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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

cAMP

Inhibition of exchange proteins directly activated by cAMP as a strategy for broad-spectrum antiviral development

101 views | Nov 14 2023

The study demonstrates that EPAC antagonists like ESI-09 hold promise as broad-spectrum antiviral therapies, offering robust protection against various viruses and potential contributions to pandemic preparedness. [Read the Full Post]

Pituitary Adenylate Cyclase Activating Polypeptide Inhibits A10 Dopamine Neurons and Suppresses the Binge-like Consumption of Palatable Food

138 views | Oct 19 2023

Pituitary adenylate cyclase-activating polypeptide (PACAP) activates PAC1 receptors and KATP channels to inhibit A10 dopamine neurons in the ventral tegmental area (VTA), resulting in a sex-dependent suppression of binge-like consumption and contributing to the regulation of energy homeostasis through the hedonic energy balance circuitry. [Read the Full Post]

Platelet zinc status regulates prostaglandin-induced signaling, altering thrombus formation

127 views | Oct 18 2023

Zinc chelation potentiates platelet prostacyclin (PGI2) signaling, resulting in increased inhibition of platelet activation, aggregation, and thrombus formation. [Read the Full Post]

The protective effects of NE 52-QQ57 against interleukin-33-induced inflammatory response in activated synovial mast cells

595 views | Oct 09 2023

The study suggests that inhibiting GPR4 signaling with the antagonist NE 52-QQ57 may have therapeutic benefits in rheumatoid arthritis by reducing inflammatory responses and oxidative stress in synovial mast cells. [Read the Full Post]

DEHP Decreases Steroidogenesis through the cAMP and ERK1/2 Signaling Pathways in FSH-Stimulated Human Granulosa Cells

234 views | Mar 23 2023

DEHP inhibits the cAMP and ERK1/2 signaling pathways, leading to the inhibition of steroidogenesis in FSH-stimulated hCGC. [Read the Full Post]

The Effects of PI3K/Akt/mTOR Signaling Pathway Inhibitors on the Expression of Immune Checkpoint Ligands in Acute Myeloid Leukemia Cell Line

300 views | May 04 2022

Saeid Taghiloo et al. found that combinational treatment approaches to block these pathways might be a promising and novel therapeutic strategy for AML patients via interfering in immune escape mechanisms. [Read the Full Post]

The Tumor Microenvironment in Follicular Lymphoma: Its Pro-Malignancy Role with Therapeutic Potential

677 views | Jun 10 2021

Takashi Watanabe found that Tfh, and TFR cells could reinforce the effects of the cytotoxic T cells. [Read the Full Post]

The microRNA-7-mediated reduction in EPAC-1 contributes to vascular endothelial permeability and eNOS uncoupling in murine experimental retinopathy

548 views | Mar 16 2019

Garcia-Morales V et al. indicated that EPAC-1 resembles an efficacious and druggable target molecule for the amelioration of (diabetic) retinopathy. [Read the Full Post]

Nano-emulsions as vehicles for topical delivery of forskolin

699 views | Feb 14 2019

Miastkowska M et al. showed that the nano-emulsions developed in this study could be used as effective carriers for topical administration of forskolin. [Read the Full Post]

Cannabinoid receptor-2 stimulation suppresses neuroinflammation by regulating microglial M1/M2 polarization through the cAMP/PKA pathway in an experimental GMH rat model.

0 views | Oct 06 2017

Tao Y et al. proposed that promotion of microglial M2 polarization through the cAMP/PKA pathway participates in the CB2R-mediated anti-inflammatory effects after GMH induction. [Read the Full Post]