Jasminum Nudiflorum Extract | Jasminum Nudiflorum Extract is extracted from Jasminum nudiflorum, which helps in treating dermatosis, coryza, nasal haemorrhage, infections, and wounds. | ||
| E3839 | Houttuynia Cordata Extract | Houttuynia Cordata Extract is extracted from Houttuynia cordata, which ameliorates bladder damage and improves bladder symptoms via anti-inflammatory effects. | ||
| E3840 | Ulmus Pumila Bark Extract | Ulmus Pumila Bark Extract is extracted from the bark of Ulmus pumila L., which prevents inflammatory diseases mediated by excessive production of nitric oxide. | ||
| E3554 | Rhizoma homalomenae Extract | Rhizoma Homalomenae Extract is extracted from Rhizoma Homalomenae, which has anti-inflammatory activity. | ||
| E3555 | Acmella oleracea Extract | Acmella Oleracea Extract is extracted from Acmella Oleracea, which can decrease chymase activity, oxidative stress, and inflammation. | ||
| S9033 | Incensole acetate | Incensole acetate, isolated from Boswellia Resin, is a novel anti-inflammatory compound that inhibits NF-κB activation. | ||
| E3074 | Xanthium Sibiricum Extract | Xanthium Sibiricum Extract is extracted from Xanthium Sibiricum, which has anti-inflammatory activity. | ||
| E3559 | Radix rubiae Extract | Radix Rubiae Extract is extracted from Rubia cordifolia, which has anti-tumor, anti-oxidative, anti-platelet aggregation, and anti-inflammatory effects. | ||
| E3852 | Oenothera Biennis Extract | Oenothera Biennis Extract is extracted from Oenothera biennis L., which has high anti-inflammatory properties. | ||
| E3853 | Blueberry Fruit Extract | Blueberry Fruit Extract is extracted from the fruits of Vaccinium, which helps in maintenance of blood sugar levels, reduction of oxidative stress, anti-inflammatory effect, prevention of cardiovascular diseases, antimicrobial and antitumoural activity. | ||
| E3854 | Coriolus Versicolor Extract | Coriolus Versicolor Extract is extracted from Coriolus versicolor, which possesses cytotoxic activity against cancer cells and endothelial cells and has the ability to inhibit the expression of the pro-tumorigenic factors associated with inflammation. | ||
| E3564 | Celery Extract | Celery Extract is extracted from Apium graveolens, which has suppressive effect on PMA/ionomycin mediated CD4+ T lymphocyte activation. | ||
| E3565 | Celery seed Extract | Celery Seed Extract is extracted from the seed of Apium graveolens, which has suppressive effect on PMA/ionomycin mediated CD4+ T lymphocyte activation. | ||
| S0947 | Cafestol | Cafestol is a natural diterpenes extracted from coffee beans. Cafestol induces apoptosis and regulates a variety of inflammatory mediators to reduce inflammation. Cafestol inhibits PI3K/Akt pathway. Cafestol also can reduce the production of ROS in the leukemia cell line HL60. | ||
| E3567 | Ash bark Extract | Ash Bark Extract is extracted from the bark of Fraxinus chinensis, which has anti-Inflammatory effect. | ||
| E3860 | Euphorbia Helioscopia Extract | Euphorbia Helioscopia Extract is extracted from Euphorbia helioscopia L., which has been used in the treatment of various diseases, including edema, phlegm and cough, malaria, dysentery, scab, tuberculous fistula, osteomyelitis, and cancer. | ||
| E3570 | Artemisia annua Extract | Artemisia Annua Extract is extracted from Artemisia Annua, which has antimalarial and anticancer effects. | ||
| E0365 | Fucoidan | Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc. |
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| E3188 | Cissus Quadrangularis Extract | Cissus Quadrangularis Extract is extracted from Cissus quadrangularis, which is used in the treatment of osteoporosis, asthma, haemorrhoids, and menstrual disorders. | ||
| E3867 | Fritillariae Thunbergii Bulbus Extract | Fritillariae Thunbergii Bulbus Extract is extracted from Fritillariae thunbergii bulbus, which is used to treat symptoms of cough and airway congestion in the chest due to pathological colds and damp phlegm. | ||
