Home Immunology & Inflammation Immunology & Inflammation related chemical Tempol For research use only.

Tempol

Synonyms: 4-Hydroxy-TEMPO

Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.

Tempol Chemical Structure

Tempol Chemical Structure

CAS No. 2226-96-2

Purity & Quality Control

Tempol Related Products

Biological Activity

Description Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.
In vitro
In vitro Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage. [1] Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. [2]
Cell Research Cell lines HL60
Concentrations 0.05–1.6 mM
Incubation Time 96 h
Method The antiproliferative effect of Tempol is assessed by the MTT assay after 96 h exposure of the cells to the drug. Briefly, 100,000 cells/mL are seeded onto 96-well plates and allowed to grow for 24 h before treatment with different concentrations of Tempol (0.05–1.6 mM).
In Vivo
In vivo Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat. [3] Tempol prevents cerebral vessel remodeling in hypertensive rats. [4] Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. [5] Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats. [6]
Animal Research Animal Models Male Wistar rats
Dosages 30 mg/kg
Administration bolus injection
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04729595 Terminated
Covid19
Adamis Pharmaceuticals Corporation
 September 1 2021 Phase 2|Phase 3

Chemical Information & Solubility

Molecular Weight 172.24 Formula

C9H18NO2
CAS No. 2226-96-2 SDF Download Tempol SDF
Smiles CC1(CC(CC(N1[O])(C)C)O)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 35 mg/mL ( (203.2 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 35 mg/mL

Ethanol : 35 mg/mL


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In vivo
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