Home Immunology & Inflammation Immunology & Inflammation related chemical CORM-3 For research use only.

CORM-3

CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.

CORM-3 Chemical Structure

CORM-3 Chemical Structure

CAS No. 475473-26-8

Purity & Quality Control

CORM-3 Related Products

Biological Activity

Description CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
In vitro
In vitro CORM-3 protects against hypoxia-reoxygenation and oxidative stress by promoting CO release in cardiac cells. [1] CORM-3 attenuates the inflammatory response induced by LPS in RAW264.7 murine macrophages. [2] CORM-3 also uncouples mitochondrial respiration via interaction with the phosphate carrier. [4]
In Vivo
In vivo CORM-3 (40 mg/kg i.p.) prolongs the survival of murine cardiac grafts and attenuates organ rejection in CBA mice transplanted with BALB/c hearts. [1] CORM-3 (20 mg/kg i.p.) decreases cellular infiltration, joint inflammation and destruction in a collagen-induced arthritis mouse model. [3]
Animal Research Animal Models CBA mice transplanted with BALB/c hearts.
Dosages ~40 mg/kg daily
Administration i.p.

Chemical Information & Solubility

Molecular Weight 294.61 Formula

C5 H4 Cl N O5 Ru
CAS No. 475473-26-8 SDF Download CORM-3 SDF
Smiles [CH+]=O.[CH+]=O.[CH+]=O.C(C(=O)O)[NH-].Cl[Ru]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 58 mg/mL ( (196.87 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 50 mg/mL

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy CORM-3 | CORM-3 supplier | purchase CORM-3 | CORM-3 cost | CORM-3 manufacturer | order CORM-3 | CORM-3 distributor