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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

CMV

Enhancing or Quenching of a Mitochondria-Targeted AIEgens-Floxuridine Sensor by the Regulation of pH-Dependent Self-assembly, Efficient Recognition of Hg2+, and Stimulated Response of GSH

350 views | Feb 03 2024

The versatile TPE-FdU fluorescent probe, exhibiting pH-responsive behavior, selective Hg2+ ion detection, and intracellular mitochondrial visualization, represents a promising advancement with diverse applications in cell imaging, environmental monitoring, and biomedical research. [Read the Full Post]

Evaluation of Histone Demethylase Inhibitor ML324 and Acyclovir against Cyprinid herpesvirus 3 Infection

0 views | Jan 03 2024

ML324 demonstrates significant potential as an effective treatment against Cyprinid herpesvirus 3 (CyHV-3) infection in koi fish, outperforming traditional antiviral drugs like acyclovir in inhibiting virus replication both in vitro and in vivo. [Read the Full Post]

Conditional lethality profiling reveals anticancer mechanisms of action and drug-nutrient interactions

89 views | Dec 03 2023

The study screened anticancer and non-oncology compounds in conventional and Human Plasma-Like Medium, revealing a dual mechanism of action for brivudine in folate metabolism and identifying conditional phenotypes for various drugs, offering insights into exploiting conditional lethality for therapeutic candidate discovery. [Read the Full Post]

Assessing the risk of adverse pregnancy outcomes and birth defects reporting in women exposed to ganciclovir or valganciclovir during pregnancy: a pharmacovigilance study

189 views | Apr 22 2023

The analysis of VigiBase found no evidence of increased risk of adverse pregnancy outcomes or birth defects associated with the use of (val)ganciclovir compared to (val)aciclovir during pregnancy, with the exception of four cases of oesophageal and anorectal atresia that require further analysis. [Read the Full Post]

Optimizing ganciclovir and valganciclovir dosing regimens in pediatric patients with cytomegalovirus infection: a spotlight on therapeutic drug monitoring

175 views | Mar 10 2023

Therapeutic drug monitoring (TDM) has the potential to improve the efficacy and safety of ganciclovir/valganciclovir use in pediatrics, but further studies are necessary to establish optimal dosing regimens and evaluate the clinical impact of TDM. [Read the Full Post]

Treatment of Congenital Cytomegalovirus and Ganciclovir Therapeutic Drug Monitoring in Twin Preterm Infants

83 views | Mar 10 2023

The case report highlights the importance of individualized treatment and close monitoring in premature infants with congenital cytomegalovirus infection, and the use of therapeutic drug monitoring to adapt to their evolving physiologic maturation. [Read the Full Post]

Evaluation of cytomegalovirus infection/disease in IgG positive renal transplantation recipients on valaciclovir prophylaxis

134 views | Mar 09 2023

This study found that valacyclovir may be a preferable prophylaxis for CMV infection in renal transplant recipients due to its efficacy and fewer side effects compared to valganciclovir. [Read the Full Post]

Emergence of monkeypox: a worldwide public health crisis

160 views | Feb 23 2023

Monkeypox, a zoonotic virus similar to smallpox that infects humans, has become a global health threat with growing incidence and geographic distribution, and currently lacks a specific therapy but can be treated with vaccines and FDA-approved antiviral medications such as brincidofovir, tecovirimat, and cidofovir. [Read the Full Post]