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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Antibiotics

A Rare Case of Neurosyphilis with Calvaria Osteitis Presenting in Pregnancy

95 views | Feb 14 2024

Syphilitic osteitis and neuro, otic, or ocular syphilis during pregnancy, though rare and challenging to manage due to limited data, underscore the critical need for thorough screening, prompt recognition, and tailored treatment protocols to ensure optimal outcomes for both mother and fetus. [Read the Full Post]

Repurposing Polyether Ionophores as a New-Class of Anti-SARS-Cov-2 Agents as Adjunct Therapy

118 views | Jan 11 2024

The repurposing of veterinary polyether ionophores, supported by in vitro and in vivo studies, demonstrates promising potential in inhibiting SARS-CoV-2 through multi-target interactions, synergized by Zn2+ supplementation, highlighting a compelling avenue for novel therapeutic strategies against COVID-19. [Read the Full Post]

Impact of antibiotic pharmacokinetics in urine on recurrent bacteriuria following treatment of complicated urinary tract infections

114 views | Dec 21 2023

The prolonged urinary clearance and dwell time of ertapenem, compared to tebipenem, in a study evaluating complicated urinary tract infections, introduced a temporal difference in bacterial repopulation, potentially confounding the assessment of efficacy and contributing to the ongoing controversy regarding the clinical relevance of bacteriuria post-antibiotic treatment. [Read the Full Post]

Solithromycin inhibits IL-13-induced goblet cell hyperplasia and MUC5AC, CLCA1, and ANO1 in human bronchial epithelial cells

114 views | Oct 10 2023

Solithromycin was found to attenuate IL-13-induced goblet cell hyperplasia and MUC5AC production by inhibiting the mRNA and protein expression of CLCA1 and ANO1, independent of STAT6 and ERK phosphorylation. [Read the Full Post]

Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer

166 views | Jun 07 2023

This study demonstrates that aberrant RNA m5C modification via the NSUN2-YBX1-QSOX1 axis plays a critical role in mediating intrinsic resistance to gefitinib in EGFR-mutant NSCLC. [Read the Full Post]

Kv1.3 blockade by ShK186 modulates CD4+ effector memory T-cell activity of patients with Granulomatosis with polyangiitis

280 views | May 19 2023

The study suggests that Kv1.3 blockade using ShK-186 may be a potential treatment strategy for GPA by modulating the activity of CD4+TEM cells and reducing the production of pro-inflammatory cytokines, with less harmful side effects than current immunosuppressive regimens. [Read the Full Post]

A large-scale functional analysis of genes expressed differentially in insulin secreting MIN6 sublines with high versus mildly reduced glucose-responsiveness

227 views | May 01 2023

This study identified 18 genes that altered glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells, and confirmed Sox11 as a negative regulator of insulin secretion and its role in glucose metabolism. [Read the Full Post]

The usefulness of pretreatment controlling nutritional status score for predicting recurrence in patients with esophageal squamous cell carcinoma undergoing neoadjuvant immunochemotherapy: A real-world study

91 views | Apr 28 2023

The study suggests that the controlling nutritional status (CONUT) score is a reliable prognostic indicator in esophageal squamous cell carcinoma (ESCC) patients undergoing neoadjuvant immunochemotherapy (nICT), with a low pretreatment CONUT score associated with a better response to treatment and a lower recurrence rate. [Read the Full Post]

Characterization of the Interactions between Minocycline Hydrochloride and Trypsin with Spectroscopic and Molecular Docking Technology

223 views | Apr 24 2023

This study investigated the interaction between minocycline hydrochloride and trypsin using various spectroscopic and molecular docking techniques and demonstrated its impact on the secondary structure of trypsin. [Read the Full Post]

Multifunctional porous poly (L-lactic acid) nanofiber membranes with enhanced anti-inflammation, angiogenesis and antibacterial properties for diabetic wound healing

257 views | Apr 22 2023

The study developed porous PLA/SCS/PDA-GS nanofiber membranes with enhanced antibacterial, anti-inflammatory, and angiogenic properties, demonstrating promising potential in diabetic wound healing processes. [Read the Full Post]