| E3875 | Unripe Bitter Orange Extract | Unripe Bitter Orange Extract is extracted from the bitter fruit of citrus unshiu, which is an effective anti-allergic functional food. | ||
| E3099 | Fritillaria Cirrhosa Seed Extract | Fritillaria Cirrhosa Seed Extract is extracted from the seeds of Fritillaria Cirrhosa, which is famous for its antitussive, expectorant, anti-asthma and anti-inflammatory properties, and is widely used to treat respiratory diseases. | ||
| E3878 | Stalactitum Extract | Stalactitum Extract is extracted from Stalactitum, which can be used as an anti-asthmatic. | ||
| E3879 | Glabrous Sarcandra Herb Extract | Glabrous Sarcandra Herb Extract is extracted from Sarcandra glabra (Thunb.), which has been applied to treat sore throats, abscesses, and even tumors. | ||
| S8091New | 25-Hydroxycholesterol | 25-Hydroxycholesterol is a side-chain oxysterol and a selective suppressor of IgA production by B cells with an EC50≈65 nM. It affects the immune system and has a key role in the pathogenesis of atherosclerosis. | ||
| E3890 | Lithospermum Erythrorhizon Extract | Lithospermum Erythrorhizon Extract is extracted from Lithospermum erythrorhizon, which has an anti-inflammatory response in bronchial epithelial cells. | ||
| E3892 | Viola Philphica Munda Extract | Viola Philphica Munda Extract is extracted from Viola philphica munda, which contains polysaccharide and anodyne (has pain-killing strength) and is a diuretic. | ||
| E3894 | Ardisia Japonica Extract | Ardisia Japonica Extract is extracted from Ardisia japonica, which is used in the treatment of coughs and to stop uterine bleeding. | ||
| E0022 | Ophiopogonin D | Ophiopogonin D (OJV-VI, Deacetylophiopogonin C) is a steroidal glycoside isolated from Chinese herb Radix ophiopogonis and shows anti-tumor property. Ophiopogonin D could suppress TGF-β1-mediated metastatic behavior of MDA-MB-231 cells by regulating ITGB1/FAK/Src/AKT/β-catenin/MMP-9 signaling axis. Ophiopogonin D attenuates PM2.5-induced inflammation via suppressing the AMPK/NF-κB pathway in mouse pulmonary epithelial cells. | ||
| E0020 | Lupenone | Lupenone (Lup-20(29)-en-3-one, lupeone) is an isolated compound exhibiting anti-oxidative, anti-inflammation, and anti-diabetic activities. Lupenone can protect SH-SY5y cells against METH-induced neuronal apoptosis through the PI3K/Akt pathway. | ||
| E3247 | Hainan Nightshade Fruit Extract | Hainan Nightshade Fruit Extract is extracted from the fruit of Hainan Nightshade, which has immunity-boosting powers and pain-eliminating abilities since it reduces inflammation and swelling in the body. | ||
| S3501 | Perflubron | Perflubron (1-Bromoperfluorooctane, Perfluorooctyl bromide, Oxygent, PFOB) exhibits anti-inflammatory activity thus decreases cytokine production in human alveolar macrophages. Perflubron also attenuates oxidative damage to both biological and nonbiological systems which is independent of its anti-inflammatory properties. | ||
| S3500 | Pentosan Polysulfate Sodium | Pentosan Polysulfate Sodium (PPS, Elmiron) is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also exhibits anti-HIV-1 activity. | ||
| E3898 | Radix Asteris Extract | Radix Asteris Extract is extracted from the root and rhizome of Aster tataricus L. f., which has been used to treat cough and asthma. | ||
| E3217 | Penthorum Chinense Pursh Extract | Penthorum Chinense Pursh Extract is extrcated from Penthorum Chinense Pursh, which is used in the treatment of traumatic injury, edema, and liver diseases. | ||
| E3283 | Red Bean Extract | Red Bean Extract is extracted from Red Beans, which possess various functional properties, such as anti-diabetes, anti-aging, anti-inflammatory, anticancer, and hepatoprotective activities. | ||
| E3358 | Rhizoma Fagopyri Dibotryis Extract | Rhizoma Fagopyri Dibotryis Extract is extracted from Rhizoma Fagopyri Dibotryis, which is used in the treatment of acute lung injury. | ||
