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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

PGC-1α

Regulation of pericyte metabolic reprogramming restricts the AKI to CKD transition

96 views | Nov 04 2023

Metabolic reprogramming, characterized by decreased fatty acid oxidation and increased glycolysis, plays a critical role in pericyte-myofibroblast transition and targeting pericyte metabolism may prevent the progression of acute kidney injury to chronic kidney disease. [Read the Full Post]

SIRT3 ameliorates polycystic ovary syndrome through FOXO1/PGC-1α signaling pathway

99 views | Aug 09 2023

The study demonstrates that SIRT3 regulates the FOXO1/PGC-1α signaling pathway, mitigating mitochondrial dysfunction and improving polycystic ovary syndrome (PCOS). [Read the Full Post]

Perinatal Stressors as a Factor in Impairments to Nervous System Development and Functions: Review of In Vivo Models

439 views | Apr 21 2023

This review evaluates different models of perinatal pathology and their relationship with psychoemotional stressors in understanding the impact of stress on the developing brain and behavior. [Read the Full Post]

Adequacy of energy and macronutrients intake in differently active slovenian adolescents

545 views | Apr 21 2023

The study found that a significant proportion of Slovenian adolescents are not meeting national recommendations for energy and macronutrient intake, and there were differences in energy/macronutrient intake between boys of different physical activity levels, highlighting the need for interventions to encourage healthy eating and physical activity behaviors. [Read the Full Post]