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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

MAO

Exploration of a new class of monoamine oxidase B inhibitors by assembling benzyloxy pharmacophore on halogenated chalcones

119 views | Feb 14 2024

BB2 and BB4, derivatives of benzyloxy-derived halogenated chalcones, exhibit potent, selective, and reversible inhibition of MAO-B, marking them as promising drug candidates for treating neurodegenerative disorders like Parkinson's disease. [Read the Full Post]

Active natural compounds perturb the melanoma risk-gene network

376 views | Jan 07 2024

The study ingeniously employs network modeling of melanoma-associated genes, revealing crucial pathways and potential therapeutic targets while showcasing the predictive potential of this model in evaluating the efficacy of anti-melanoma phytochemicals. [Read the Full Post]

Safety comparisons among monoamine oxidase inhibitors against Parkinson's disease using FDA adverse event reporting system

109 views | Dec 23 2023

Understanding the distinct adverse event profiles among MAO-B inhibitors like selegiline, rasagiline, and safinamide illuminates nuanced differences in their safety profiles, aiding clinicians in personalized Parkinson's disease management. [Read the Full Post]

Dipotassium Glycyrrhizininate Improves Skin Wound Healing by Modulating Inflammatory Process

277 views | Mar 22 2023

The study evaluated the anti-inflammatory effect of topical Dipotassium Glycyrrhizinate (DPG) on the healing of cutaneous wounds by secondary intention in an in vivo experimental model and found that DPG promotes skin wound healing through modulation of distinct mechanisms and signaling pathways, including anti-inflammatory ones. [Read the Full Post]

Harmine Induces Adipocyte Thermogenesis through RAC1-MEK-ERK-CHD4 Axis

1548 views | Sep 22 2017

Nie T et al. reveal a new application of harmine in combating obesity via this off-target effect in adipocytes. [Read the Full Post]

Endothelial Cell Apoptosis Induces TGF-b Signaling-Dependent Host Endothelial–Mesenchymal Transition to Promote Transplant Arteriosclerosis

3222 views | Mar 05 2017

Li J et al. suggested that allograft EC apoptosis induced recipient endothelial-mesenchymal (smooth muscle) transition via TGF-β signaling, resulting in recipient EC-derived SMC accumulation as a major mechanism of vascular remodeling during TA. [Read the Full Post]