| E3288 | Red Raspberry Extract | Red Raspberry Extract is extracted from Rubus idaeus, which is rich in bioactive components that plays a role in reduction oxidative stress. | ||
| E3289 | Knoxia Valerianoides Extract | Knoxia Valerianoides Extract is extracted from Knoxia Valerianoides, which along with other herbs can be used for detoxification and treating cancer and inflammatory diseases. | ||
| E3366 | Fineleaf Schizonepeta Herb Extract | Fineleaf Schizonepeta Herb Extract is extracted from the leaves of Schizonepeta, which is used as a traditional medicine with antipyretic, anti-inflammatory, analgesic, and hemostatic effects. | ||
| E3346 | Oriental Paperbush flower Extract | Oriental Paperbush flower Extract is extracted from the flowers of Edgeworthia chrysantha, which might serve as a potential drug for osteolytic diseases such as osteoporosis. | ||
| E3294 | Piper Nigrum Seed Extract | Piper Nigrum Seed Extract is extracted from Piper nigrum L., which has antimicrobial activity, antioxidant effects, antidiabetic activity, hypolipidemic activity, anti-inflammatory, analgesic, anticonvulsant, and neuroprotective effects. | ||
| E0119 | Iptacopan (LNP023) Hydrochloride | Iptacopan (LNP023) Hydrochloride is a first-in-class, orally administered, potent and highly selective factor B inhibitor with an IC50 of 12 nM and a Kd value of 7.9 nM. Iptacopan exhibits excellent selectivity over other proteases affording IC50s of >30 μM across a panel of 41 human proteases. | ||
| E3298 | Viscum Coloratum Extract | Viscum Coloratum Extract is extracted from Viscum Coloratum, which is used in the therapy of inflammatory diseases. | ||
| E3352 | Radix Tinosporae Extract | Radix Tinosporae Extract is extracted from Radix Tinosporae, which is a traditional Chinese medicine for the treatment of various inflammatory diseases. | ||
| E3574 | Cyclocarya paliurus Extract | Cyclocarya Paliurus Extract is extracted from Cyclocarya Paliurus, which has anti-fibrotic activity. | ||
| E3382 | Camu Camu fruit Extract | Camu Camu fruit Extract is extracted from the fruit of Myrciaria dubia McVaugh (Myrtaceae), which helps in preventing oxidative stress and skin inflammation induced by high glucose levels. | ||
| E3389 | Sophora alopecuroides seed Extract | Sophora Alopecuroides Seed Extract is extracted from the seeds of Sophora alopecuroides, which has anti-inflammatory activities. | ||
| S0836 | TMN355 | TMN355 (Compound 3i) is a potent inhibitor of cyclophilin A (CypA) with IC50 of 1.52 nM and reduces foam cell formation and cytokine secretion. TMN355 is used for the treatment of atherosclerosis. | ||
| S9064 | Trilobatin | Trilobatin (P-Phlorizin), a natural flavonoid lipid molecule, is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope and exihibits anti-oxidant and anti-inflammatory effect. | ||
| E3589 | Evodia Lepta Bark Extract | Evodia Lepta Bark Extract is extracted from the bark of Melicope pteleifolia, which has anti-inflammatory activity. | ||
| E1134 | ABR-238901 | ABR-238901 is a novel S100A8/A9 blocker that potently inhibits S100A8/A9 interaction with its receptors RAGE (receptor for advanced glycation endproducts) and TLR4 (toll-like receptor 4). | ||
| E1386 | KP-457 | KP-457 (TNF-α-converting enzyme) is a selective inhibitor of ADAM17 with IC50 of 11.1 nM/L (cell-free assay). It also cleaves various molecules such as GPIbα, GPV, and TNF-α. | ||
| S9072 | Sweroside | Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects. | ||
| E3596 | Phellinus linteus Extract | Phellinus Linteus Extract is extracted from Phellinus Linteus, which has immunomodulatory effect. | ||
| E3658 | Double coptis chinensis Extract | Double Coptis Chinensis Extract is extracted from Double Coptis Chinensis, which has antipyretic and anti-inflammatory mechanism. | ||
| E3578 | Fringed pink Extract | Fringed Pink Extract is extracted from Dianthus superbus, which has anti-inflammatory activity. | ||
