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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

IDO/TDO

Liquid chromatography-tandem mass spectrometry based simultaneous quantification of tryptophan, serotonin and kynurenine pathway metabolites in tissues and cell culture systems

186 views | Jan 05 2024

This groundbreaking UPLC-MS/MS method for quantifying kynurenine-related metabolites holds immense promise in unraveling intricate disease pathways and could pave the way for targeted therapeutic interventions. [Read the Full Post]

Indoximod-based chemo-immunotherapy for pediatric brain tumors: a first-in-children phase 1 trial

178 views | Dec 12 2023

The Phase 1 trial of indoximod, an IDO-pathway inhibitor, in combination with chemotherapy and radiation, demonstrated favorable tolerability, significant objective responses, and encouraging immune responses in children with recurrent brain tumors, providing a basis for advancing to Phase 2/3 trials for pediatric brain tumors. [Read the Full Post]

Selective inhibition of indoleamine and tryptophan 2,3-dioxygenases: Comparative study on kynurenine pathway in cell lines via LC-MS/MS-based targeted metabolomics

131 views | Dec 06 2023

This paper presents a validated LC-MS/MS method to quantify multiple metabolites in the kynurenine pathway, enabling the characterization of cell secretome, insights into disease scenarios, evaluation of enzyme inhibitors, and multivariate analysis, thereby advancing our understanding of cancer immunotherapy and preclinical drug research. [Read the Full Post]

Navoximod modulates local HSV-1 replication to reshape tumor immune microenvironment for enhanced immunotherapy via an injectable hydrogel

177 views | Nov 03 2023

The combination of Navoximod and HSV-1 loaded in an injectable hydrogel (V-Navo@gel) shows promise in enhancing viral replication, reshaping the tumor microenvironment, and improving therapeutic outcomes in hepatocellular carcinoma and rabbit orthotopic liver cancer models. [Read the Full Post]

Multifunctional Polydopamine-Based Nanoparticles for Dual-Mode Imaging Guided Targeted Therapy of Lupus Nephritis

259 views | Nov 16 2022

Mifang Li et al. found that Nec-1/PDA@Pt-Fe3O4 nanocarrier exhibited good biocompatibility. [Read the Full Post]

IDO1 Inhibition Reduces Immune Cell Exclusion Through Inducing Cell Migration While PD-1 Blockage Increases IL-6 and -8 Secretion From T Cells in Head and Neck Cancer

148 views | Aug 19 2022

Meri Sieviläinen et al. revealed the subpopulation of lymphocytes responsible for the increases in specific serum cytokines after ICI treatment. [Read the Full Post]

Expression, purification, and kinetic characterization of the human strep-IDO1

180 views | Aug 19 2022

Dilizhatai Saimi et al. thought that purified human strep-IDO1 using the protocol described in the study could be used for further biochemical and structural analyses, which might facilitate functional research and further drug screening study on IDO1. [Read the Full Post]

The role of RIPK1 mediated cell death in acute on chronic liver failure

646 views | Dec 24 2021

Takayuki Kondo et al. thought that inhibition of RIPK1 was a potential novel therapeutic approach to prevent progression of susceptible patients from no ACLF to ACLF. [Read the Full Post]

Overcoming Chemoimmunotherapy-Induced Immunosuppression by Assemblable and Depot Forming Immune Modulating Nanosuspension

515 views | Sep 24 2021

Seung Mo Jin et al. found that local administration of AIMS increased T cell infiltration in both local and distant tumors and significantly inhibited the metastasis of tumors to the lung. [Read the Full Post]

Pharmacokinetics of S-epacadostat, an indoleamine 2,3-dioxygenase 1 inhibitor, in dog plasma and identification of its metabolites in vivo and in vitro

617 views | Sep 24 2021

Yumu Zhang et al. thought that substituting the nitrogen with sulfur affected the metabolism of the adjacent alkyl side chain. [Read the Full Post]