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ATP

Name: ATP
Brand: Selleck Chemicals
SKU: S5260
Rating: 5 (6 reviews)

Synonyms: Adenosine-Triphosphate, Adenosine 5'-triphosphate

Catalog No.S5260 Purity:99.98%

ATP (Adenosine-Triphosphate, Adenosine 5'-triphosphate) is a multifunctional nucleoside triphosphate and an important endogenous signaling molecule in immunity and inflammation.

ATP Chemical Structure

CAS No. 56-65-5

Purity & Quality Control

Batch: Purity: 99.98%

99.98

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Biological Activity

Description	ATP (Adenosine-Triphosphate, Adenosine 5'-triphosphate) is a multifunctional nucleoside triphosphate and an important endogenous signaling molecule in immunity and inflammation.

In vitro
In vitro	ATP, a multifunctional nucleoside triphosphate and an important endogenous signaling molecule, restores signaling responses to anti-TCR treatment in Jurkat cells.^[2]
Cell Research	Cell lines	Jurkat cells
	Concentrations	50 mM
	Incubation Time	--
	Method	Cells are washed with calcium-free and magnesium-free 1×DPBS to remove calcium and magnesium. Then cells are suspended with 450 µL 1×DPBS into a 1.5 mL centrifugal tube, treated with 50 mL Streptolysin O (0.5 µg/ml), and incubated 60 mins at 37℃. Next, cells are centrifuged at 400 g for 4 mins to discard the supernatant. Cells are re-suspended with 100 mL 1×DPBS, treated with 11 µL 50 mM ATP, and incubated in the 37℃ for indicated time.

In Vivo
In vivo	ATP can activate the NLRP3 inflammasome and enhance the production of pro-inflammatory cytokines, thus protecting mice against bacterial infection.^[3]
Animal Research	Animal Models	Kunming mice
	Dosages	50 mg/kg
	Administration	i.p.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT04760860	Not yet recruiting	Dementia With Lewy Bodies	Qiang Zhang\|University of Iowa	October 2024	Phase 1\|Phase 2
NCT05590195	Not yet recruiting	Bacterial Vaginosis\|Bacterial Infections\|Bacterial Vaginosis \| Vaginal \| Microbiology\|Vaginal Infection	Jeremy Burton\|Deerland Enzymes\|Lawson Health Research Institute\|St. Joseph''s Health Care London	May 1 2024	Phase 3
NCT06167512	Not yet recruiting	Multi-organ Failure After Severe Trauma	Assistance Publique - Hôpitaux de Paris	April 1 2024	--

References

Chemical Information & Solubility

Molecular Weight	507.18	Formula	C₁₀H₁₆N₅O₁₃P₃
CAS No.	56-65-5	SDF	--
Smiles	NC1=C2N=C[N](C3OC(CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)C(O)C3O)C2=NC=N1
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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