| E3418 | Rhizoma Anemones Raddeanae Extract | Rhizoma Anemones Raddeanae Extract is extracted from the rhizome of Anemone raddeana Regel, which is used to treat wind and cold symptoms, hand-foot disease and spasms, joint pain, and ulcer pain. | ||
| S9090 | Corilagin | Corilagin, discovered in many medicinal plants such as Phyllanthus speices etc., has multiple activities including anti-oxidative, anti-inflammatory, anti-apoptotic, hepatoprotective and others. It is an inhibitor of TNF-α. | ||
| S4753 | Ganoderic acid A | Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities. | ||
| E3426 | Piper betle L. Extract | Piper Betle L. Extract is extracted from Piper betel l., which is a potential source of wound healing agents. | ||
| S9106 | Eleutheroside E | Eleutheroside E, a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory effects by inhibiting NF-κB and protecting against myocardial infarction. | ||
| E3440 | Tamarindus indica seed Extract | Tamarindus indica seed Extract is extracted from the seeds of Tamarindus indica, which helps to reduce inflammation and inflammation-induced cartilage degeneration. | ||
| E3149 | Pheretima Extract | Pheretima Extract is extracted from Pheretima, which has effects on various inflammatory diseases such as asthma, cough, and fever. | ||
| E3445 | Hibiscus sabdariffa flower Extract | Hibiscus sabdariffa flower Extract is extracted from the flowers of Hibiscus sabdariffa, which enhances anti-inflammatory effects by increasing expression of anti-inflammatory cytokines and decreasing pro-inflammatory cytokines. | ||
| E3446 | Chinese Starjasmine stem Extract | Chinese Starjasmine Stem Extract is extracted from the stem of Trachelospermum jasminoides, which is used in the treatment of inflammation-related diseases. | ||
| E3157 | Erycibes Caulis Extract | Erycibes Caulis Extract is extracted from Erycibes Caulis, which is used in the treatment of rheumatoid arthritis. | ||
| S3892 | Isopsoralen | Isopsoralen (Angelicin), also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses. | ||
| S9148 | Peiminine | Peiminine (Verticinone, Zhebeinone, Raddeanine), a biologically active component extracted from Fritillaria walujewii Regel, has been reported to have potent anti-inflammatory, antitussive, and expectorant effects. It induces autophagic cell death thus represses colorectal carcinoma tumor growth. | ||
| E3487 | Ecliptae Herba Extract | Ecliptae Herba Extract is extracted from Eclipta, which has an anti-osteoporotic effect. | ||
| S9920 | GYY4137 | GYY4137 is a novel, water-soluble hydrogen sulfide (H2S)–releasing molecule with vasodilator and antihypertensive activity. GYY4137 shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. GYY4137 also shows anti-inflammatory activity. | ||
| E3492 | Vitex negundo seed Extract | Vitex Negundo Seed Extract is extracted from the fruits of Vitex negundo, which is used in the treatment of rheumatism and joint inflammation. | ||
| E3494 | Oyster Shell Extract | Oyster Shell Extract is extracted from the shell of Ostreidae, which has an anti-inflammatory effect. | ||
| E0129 | Oxysophocarpine | Oxysophocarpine (OSC) is an alkaloid extracted from Sophora alopecuroides. Oxysophocarpine inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) by targeting the Nrf2/HO-1 axis. OSC protects cells against apoptosis and inflammatory responses and compromised miR-155 activity by attenuating MAPK and NF-κB pathways. | ||
| S5466 | Saikosaponin A | Saikosaponin A is a triterpene saponin derived from the medicinal plant, Bupleurum chinensis DC. (Umbelliferae). It has a variety of pharmacological benefits, including anti-inflammatory, immunomodulatory, and anti-bacterial activities. | ||
| E0131 | Luteolin-7-O-glucuronide | Luteolin-7-O-glucuronide (Luteolin 7-glucuronide) is a flavone glycoside found in plants. Luteolin-7-O-glucuronide possesses anti-microbial, antioxidant, anti-mutagenic, anti-genotoxic, anti-inflammatory, and anti-arthritic activities. |
