Thymol

Catalog No.S5157 Batch:S515701

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Technical Data

Formula

C10H14O
Molecular Weight 150.22 CAS No. 89-83-8
Solubility (25°C)* In vitro DMSO 30 mg/mL (199.7 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Thymol (2-isopropyl-5-methylphenol, IPMP), a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro.
In vitro Thymol inhibits LPS-induced TNF-α, IL-6 and IL-1β production in BALF. Furthermore, thymol significantly reduces the MPO activity, MDA content, lung wet/dry weight ratio and histopathological changes induced by LPS. In addition, thymol inhibits LPS-induced NF-κB signaling pathway and up-regulates the expression of Nrf2 and HO-1[1].
In vivo Thymol has been reported to protect mice against high-fat diet (HFD) induced type 2 diabetes. Thymol alleviates LPS-induced lung inflammation in mice[1].

Protocol (from reference)

Animal Study:

[1]
  • Animal Models

    Male BALB/c mice

  • Dosages

    20, 40, 80 mg/kg

  • Administration

    i.p.

Selleck's Thymol has been cited by 1 publication

Thymol Ameliorates Aspergillus fumigatus Keratitis by Downregulating the TLR4/ MyD88/ NF-kB/ IL-1β Signal Expression and Reducing Necroptosis and Pyroptosis [ J Microbiol Biotechnol, 2023, 33(1):43-50] PubMed: 36517045

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.