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Coumarin

Name: Coumarin
Brand: Selleck Chemicals
SKU: S4170
Rating: 5 (1 reviews)

Catalog No.S4170 Purity:99.97%

Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.

Coumarin Chemical Structure

CAS No. 91-64-5

Purity & Quality Control

Batch: S417001 DMSO]29 mg/mL]false]Ethanol]29 mg/mL]false]Water]Insoluble]false Purity: 99.97%

99.97

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Biological Activity

Description	Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.

In vitro
In vitro	Coumarin is a fragrant organic chemical compound in the benzopyrone chemical class, which is a colorless crystalline substance in its standard state. Coumarin is a naturally occurring constituent of many plants and essential oils, including tonka beans, sweet clover, woodruff, oil of cassia, and lavender. Coumarin is a member of a class of compounds called benzopyrones. Coumarin compounds have been used to treat such diverse ailments as cancer, bums, brucellosis, and rheumatic disease, and they have been used as antispasmodics. Although coumarin itself has no anticoagulant properties, it is transformed into the natural anticoagulant dicoumarol by a number of species of fungi. This occurs as the result of the production of 4-hydroxycoumarin, then further into the actual anticoagulant dicoumarol, a fermentation product and mycotoxin. This substance is responsible for the bleeding disease known historically as "sweet clover disease" in cattle eating moldy sweet clover silage.^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT04952792	Completed	Atrial Fibrillation\|Hemodialysis Complication	Hospital Universitari de Bellvitge\|Spanish Society of Nephrology\|Baxter Healthcare Corporation	May 20 2021	Phase 2
NCT01119300	Completed	Venous Thromboembolism\|Atrial Fibrillation	Utrecht Institute for Pharmaceutical Sciences\|Utrecht University\|Leiden University Medical Center\|Erasmus Medical Center\|University of Ulm\|Newcastle University\|University of Liverpool\|LGC Limited\|Uppsala University\|Democritus University of Thrace\|Elisabethinen Hospital	January 2011	Phase 4
NCT00157118	Completed	Protein C Deficiency	Baxalta now part of Shire\|Takeda	August 22 2003	Phase 2\|Phase 3

References

[1] Egan D, et al. Drug Metab Rev, 1990, 22(5), 503-529.

Chemical Information & Solubility

Molecular Weight	146.14	Formula	C₉H₆O₂
CAS No.	91-64-5	SDF	Download Coumarin SDF
Smiles	C1=CC=C2C(=C1)C=CC(=O)O2
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 29 mg/mL ( (198.43 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 29 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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