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| E0226 | Chebulagic acid | Chebulagic acid, isolated form Terminalia chebula Retz, is a reversible and non-competitive inhibitor of maltase with a Ki value of 6.6 μM. Chebulagic acid shows potent anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. Chebulagic acid also shows potent COX–LOX dual inhibition activity with IC50 values of 15 μM, 0.92 μM and 2.1 μM for COX-1, COX-2 and 5-LOX respectively. |
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| E3476 | Myrrh Extract | Myrrh Extract is extracted from Commiphora myrrha, which is used in the therapy of inflammatory bowel diseases. | ||
| S5360 | Diflorasone | Diflorasone acts as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties. | ||
| S5412 | Loxoprofen Sodium | Loxoprofen sodium is a non-steroidal anti-inflammatory drug. | ||
| E0148 | Linalyl Acetate | Linalyl Acetate (Bergamiol, Bergamol, Linalool acetate) is a naturally occurring phytochemical found in many flowers and spice plants. Linalyl Acetate is a potentially anti-inflammatory agent. |
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| E0780 | MNITMT | MNITMT is a more potent immunosuppressive agent without bone marrow toxicity. | ||
| A2001 | Ipilimumab (anti-CTLA-4) | Ipilimumab (anti-CTLA-4) is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. MW : 148 kD. |
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| A2102 | Anti-mouse CD8α-InVivo | Anti-mouse CD8α (Clone:2.43)reacts with mouse CD8α. CD8 is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). It binds to class I MHC molecules displayed by antigen presenting cells (APC). |
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| A2009 | Rituximab (anti-CD20) | Rituximab (anti-CD20) is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM, MW: 143.86 KD. | ||
| A2028 | Tiragolumab (anti-TIGIT) | Tiragolumab (anti-TIGIT) (RG6058, MTIG7192A) is a humanized IgG1/kappa monoclonal antibody that binds TIGIT to prevent its interaction with its ligand PVR (CD155). | ||
| A2036 | Magrolimab (anti-CD47) | Magrolimab (anti-CD47) (5F9, GS-4721,Hu5F9 G4,ONO 7913) is a first-in-class macrophage immune checkpoint inhibitor that mainly binds to N-terminal pyroglutamate of CD47. |
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| A2037 | Sabatolimab (anti-TIM-3) | Sabatolimab (anti-TIM-3) (MBG453, NVP-MBG453) is a high-affinity, humanized IgG4 antibody targeting TIM-3 on the surface of T-cells. |
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| A2397 | Clivatuzumab (Anti-MUC1) | Clivatuzumab (Anti-MUC1) is a humanized anti-mucin monoclonal antibody targeting an epitope in the MUC1 antigen expressed in most pancreatic cancers. MW: 145.5 kD. | ||
| A2859 | Nurulimab (Anti-CTLA-4 / CD152) | Nurulimab (Anti-CTLA-4 / CD152) is a monoclonal antibody directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4, CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. MW: 145.34 KD. | ||
| A2860 | Zalifrelimab (Anti-CTLA-4 / CD152) | Zalifrelimab (Anti-CTLA-4 / CD152) is a recombinant human monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), with immune checkpoint inhibitory and antineoplastic activities. MW: 144.48 KD. | ||
| A2131 | Anti-mouse TIM-3 (CD366)-InVivo | Anti-mouse TIM-3 (CD366)-InVivo monoclonal antibody reacts with mouse TIM-3 (T cell immunoglobulin and mucin domain-3) also known as CD366. TIM-3 is specifically expressed at high levels on the surface of Th1 lymphocytes. This B8.2C12 antibody binds to the BALB/c allele of TIM-3 while reactivity to the C57Bl/6 allele. Inhibition of TIM-3 signaling in mice exacerbates experimental autoimmune encephalomyelitis and promotes IFNγ production and Th1 cell proliferation. | ||
| A2132 | Anti-mouse/human/rat CCL2 (MCP-1)-InVivo | Anti-mouse/human/rat CCL2 (MCP-1)-InVivo (Clone: 2H5) antibody reacts with mouse, human, and rat CCL2, also known as monocyte chemoattractant protein 1 (MCP-1). MCP-1 is a 13 kDa chemokine produced mainly by monocytes/macrophages and is a potent monocyte-attracting chemokine. The 2H5 antibody has been shown to neutralize the biological effects of CCL2 in vivo. | ||
