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glucocerebrosidase

Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase

115 views | Apr 18 2023

High-throughput screening has identified ML198 and ML266 as chemical series that can facilitate translocation of mutant GCase to the lysosome without inhibiting the enzyme's activity, providing a potential starting point for the development of small molecule treatments for Gaucher disease. [Read the Full Post]