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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

IRE1

Metastatic effects of environmental carcinogens mediated by MAPK and UPR pathways with an in vivo Drosophila Model

77 views | Aug 18 2023

This study revealed that exposure to environmental carcinogens (PCB126, PFOA, and CdCl2) increased tumor invasion rates, disrupted larval body weight and locomotion behavior, and influenced the expression of genes in the MAPK and UPR pathways, with the sna/E-cad pathway playing a crucial role in connecting the effects of these carcinogens on UPR and MAPK regulations and the resultant metastasis. [Read the Full Post]

DHA induces adipocyte lipolysis through endoplasmic reticulum stress and the cAMP/PKA signaling pathway in grass carp ( Ctenopharyngodon idella)

151 views | Jun 27 2023

The study demonstrated that supplementation of docosahexaenoic acid (DHA) in grass carp induced lipolysis by evoking endoplasmic reticulum (ER) stress, activating the cAMP/PKA signaling pathway, and involving components of the unfolded protein response, providing insights into mitigating lipid accumulation in fish through DHA targeting. [Read the Full Post]

Crosstalk between activating transcription factor 6 and the inositol-requiring enzyme 1-X-box binding protein 1 pathway in oxygen-glucose deprivation/reoxygenation-injured HT22 cells

88 views | Jun 01 2023

The study investigated the crosstalk between the ATF6 and IRE1-XBP1 pathways in OGD/R-injured HT22 cells and found that activation of ATF6 inhibited the mRNA expression of XBP1s and XBP1u without affecting their downstream transcriptional response, while inhibition of IRE1 had no significant effect on the examined parameters. [Read the Full Post]

Complexity in radiological morphology predicts worse prognosis and is associated with an increase in proteasome component levels in clear cell renal cell carcinoma

256 views | Jan 04 2023

Kohei Kobatake et al. thought that investigating RM on pre-treatment CT scans could effectively predict worse prognosis. [Read the Full Post]

Utilizing inner filter effect in resonance Rayleigh scattering technique: a case study with silver nanocubes as RRS probe and several analytes as absorbers

210 views | Jan 04 2023

Rasoul Gheitaran et al. found that the newly developed IFE mechanism could be employed as an attractive and highly efficient analytical technique for measuring different analytes. [Read the Full Post]