| A2637 | Anti-CD47 (CC-90002) | Anti-CD47 (CC-90002) is a humanized monoclonal antibody (mAb) targeting CD47. It can be used for the research of hematologic malignancies and solid tumors. MW :150 KD. | ||
| A2939 | Ligelizumab (Anti-IgE) | Ligelizumab (anti-IgE) is a humanized high-affinity monoclonal anti-IgE antibody with the potential to be used in research on chronic spontaneous urticarial. MW: 146.6 KD. | ||
| A2940 | Talizumab (Anti-IgE) | Talizumab (anti-IgE) is a humanized monoclonal antibody against immunoglobulin E (IgE) with the potential to treat food allergies. MW: 146.56 KD. | ||
| A2103New | Anti-mouse CTLA-4 (CD152)-InVivo | Anti-mouse CTLA-4 (CD152) antibody (Clone:9H10) reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. Anti-mouse CTLA-4 (CD152) antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding. | ||
| A2104 | Anti-mouse CD3ε-InVivo | The 145-2C11 monoclonal antibody reacts with mouse CD3ε which is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. The 145-2C11 antibody has been shown to induce T lymphocyte activation, proliferation, and apoptosis in vitro via binding and stimulating the TCR. When used in vivo the antibody is reported to produce T cell activation, anergy, or death. | ||
| A2114New | Anti-mouse NK1.1-InVivo | The PK136 monoclonal antibody(Clone: PK136) reacts with mouse NK1.1 also known as CD161b/CD161c, KLRB1, NKR-P1A and Ly-55. |
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| A2108 | Anti-mouse CD28-InVivo | The PV-1 monoclonal antibody(Clone: PV-1) reacts with mouse CD28.The PV-1 antibody has been shown to stimulate the proliferation and cytokine production by activated T and NK cells. | ||
| A2110 | Anti-mouse CD16/CD32-InVivo | The 2.4G2 monoclonal antibody (Clone: 2.4G2)reacts specifically with mouse CD16 (FcγRIII) and CD32 (FcγRII). It has also been reported to react non-specifically via its Fc domain to FcγRI. The 2.4G2 antibody is commonly used in flow cytometry staining experiments to prevent non-specific binding of IgG to the FcγIII and FcγII, and possibly FcγI, receptors prior to staining with antigen specific primary antibodies. |
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| A2111New | Anti-human CD3-InVivo | The OKT-3 monoclonal antibody reacts with human CD3ε which is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily.The OKT-3 antibody has immunosuppressive properties in vivo and has been shown to effectively treat renal, heart and liver allograft rejection. | ||
| A2112 | Anti-mouse CD40L (CD154)-InVivo | The MR-1 monoclonal antibody reacts with mouse CD154 also known as CD40 ligand. The MR-1 monoclonal antibody has been reported to inhibit in vitro activation of B lymphocytes by blocking the binding of CD154 with CD40 on T helper cells as well as inhibit the formation of germinal centers and disrupt antigen-specific T cell responses. Additionally, the MR-1 antibody blocks interactions of T cells and antigen-presenting cells in vitro and blocks the development of experimental autoimmune disease in vivo. | ||
| A2970 | Ociperlimab (Anti-TIGIT) | Ociperlimab (anti-TIGIT) is a humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting the co-inhibitory molecule and immune checkpoint inhibitor T-cell immunoreceptor with immunoglobulin (Ig) and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT), with potential immune checkpoint inhibitory activity. MW: 145.12 kD. | ||
| A2033 | Vibostolimab (anti-TIGIT) | Vibostolimab (anti-TIGIT, MK-7684) is a humanized monoclonal antibody that binds to the T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT), blocking the interaction between TIGIT and its ligands, CD112 and CD155, thereby activating T lymphocytes which help to destroy tumor cells. | ||
| A2571 | Anti-CCL5 / RANTES | Anti-CCL5 / RANTES (NI-0701) is a antibody tageting CCL5. MW:145.5 KD. | ||
