Home Immunology & Inflammation Immunology & Inflammation related chemical Thymol For research use only.

Thymol

Synonyms: 2-isopropyl-5-methylphenol, IPMP

Thymol (2-isopropyl-5-methylphenol, IPMP), a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro.

Thymol Chemical Structure

Thymol Chemical Structure

CAS No. 89-83-8

Purity & Quality Control

Batch: S515701 DMSO]30 mg/mL]false]]]false]]]false Purity: 99.94%
99.94

Thymol Related Products

Biological Activity

Description Thymol (2-isopropyl-5-methylphenol, IPMP), a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro.
In vitro
In vitro Thymol inhibits LPS-induced TNF-α, IL-6 and IL-1β production in BALF. Furthermore, thymol significantly reduces the MPO activity, MDA content, lung wet/dry weight ratio and histopathological changes induced by LPS. In addition, thymol inhibits LPS-induced NF-κB signaling pathway and up-regulates the expression of Nrf2 and HO-1[1].
In Vivo
In vivo Thymol has been reported to protect mice against high-fat diet (HFD) induced type 2 diabetes. Thymol alleviates LPS-induced lung inflammation in mice[1].
Animal Research Animal Models Male BALB/c mice
Dosages 20, 40, 80 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02202304 Withdrawn
Periodontal Disease|Caries
Rosa Moreno Lopez|Ivoclar Vivadent AG|University of Aberdeen
 September 10 2017 Phase 4

Chemical Information & Solubility

Molecular Weight 150.22 Formula

C10H14O
CAS No. 89-83-8 SDF Download Thymol SDF
Smiles CC1=CC(=C(C=C1)C(C)C)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 30 mg/mL ( (199.7 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Thymol | Thymol supplier | purchase Thymol | Thymol cost | Thymol manufacturer | order Thymol | Thymol distributor