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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

LPA Receptor

In vitro pharmacological characterization of standard and new lysophosphatidic acid receptor antagonists using dynamic mass redistribution assay

142 views | Jan 19 2024

The use of label-free dynamic mass redistribution assays revealed novel LPA1 inverse agonist CHI and highlighted the potential advantages over traditional calcium mobilization assays in characterizing LPA receptor ligands for diverse therapeutic applications. [Read the Full Post]

LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability

104 views | Jan 05 2024

The upregulation of LIPH in pancreatic ductal adenocarcinoma drives tumor progression by activating the LPA/LPAR axis, promoting aberrant glycolysis, and maintaining ALDOA stability, offering a potential avenue for a targeted gemcitabine-based combination therapy with limited side effects. [Read the Full Post]

Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis

150 views | Jul 30 2023

Targeting the LPA-LPAR1 axis shows promise as a therapeutic intervention for advanced osteosarcoma by inhibiting invasion and metastasis of the cancer cells. [Read the Full Post]

TXA2 mediates LPA1-stimulated uterine contraction in late pregnant mouse

81 views | May 09 2023

LPA1 stimulation induces contractions in late pregnant mouse uterus through the TXA2 pathway and may have clinical applications in inducing labor in uterine dysfunctions/dystocia. [Read the Full Post]

Potentiation of ASIC currents by lysophosphatidic acid in rat dorsal root ganglion neurons

106 views | Apr 11 2023

LPA enhances ASIC-mediated electrophysiological activity and nociception via a LPA1 receptor and PKC signaling pathway, providing a novel peripheral mechanism underlying pain sensitization. [Read the Full Post]

Lysophosphatidic acid upregulates connective tissue growth factor expression in osteoblasts through the GPCR/PKC and PKA pathways

1085 views | Jun 17 2018

Yu ZL et al. indicated that LPA increases CCN2 expression through the activation of PKC and PKA. Thus, the regulatory functions of the PKC and PKA pathways are implicated in the LPA-induced increase in CCN2 expression. [Read the Full Post]

Both genetic deletion and pharmacological blockade of lysophosphatidic acid LPA1 receptor results in increased alcohol consumption

896 views | Jun 17 2018

Castilla-Ortega E et al. suggested a relevant role for the LPA/LPA1 signaling system in alcoholism. In addition, the LPA1-null mice emerge as a new model for genetic vulnerability to excessive alcohol drinking. The pharmacological manipulation of LPA1 receptor arises as a new target for the study and treatment of alcoholism. [Read the Full Post]

Modulation of Nav1.8 by Lysophosphatidic Acid in the Induction of Bone Cancer Pain

880 views | Apr 26 2018

Pan HL et al. demonstrated the modulation of Nav1.8 by LPA in DRG neurons, and that this probably underlies the peripheral mechanism by which bone cancer pain is induced. [Read the Full Post]