| A2573 | Carlumab (Anti-CCL2 / MCP1) | Carlumab (Anti-CCL2 / MCP1) is a humanised monoclonal antibody targeting CCL2 with high affinity. Carlumab can be used in cancer research, particularly in prostate cancer. MW:145.5 KD. | ||
| A2044 | Omalizumab (anti-IgE) | Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) with a KD of 0.393 nM. Omalizumab binds to the human FcγRIIb receptors with a KD of 6.37 uM. Omalizumab has the potential for persistent allergic asthma research. | ||
| A2802 | Cobolimab (Anti-TIM-3 / HAVCR2 / CD366) | Cobolimab (Anti-TIM-3 / HAVCR2 / CD366) is a monoclonal antibody against the inhibitory T-cell receptor, T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3; TIM3; hepatitis A virus cellular receptor 2; HAVCR2), with potential immune checkpoint inhibitory and antineoplastic activities. MW : 142.84 KD. | ||
| E3702 | Eupolyphage sinensis Walker Extract | Eupolyphage sinensis Walker Extract is aqquired from the aqueous extract of Eupolyphaga sinensis Walker, which shows a potency to potentiate immune responses in mice. | ||
| S1829 | Pranlukast | Pranlukast (ONO-1078,ono-rs-411) is an orally administered, and selective antagonist of the cysteinyl leukotrienes (LT) C(4), LTD(4) and LTE(4), used in the prophylactic treatment of chronic bronchial asthma. | ||
| E1777New | RIG012 | RIG012 is a potent antagonist of Retinoic Acid Inducible Gene 1 (RIG-I), an innate immune receptor, with an IC50 of 0.71 μM in the NADH-coupled ATPase assay. It effectively blocks RIG-I-initiated signaling and inflammatory responses induced by SARS-CoV-2 RNA. | ||
| S4529 | Idramantone | Idramantone (Kemantane, 5-Hydroxy-2-adamantanone) is an immune agonist. | ||
| S4709 | Latanoprost | Latanoprost (Xalatan, PhXA41) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure. | ||
| S1737 | Prednisolone | Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. |
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| S3648 | Amlexanox | Amlexanox is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε. | ||
| S8301 | Ossirene (AS101) | Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme. | ||
| S8760 | Iberdomide (CC220) | Iberdomide (CC-220) is a novel oral immunomodulatory compound that targets cereblon, part of the CRL4CRBN E3 ubiquitin ligase complex, with an IC50 of 60 nM in a competitive TR-FRET assay. Iberdomide (CC-220) induces apoptosis with antitumor and immunostimulatory activities. | ||
| S7892 | Avadomide (CC-122) | Avadomide (CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN. | ||
| S7516 | Y-320 | Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM. | ||
| S1733 | Methylprednisolone | Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. |
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| S2787 | Laquinimod | Laquinimod (ABR-215062, LAQ) is a potent immunomodulator. Phase 3. | ||
| S7515 | VGX-1027 | VGX-1027 (GIT 27) is an orally active immunomodulator. Phase 1. | ||
| S3668 | Thymopentin | Thymopentin (TP5) has immuno-regulatory activities. The immuno-regulatory actions of thymopentin on peripheral T cells are mediated by intracellular cyclic GMP elevations in contrast to the intracellular cyclic AMP elevations induced in precursor T cells that trigger their further differentiation to T cells. | ||
| S5083 | Lentinan | Lentinan (A823605, Bromoduline), isolated and purified from a hot water extract of Lentinula edodes fruit bodies, is a fungal polysaccharide immunomodulator with anti-tumor effects. | ||
| S4842 | Balsalazide | Balsalazide (Colazal, Giazo), an aminosalicylate and oral prodrug, is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway. | ||
| E3816 | Emilia Sonchifolia Extract | Emilia Sonchifolia Extract is extracted from Emilia sonchifolia, which is a potent immune response modulator. | ||
| E3527 | Glossy privet fruit Extract | Glossy Privet Fruit Extract is extracted from the fruits of Ligustrum lucidum, which has immunomodulatory effects. | ||
