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Archives
FXR
Cholic Acid-Derived Gemini Amphiphile Can Eradicate Interkingdom Polymicrobial Biofilms and Wound Infections
125 views | Feb 16 2024
The bile acid-derived gemini amphiphile G21 exhibits broad-spectrum antimicrobial efficacy, disrupting microbial cell membranes and eradicating polymicrobial biofilms while curbing drug resistance, indicating its potential as a versatile agent for combatting chronic infections. [Read the Full Post]
Physicochemical investigation and molecular docking analysis of Maha yogaraj Guggulu tablet and virtual screening of its major bioactive compound
101 views | Jan 17 2024
A computational study identified Guggulsterone isomers as potential high-affinity inhibitors of the Farnesoid X Receptor with promising cholesterol-lowering capabilities, while indicating concerns regarding their CYP3A4 inhibition and hepatotoxicity. [Read the Full Post]
Suppression of lung oxidative stress, inflammation and fibrosis following nitrogen mustard exposure by the selective farnesoid X receptor agonist obeticholic acid
126 views | Jun 21 2023
Activation of the farnesoid X receptor (FXR) through treatment with obeticholic acid attenuates nitrogen mustard-induced lung injury, oxidative stress, inflammation, and fibrosis, suggesting FXR activation as a potential therapeutic strategy for limiting cytotoxic vesicant toxicity. [Read the Full Post]
Administration of an LXR agonist promotes atherosclerotic lesion remodelling in murine inflammatory arthritis
175 views | May 20 2023
The study shows that the LXR agonist T0901317 improves cholesterol efflux and atherosclerotic lesion regression in murine arthritis, potentially offering therapeutic benefits for patients with rheumatoid arthritis and atherosclerotic cardiovascular disease. [Read the Full Post]
DEHP Decreases Steroidogenesis through the cAMP and ERK1/2 Signaling Pathways in FSH-Stimulated Human Granulosa Cells
223 views | Mar 23 2023
DEHP inhibits the cAMP and ERK1/2 signaling pathways, leading to the inhibition of steroidogenesis in FSH-stimulated hCGC. [Read the Full Post]
GW4064 Alters Gut Microbiota Composition and Counteracts Autism-Associated Behaviors in BTBR T+tf/J Mice
224 views | Sep 21 2022
Jiayin Liu et al. suggested that GW4064 supplementation might prove a potential strategy for improving ASD symptoms. [Read the Full Post]
The Effects of PI3K/Akt/mTOR Signaling Pathway Inhibitors on the Expression of Immune Checkpoint Ligands in Acute Myeloid Leukemia Cell Line
284 views | May 04 2022
Saeid Taghiloo et al. found that combinational treatment approaches to block these pathways might be a promising and novel therapeutic strategy for AML patients via interfering in immune escape mechanisms. [Read the Full Post]
Inhibition of DDX3 and COX-2 by forskolin and evaluation of anti-proliferative, pro-apoptotic effects on cervical cancer cells: molecular modelling and in vitro approaches
207 views | May 03 2022
Doneti Ravinder et al. found that the FSK engaged the active sites of both the targets by interacting with key residues. [Read the Full Post]
Farnesoid X receptor (FXR) inhibits coagulation process via inducing hepatic antithrombin III expression in mice
375 views | Oct 30 2021
Zhi-Lin Luan et al. found that new role of FXR in hemostatic homeostasis and indicates that FXR might act as a potential therapeutic target for diseases related to hypercoagulation. [Read the Full Post]
The Tumor Microenvironment in Follicular Lymphoma: Its Pro-Malignancy Role with Therapeutic Potential
659 views | Jun 10 2021
Takashi Watanabe found that Tfh, and TFR cells could reinforce the effects of the cytotoxic T cells. [Read the Full Post]
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