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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

NF-κB

Lyophilization enhances the stability of Panax notoginseng total saponins-loaded transfersomes without adverse effects on ex vivo/in vivo skin permeation

195 views | Jan 13 2024

Lyophilized Panax notoginseng saponin-loaded transfersomes (PNS-FD-TFSs) exhibit enhanced stability while preserving transdermal absorption, offering a promising advancement in drug delivery systems. [Read the Full Post]

Role of parthenolide in paclitaxel-induced oxidative stress injury and impaired reproductive function in rat testicular tissue

564 views | Dec 28 2023

Parthenolide treatment in rats demonstrated a dose-dependent mitigation of oxidative stress-induced testicular damage caused by paclitaxel, showing promise as a potential therapeutic avenue for addressing testicular toxicity and supporting reproductive function. [Read the Full Post]

Caffeic Acid Phenethyl Ester: A Potential Therapeutic Cancer Agent?

128 views | Dec 20 2023

This narrative review underscores the diverse biological benefits and promising antitumor effects of caffeic acid phenethyl ester (CAPE), derived from propolis, urging further clinical trials to assess its efficacy and safety in treating various forms of human cancer following comprehensive preclinical toxicity assessments. [Read the Full Post]

Scutellarin suppresses the metastasis of triple-negative breast cancer via targeting TNFα/TNFR2-RUNX1-triggered G-CSF expression in endothelial cells

618 views | Nov 13 2023

Scutellarin (SC) inhibits metastasis in triple-negative breast cancer (TNBC) by disrupting the TNFα/TNFR2-initiated RUNX1 activation and subsequent G-CSF production in TNBC-associated endothelial cells (ECs). [Read the Full Post]

Antitumor activity of withaferin-A and propolis in benz (a) pyrene-induced breast cancer

111 views | Nov 07 2023

The study demonstrated that the combination of Withaferin-A and propolis resulted in a decrease in plasma carcinoembryonic antigen (CEA) levels, indicating a potentially beneficial role in Benz(a)pyrene-induced breast cancer. [Read the Full Post]

In silico molecular study of hepatitis B virus X protein as a therapeutic target

179 views | Oct 25 2023

The study identified SC75741, Punicalagin, and Ledipasvir as promising antiviral compounds with strong binding affinity for the HBx protein, suggesting their potential for targeted inhibition of HBx and further research in Hepatitis B treatment. [Read the Full Post]

Dehydrocorydaline Protects Against Sepsis-Induced Myocardial Injury Through Modulating the TRAF6/NF-κB Pathway

149 views | Oct 23 2023

Dehydrocorydaline (Deh) treatment effectively mitigates sepsis-induced myocardial injury by inhibiting the TRAF6/NF-κB pathway, demonstrating its potential as a therapeutic intervention. [Read the Full Post]

Granulocyte-macrophage colony-stimulating factor suppresses induction of type I interferon in infants with severe pneumonia

205 views | Sep 11 2023

The study suggests that the inhibition of type I interferon production in dendritic cells through the GM-CSF-dependent non-canonical NF-κB pathway is a crucial mechanism contributing to the development of severe infantile bronchopneumonia. [Read the Full Post]

Proteasomal pathway inhibition as a potential therapy for NF2-associated meningioma and schwannoma

223 views | Jul 29 2023

This study highlights the potential of proteasome pathway inhibitors, specifically ixazomib and TAK-243, as novel and promising therapies for NF2-associated tumors, demonstrating efficacy in preclinical models and laying the groundwork for future clinical investigations. [Read the Full Post]

UBA1 inhibition contributes radiosensitization of glioblastoma cells via blocking DNA damage repair

276 views | Jul 29 2023

The study demonstrated that the UBA1 inhibitor TAK-243, in combination with ionizing radiation, effectively inhibited GBM cell proliferation, impaired DNA double-strand break repair, and increased apoptosis, providing a potential therapeutic approach to enhance the radiation sensitivity of GBM. [Read the Full Post]