| E3821 | Alpinia Oxyphyllae Extract | Alpinia Oxyphyllae Extract is extracted from Alpinia oxyphyllae, which has potent activities in modulating multiple signaling pathways associated with β-amyloid deposition, tau protein phosphorylation, chronic inflammation, oxidative stress. | ||
| E3540 | Grapefruit Extract | Grapefruit Extract is extracted from Citrus paradisi Macf., which can serve as immune modulators in the intestine and maintain intestinal macrophage homeostasis. | ||
| E4972New | Efaproxiral | Efaproxiral(RSR13) is a synthetic allosteric modifier of haemoglobin that reduces its oxygen binding affinity, facilitating oxygen release. This increases the whole blood P50 and tissue partial pressure of oxygen (Po2), enhancing oxygen delivery to tissues and improving oxygenation in hypoxic tumors. | ||
| E3082 | Bupleurum Extract | Bupleurum Extract is extracted from Bupleurum, which has been used in the treatment of inflammation. | ||
| S5973 | Methylprednisolone Acetate | Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. | ||
| E3270 | Black Rice Extract | Blackberry Extract is extracted from Rubus fruticosus, which has both anti-inflammatory and pro-inflammatory properties. | ||
| S5969 | Dicloxacillin Sodium hydrate | Dicloxacillin Sodium hydrate (DLX, Dycill, Dynapen, Pathocil), a narrow-spectrum β-Lactam antibiotic of the penicillin class, induces drug-metabolizing CYP enzymes to a clinically relevant extent. | ||
| S2307 | Roquinimex | Roquinimex (FCF 89, Linomide, LS 2616) is a novel immunomodulator augmenting natural killer (NK) cell activity and T-lymphocyte related effector functions. Roquinimex is a potent oral active tumor antiangiogenic agent. Roquinimex inhibits the secretion of TNF-α. | ||
| E4972New | Efaproxiral | Efaproxiral(RSR13) is a synthetic allosteric modifier of haemoglobin that reduces its oxygen binding affinity, facilitating oxygen release. This increases the whole blood P50 and tissue partial pressure of oxygen (Po2), enhancing oxygen delivery to tissues and improving oxygenation in hypoxic tumors. | ||
| S8091New | 25-Hydroxycholesterol | 25-Hydroxycholesterol is a side-chain oxysterol and a selective suppressor of IgA production by B cells with an EC50≈65 nM. It affects the immune system and has a key role in the pathogenesis of atherosclerosis. | ||
| E1777New | RIG012 | RIG012 is a potent antagonist of Retinoic Acid Inducible Gene 1 (RIG-I), an innate immune receptor, with an IC50 of 0.71 μM in the NADH-coupled ATPase assay. It effectively blocks RIG-I-initiated signaling and inflammatory responses induced by SARS-CoV-2 RNA. | ||
| E4868New | Olsalazine | Olsalazine is a salicylic acid-derived anti-inflammatory agent used to treat ulcerative colitis. | ||
| A2103New | Anti-mouse CTLA-4 (CD152)-InVivo | Anti-mouse CTLA-4 (CD152) antibody (Clone:9H10) reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. Anti-mouse CTLA-4 (CD152) antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding. | ||
| A2114New | Anti-mouse NK1.1-InVivo | The PK136 monoclonal antibody(Clone: PK136) reacts with mouse NK1.1 also known as CD161b/CD161c, KLRB1, NKR-P1A and Ly-55. |
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| A2111New | Anti-human CD3-InVivo | The OKT-3 monoclonal antibody reacts with human CD3ε which is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily.The OKT-3 antibody has immunosuppressive properties in vivo and has been shown to effectively treat renal, heart and liver allograft rejection. | ||
| E4964New | ATP (disodium trihydrate) | ATP disodium trihydrate, is the primary energy currency of the cell, essential for intracellular energy metabolism. It regulates extracellular biological processes, including cardiac function, neurotransmission, muscle contraction, vasodilation, bone and liver glycogen metabolism, and inflammation. It also plays a crucial role in initiating immune responses during infections. |
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