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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Fungal

Phase 1b safety and pharmacokinetics of intravenous and oral fosmanogepix in patients with acute myeloid leukaemia and neutropenia

128 views | Dec 13 2023

**In this Phase 1b study, fosmanogepix, administered intravenously and orally to acute myeloid leukemia patients with neutropenia undergoing chemotherapy, demonstrated excellent tolerability, with no serious adverse events, and exhibited consistent pharmacokinetic profiles, supporting its potential as a safe and effective antifungal treatment option.** [Read the Full Post]

Efficient production of recombinant proteins in suspension CHO cells culture using the Tol2 transposon system coupled with cycloheximide resistance selection

168 views | May 16 2023

The study demonstrates an efficient method for producing therapeutic proteins using DNA recombination techniques in mammalian cells, combining the Tol2 transposon system and cell selection by cycloheximide resistance to produce stable cell lines with constant productivity and cell growth suitable for commercial production. [Read the Full Post]

Plasma and Cerebrospinal Fluid Concentrations of Micafungin Administered at High Doses in Critically Ill Infants with Systemic Candidiasis: A Pooled Analysis of Two Studies

197 views | Apr 25 2023

The pharmacokinetics of micafungin were analyzed in 53 neonates with systemic candidiasis, revealing that neonates may require higher doses of micafungin than adults to reach therapeutic levels, and micafungin crosses the blood-brain barrier reaching therapeutic levels in CSF with doses ranging between 8 and 15 mg/kg/day. [Read the Full Post]

Comparison of in vitro Susceptibilities of Talaromyces marneffei in Mold and Yeast Forms in Malaysia

119 views | Apr 25 2023

The study found that the susceptibility of T. marneffei to most antifungal drugs was similar for both yeast and mold forms, except for caspofungin and micafungin, which had significant differences in GM MIC. [Read the Full Post]

PK/PD modeling and simulation of the in vitro activity of the combinations of isavuconazole with echinocandins against Candida auris

173 views | Apr 24 2023

The study used a pharmacokinetic/pharmacodynamic modeling and simulation approach based on in vitro data to predict the in vivo response to combination therapy against Candida auris, highlighting the importance of bridging in vitro results to the clinic. [Read the Full Post]

Toxicity interactions of azole fungicide mixtures on Chlorella pyrenoidosa

199 views | Apr 23 2023

The study investigated the combined toxicities and toxic interactions of 225 binary mixtures and 126 multi-component mixtures of 10 azole fungicides on Chlorella pyrenoidosa, finding that the toxicity interactions at low concentrations are dominated by additive effects, while at high concentrations, both synergistic and antagonistic effects are observed, with epoxiconazole inducing synergistic effects and clotrimazole inducing antagonistic effects. [Read the Full Post]

Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations

107 views | Apr 16 2023

The study found that Candida auris isolates with FKS1 mutations were resistant to echinocandins in vivo, including micafungin and caspofungin, and that mutations in R1354 resulted in in vivo resistance despite remaining below the micafungin breakpoint in vitro. [Read the Full Post]

Low level of antifungal resistance in Candida species recovered from Iranian HIV-associated oral infection

107 views | Apr 16 2023

The study found a high prevalence of oral candidiasis among PLWHA following HAART, and highlighted the need to understand the mechanisms of reduced susceptibility and low-level resistance in Candida species and consider local epidemiology in their management. [Read the Full Post]

Surface-Functionalized Metal-Organic Frameworks for Binding Coronavirus Proteins

153 views | Mar 11 2023

The research proposes using metal-organic frameworks (MOFs) functionalized with repurposed antiviral agents to selectively bind and deactivate respiratory coronaviruses, highlighting their potential in combating future pandemics. [Read the Full Post]

Alginate oligosaccharides enhance the antifungal activity of nystatin against candidal biofilms

236 views | Mar 11 2023

The study demonstrates the potential clinical utility of OligoG in conjunction with nystatin against Candida spp. in the prevention and topical treatment of candidal biofilm infections. [Read the Full Post]